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Tdark
PTH2
Tuberoinfundibular peptide of 39 residues

Protein Classes
Protein Summary
Description
Plays a role as a potent and selective agonist of PTH2R resulting in adenyl cyclase activation and intracellular calcium levels elevation. Induces protein kinase C beta activation, recruitment of beta-arrestin and PTH2R internalization. May inhibit cell proliferation via its action on PTH2R activation. Neuropeptide which may also have a role in spermatogenesis. May activate nociceptors and nociceptive circuits. This gene encodes the precursor of a peptide hormone that shares sequence similarity with the parathyroid hormone. This gene is expressed in various regions of the brain where it plays a role in the release of pituitary hormones, anxiety and nociception. The encoded precursor protein is proteolytically processed to generate the biologically active neuropeptide. [provided by RefSeq, Jul 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000270631
  • ENSP00000270631
  • ENSG00000142538

Symbol
  • TIP39
  • TIPF39
  • TIP39
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell line
0.46
metabolite
0.45
transcription factor
0.45
pathway
0.44
phenotype
0.42


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 45.22   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 48   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 45.22   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 48   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (7)
Class B/2 (Secretin family receptors) (R-HSA-373080)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class B/2 (Secretin family receptors)
Reactome
G alpha (s) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Signal Transduction
Name
Explore in Pharos
Explore in Source
Class B/2 (Secretin family receptors)
G alpha (s) signalling events
GPCR downstream signalling
GPCR ligand binding
Signal Transduction
Gene Ontology Terms (3)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
Reactome
Protein-Protein Interactions (134)
1 – 10 of 134
AMD1
Tchem
Family: Enzyme
Novelty: 0.00231813
p_int: 0.901846248
p_ni: 0.098153752
Score: 0.309
Data Source: BioPlex,STRINGDB
PTH2R
Tchem
Family: GPCR
Novelty: 0.03397859
Score: 0.992
Data Source: Reactome,STRINGDB
PTH
Tbio
Novelty: 0.00003263
Score: 0.981
Data Source: STRINGDB
PTH1R
Tclin
Family: GPCR
Novelty: 0.00413989
Score: 0.974
Data Source: Reactome,STRINGDB
PTHLH
Tbio
Novelty: 0.00050137
Score: 0.958
Data Source: STRINGDB
CRH
Tbio
Novelty: 0.000147
Score: 0.945
Data Source: STRINGDB
AVP
Tbio
Novelty: 0.00016475
Score: 0.94
Data Source: STRINGDB
SCTR
Tclin
Family: GPCR
Novelty: 0.01163942
Score: 0.939
Data Source: STRINGDB
CALCA
Tbio
Novelty: 0.00010496
Score: 0.932
Data Source: STRINGDB
CALCA
Tclin
Novelty: 0.00010496
Score: 0.932
Data Source: STRINGDB
Publication Statistics
PubMed Score  45.22

PubMed score by year
PubTator Score  41.37

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer