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Tbio
KIFC2
Kinesin-like protein KIFC2

Protein Summary
Description
May play a role in microtubule-dependent retrograde axonal transport. May function as the motor for the transport of multivesicular body (MVB)-like organelles in dendrites (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000301332
  • ENSP00000301332
  • ENSG00000167702
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.98
cell type or tissue
0.8
virus perturbation
0.68
protein domain
0.58
cell line
0.55


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.08   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 72   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.08   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 72   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
2
2
2
96.4
alcohol abuse
1
1
1
50.4
serum alanine aminotransferase measurement
1
1
1
50.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
2
96.4
alcohol abuse
1
50.4
serum alanine aminotransferase measurement
1
50.4
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
kinesin family member C2
VGNC:857
464467
Macaque
kinesin family member C2
702650
Mouse
MGI:109187
16581
Rat
RGD:735021
300053
Dog
kinesin family member C2
VGNC:42415
475128
Species
Name
OMA
EggNOG
Inparanoid
Chimp
kinesin family member C2
Macaque
kinesin family member C2
Mouse
Rat
Dog
kinesin family member C2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q96AC6-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (8)
COPI-dependent Golgi-to-ER retrograde traffic (R-HSA-6811434)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
COPI-dependent Golgi-to-ER retrograde traffic
Reactome
Factors involved in megakaryocyte development and platelet production
Reactome
Golgi-to-ER retrograde transport
Reactome
Hemostasis
Reactome
Intra-Golgi and retrograde Golgi-to-ER traffic
Name
Explore in Pharos
Explore in Source
COPI-dependent Golgi-to-ER retrograde traffic
Factors involved in megakaryocyte development and platelet production
Golgi-to-ER retrograde transport
Hemostasis
Intra-Golgi and retrograde Golgi-to-ER traffic
Gene Ontology Terms (8)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (129)
1 – 10 of 129
KIF11
Tchem
Novelty: 0.00170673
Score: 0.973
Data Source: STRINGDB
KLC2
Tbio
Novelty: 0.06284367
Score: 0.948
Data Source: STRINGDB
KIF6
Tbio
Novelty: 0.02486302
Score: 0.947
Data Source: STRINGDB
CENPE
Tchem
Novelty: 0.00458125
Score: 0.946
Data Source: STRINGDB
KIF18A
Tbio
Novelty: 0.02071108
Score: 0.943
Data Source: STRINGDB
RAB1A
Tbio
Family: Enzyme
Novelty: 0.00307527
Score: 0.942
Data Source: STRINGDB
KIF19
Tbio
Novelty: 0.16131415
Score: 0.941
Data Source: STRINGDB
KIF18B
Tbio
Novelty: 0.06496349
Score: 0.94
Data Source: STRINGDB
KIF22
Tbio
Novelty: 0.0109594
Score: 0.939
Data Source: STRINGDB
KIFAP3
Tbio
Novelty: 0.01902437
Score: 0.939
Data Source: STRINGDB
Publication Statistics
PubMed Score  8.08

PubMed score by year
PubTator Score  0.87

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer