Tbio FERMT2 Fermitin family homolog 2

Protein Summary

Description

Scaffolding protein that enhances integrin activation mediated by TLN1 and/or TLN2, but activates integrins only weakly by itself. Binds to membranes enriched in phosphoinositides. Enhances integrin-mediated cell adhesion onto the extracellular matrix and cell spreading; this requires both its ability to interact with integrins and with phospholipid membranes. Required for the assembly of focal adhesions. Participates in the connection between extracellular matrix adhesion sites and the actin cytoskeleton and also in the orchestration of actin assembly and cell shape modulation. Recruits FBLIM1 to focal adhesions. Plays a role in the TGFB1 and integrin signaling pathways. Stabilizes active CTNNB1 and plays a role in the regulation of transcription mediated by CTNNB1 and TCF7L2/TCF4 and in Wnt signaling.

Uniprot Accession IDs

• Q96AC1
• B5TJY2
• Q14840
• Q86TY7

Gene Name

• FERMT2

Ensembl ID

• ENST00000341590
• ENSP00000340391
• ENSG00000073712
• ENST00000343279
• ENSP00000342858
• ENST00000395631
• ENSP00000378993
• ENST00000399304
• ENSP00000382243
• ENST00000553373
• ENSP00000451084

Symbol

• KIND2
• MIG2
• PLEKHC1
• MIG2
• KIND2
• mig-2
• UNC112
• PLEKHC1
• UNC112B

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.85
disease perturbation	0.83
ligand (protein) perturbation	0.83
transcription factor perturbation	0.8
transcription factor binding site profile	0.77

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 165.14   (req: < 5)

Gene RIFs: 68   (req: <= 3)

Antibodies: 273   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 165.14   (req: >= 5)

Gene RIFs: 68   (req: > 3)

Antibodies: 273   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0