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Tbio
RFT1
Protein RFT1 homolog

Protein Summary
Description
May be involved in N-linked oligosaccharide assembly. May participate in the translocation of oligosaccharide from the cytoplasmic side to the lumenal side of the endoplasmic reticulum membrane. This gene encodes an enzyme which catalyzes the translocation of the Man(5)GlcNAc (2)-PP-Dol intermediate from the cytoplasmic to the luminal side of the endoplasmic reticulum membrane in the pathway for the N-glycosylation of proteins. Mutations in this gene are associated with congenital disorder of glycosylation type In.[provided by RefSeq, Dec 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000296292
  • ENSP00000296292
  • ENSG00000163933

Symbol
  • CDG1N
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.9
kinase perturbation
0.76
microRNA
0.75
transcription factor binding site profile
0.69
tissue sample
0.61


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.07   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 88   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.07   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 88   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
2
2
1
59.8
BMI-adjusted hip circumference
1
1
2
49.9
anthropometric measurement
1
1
0
1.1
46.6
high density lipoprotein cholesterol measurement
1
1
1
22.2
1
2
0
1.1
17
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
1
59.8
BMI-adjusted hip circumference
2
49.9
anthropometric measurement
0
1.1
46.6
high density lipoprotein cholesterol measurement
1
22.2
0
1.1
17
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RFT1 homolog
460441
Macaque
RFT1 homolog
694586
Mouse
MGI:3607791
328370
Rat
RGD:1562654
290552
Dog
RFT1 homolog
476589
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RFT1 homolog
Macaque
RFT1 homolog
Mouse
Rat
Dog
RFT1 homolog
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q96AA3-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (8)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Reactome
Defective RFT1 causes RFT1-CDG (CDG-1n)
Reactome
Disease
Reactome
Diseases associated with N-glycosylation of proteins
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Defective RFT1 causes RFT1-CDG (CDG-1n)
Disease
Diseases associated with N-glycosylation of proteins
Gene Ontology Terms (5)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (29)
1 – 10 of 29
LYPD3
Tbio
Novelty: 0.03248533
p_int: 0.835838867
p_ni: 0.164161133
Score: 0.173
Data Source: BioPlex,STRINGDB
ADGRG5
Tdark
Family: GPCR
Novelty: 0.26575982
p_int: 0.777794413
p_ni: 0.222205587
Score: 0.177
Data Source: BioPlex,STRINGDB
ALG11
Tbio
Family: Enzyme
Novelty: 0.00872486
Score: 0.965
Data Source: STRINGDB
PMM2
Tchem
Family: Enzyme
Novelty: 0.01177513
Score: 0.796
Data Source: STRINGDB
ALG2
Tbio
Family: Enzyme
Novelty: 0.03804805
Score: 0.772
Data Source: STRINGDB
ZNF668
Tdark
Family: TF
Novelty: 0.4005044
Score: 0.769
Data Source: STRINGDB
TOR3A
Tbio
Novelty: 0.11588309
Score: 0.714
Data Source: STRINGDB
ALG5
Tbio
Family: Enzyme
Novelty: 0.04358658
Score: 0.626
Data Source: STRINGDB
DOLK
Tbio
Family: Enzyme
Novelty: 0.00664639
Score: 0.614
Data Source: STRINGDB
ALG1
Tbio
Family: Enzyme
Novelty: 0.012911
Score: 0.612
Data Source: STRINGDB
Publication Statistics
PubMed Score  0.07

PubMed score by year
PubTator Score  22.55

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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