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Tbio
FERMT2
Fermitin family homolog 2

Protein Summary
Description
Scaffolding protein that enhances integrin activation mediated by TLN1 and/or TLN2, but activates integrins only weakly by itself. Binds to membranes enriched in phosphoinositides. Enhances integrin-mediated cell adhesion onto the extracellular matrix and cell spreading; this requires both its ability to interact with integrins and with phospholipid membranes. Required for the assembly of focal adhesions. Participates in the connection between extracellular matrix adhesion sites and the actin cytoskeleton and also in the orchestration of actin assembly and cell shape modulation. Recruits FBLIM1 to focal adhesions. Plays a role in the TGFB1 and integrin signaling pathways. Stabilizes active CTNNB1 and plays a role in the regulation of transcription mediated by CTNNB1 and TCF7L2/TCF4 and in Wnt signaling.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000341590
  • ENSP00000340391
  • ENSG00000073712
  • ENST00000343279
  • ENSP00000342858
  • ENST00000395631
  • ENSP00000378993
  • ENST00000399304
  • ENSP00000382243
  • ENST00000553373
  • ENSP00000451084

Symbol
  • KIND2
  • MIG2
  • PLEKHC1
  • MIG2
  • KIND2
  • mig-2
  • UNC112
  • PLEKHC1
  • UNC112B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
disease perturbation
0.83
ligand (protein) perturbation
0.83
transcription factor perturbation
0.8
transcription factor binding site profile
0.77


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 134.28   (req: < 5)
Gene RIFs: 48   (req: <= 3)
Antibodies: 273   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 134.28   (req: >= 5)
Gene RIFs: 48   (req: > 3)
Antibodies: 273   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intraocular pressure measurement
4
2
4
90.1
prostate carcinoma
3
2
0
1.1
83.7
primary angle closure glaucoma
1
1
0
1.1
66.3
1
1
0
1.1
41.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intraocular pressure measurement
4
90.1
prostate carcinoma
0
1.1
83.7
primary angle closure glaucoma
0
1.1
66.3
0
1.1
41.1
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
fermitin family member 2
VGNC:3424
452910
Macaque
fermitin family member 2 [Source:HGNC Symbol;Acc:HGNC:15767]
Mouse
MGI:2385001
218952
Rat
RGD:1311799
289992
Dog
fermitin family member 2
VGNC:40823
490693
Species
Name
OMA
EggNOG
Inparanoid
Chimp
fermitin family member 2
Macaque
fermitin family member 2 [Source:HGNC Symbol;Acc:HGNC:15767]
Mouse
Rat
Dog
fermitin family member 2
Protein Data Bank (4)
1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (3)
Cell junction organization (R-HSA-446728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell junction organization
Reactome
Cell-Cell communication
Reactome
Cell-extracellular matrix interactions
Name
Explore in Pharos
Explore in Source
Cell junction organization
Cell-Cell communication
Cell-extracellular matrix interactions
Protein-Protein Interactions (111)
1 – 10 of 111
AP3M1
Tbio
Novelty: 0.5036622
p_int: 0.99999992
p_ni: 7.9e-8
p_wrong: 1e-9
Score: 0.177
Data Source: BioPlex,STRINGDB
WDR20
Tbio
Novelty: 0.03031804
p_int: 0.999999919
p_ni: 8.1e-8
Score: 0.189
Data Source: BioPlex,STRINGDB
FERMT1
Tbio
Novelty: 0.0088821
p_int: 0.999999833
p_ni: 1.64e-7
p_wrong: 2e-9
Score: 0.834
Data Source: BioPlex,STRINGDB
F9
Tchem
Family: Enzyme
Novelty: 0.00032127
p_int: 0.999971077
p_ni: 0.000028923
Data Source: BioPlex
GREM2
Tbio
Novelty: 0.01839564
p_int: 0.999865355
p_ni: 0.000134621
p_wrong: 2.3e-8
Data Source: BioPlex
G0S2
Tbio
Novelty: 0.02273959
p_int: 0.993077668
p_ni: 0.00670779
p_wrong: 0.000214542
Data Source: BioPlex
BIRC6
Tbio
Novelty: 0.01187953
p_int: 0.956858391
p_ni: 0.043141609
Score: 0.165
Data Source: BioPlex,STRINGDB
FERMT3
Tbio
Novelty: 0.01172918
p_int: 0.956535122
p_ni: 0.042216949
p_wrong: 0.001247929
Score: 0.864
Data Source: BioPlex,STRINGDB
RIPPLY2
Tdark
Novelty: 0.16163153
p_int: 0.94639277
p_ni: 0.052851949
p_wrong: 0.000755281
Score: 0.188
Data Source: BioPlex,STRINGDB
FBLIM1
Tbio
Novelty: 0.0332985
Score: 0.996
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  134.28

PubMed score by year
PubTator Score  83.95

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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