Tchem PNPLA2 Patatin-like phospholipase domain-containing protein 2

Protein Summary

Description

Catalyzes the initial step in triglyceride hydrolysis in adipocyte and non-adipocyte lipid droplets (PubMed:15550674). Also has acylglycerol transacylase activity. May act coordinately with LIPE/HLS within the lipolytic cascade. Regulates adiposome size and may be involved in the degradation of adiposomes (PubMed:16239926). May play an important role in energy homeostasis. May play a role in the response of the organism to starvation, enhancing hydrolysis of triglycerides and providing free fatty acids to other tissues to be oxidized in situations of energy depletion. This gene encodes an enzyme which catalyzes the first step in the hydrolysis of triglycerides in adipose tissue. Mutations in this gene are associated with neutral lipid storage disease with myopathy. [provided by RefSeq, Jul 2010]

Uniprot Accession IDs

• Q96AD5
• O60643
• Q5EFF5
• Q6XYE5
• Q96ET6
• Q9NQ61
• Q9NQ62

Gene Name

• PNPLA2

Ensembl ID

• ENST00000336615
• ENSP00000337701
• ENSG00000177666

Symbol

• ATGL
• ATGL
• TTS2
• PEDF-R
• FP17548
• TTS-2.2
• iPLA2zeta
• 1110001C14Rik

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.9
metabolite	0.88
transcription factor perturbation	0.88
transcription factor	0.69
disease	0.68

Protein Classes

PANTHER Classes

Protein / Transferase / Acyltransferase / Patatin-like Phospholipase Domain-containing Protein 2

Protein / Hydrolase / Lipase / Phospholipase / Patatin-like Phospholipase Domain-containing Protein 2

DTO Classes

Protein / Enzyme / Hydrolase / Lipase / Phospholipase / Patatin-like Phospholipase Domain-containing Protein 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 816.51   (req: < 5)

Gene RIFs: 112   (req: <= 3)

Antibodies: 486   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 816.51   (req: >= 5)

Gene RIFs: 112   (req: > 3)

Antibodies: 486   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0