RFT1
Protein RFT1 homolog
Protein Summary
May be involved in N-linked oligosaccharide assembly. May participate in the translocation of oligosaccharide from the cytoplasmic side to the lumenal side of the endoplasmic reticulum membrane. This gene encodes an enzyme which catalyzes the translocation of the Man(5)GlcNAc (2)-PP-Dol intermediate from the cytoplasmic to the luminal side of the endoplasmic reticulum membrane in the pathway for the N-glycosylation of proteins. Mutations in this gene are associated with congenital disorder of glycosylation type In.[provided by RefSeq, Dec 2008]
- ENST00000296292
- ENSP00000296292
- ENSG00000163933
- CDG1N
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
histone modification site profile | 0.9 | ||
kinase perturbation | 0.76 | ||
microRNA | 0.75 | ||
transcription factor binding site profile | 0.69 | ||
tissue sample | 0.61 | ||
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 0.07 (req: < 5)
Gene RIFs: 5 (req: <= 3)
Antibodies: 88 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 0.07 (req: >= 5)
Gene RIFs: 5 (req: > 3)
Antibodies: 88 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 3
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
GWAS Traits (7)
Items per page:
1 – 5 of 7
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
3 | 2 | 2 | 1 | 59.8 | |||||
BMI-adjusted hip circumference | 1 | 1 | 2 | 49.9 | |||||
anthropometric measurement | 1 | 1 | 0 | 1.1 | 46.6 | ||||
high density lipoprotein cholesterol measurement | 1 | 1 | 1 | 22.2 | |||||
1 | 2 | 0 | 1.1 | 17 | |||||
Items per page:
1 – 5 of 7
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
2 | 1 | 59.8 | |||||
BMI-adjusted hip circumference | 2 | 49.9 | |||||
anthropometric measurement | 0 | 1.1 | 46.6 | ||||
high density lipoprotein cholesterol measurement | 1 | 22.2 | |||||
0 | 1.1 | 17 | |||||
Orthologs (15)
1 – 5 of 15
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | RFT1 homolog | 460441 | ||||||
Macaque | RFT1 homolog | 694586 | ||||||
Mouse | MGI:3607791 | 328370 | ||||||
Rat | RGD:1562654 | 290552 | ||||||
Dog | RFT1 homolog | 476589 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | RFT1 homolog | |||||
Macaque | RFT1 homolog | |||||
Mouse | ||||||
Rat | ||||||
Dog | RFT1 homolog | |||||
Protein Structure (0 Structures, 1 AlphaFold Model)
Pathways (8)
Reactome (8)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 8
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Asparagine N-linked glycosylation | ||||
Reactome | Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein | ||||
Reactome | Defective RFT1 causes RFT1-CDG (CDG-1n) | ||||
Reactome | Disease | ||||
Reactome | Diseases associated with N-glycosylation of proteins | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Asparagine N-linked glycosylation | ||||
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein | ||||
Defective RFT1 causes RFT1-CDG (CDG-1n) | ||||
Disease | ||||
Diseases associated with N-glycosylation of proteins | ||||
Gene Ontology Terms (5)
Functions (1)
Components (2)
Processes (2)
Items per page:
10
1 – 1 of 1
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Electronic Annotation (IEA) | InterPro | |||
Protein-Protein Interactions (29)
1 – 10 of 29
LYPD3
Novelty: 0.03248533
p_int: 0.835838867
p_ni: 0.164161133
Score: 0.173
Data Source: BioPlex,STRINGDB
ADGRG5
Family: GPCR
Novelty: 0.26575982
p_int: 0.777794413
p_ni: 0.222205587
Score: 0.177
Data Source: BioPlex,STRINGDB
ALG11
Family: Enzyme
Novelty: 0.00872486
Score: 0.965
Data Source: STRINGDB
PMM2
Family: Enzyme
Novelty: 0.01177513
Score: 0.796
Data Source: STRINGDB
ALG2
Family: Enzyme
Novelty: 0.03804805
Score: 0.772
Data Source: STRINGDB
ZNF668
Family: TF
Novelty: 0.4005044
Score: 0.769
Data Source: STRINGDB
TOR3A
Novelty: 0.11588309
Score: 0.714
Data Source: STRINGDB
ALG5
Family: Enzyme
Novelty: 0.04358658
Score: 0.626
Data Source: STRINGDB
DOLK
Family: Enzyme
Novelty: 0.00664639
Score: 0.614
Data Source: STRINGDB
ALG1
Family: Enzyme
Novelty: 0.012911
Score: 0.612
Data Source: STRINGDB
Publication Statistics
PubMed Score 0.07
PubMed score by year
PubTator Score 22.55
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
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