PTH2
Tuberoinfundibular peptide of 39 residues
Protein Summary
Plays a role as a potent and selective agonist of PTH2R resulting in adenyl cyclase activation and intracellular calcium levels elevation. Induces protein kinase C beta activation, recruitment of beta-arrestin and PTH2R internalization. May inhibit cell proliferation via its action on PTH2R activation. Neuropeptide which may also have a role in spermatogenesis. May activate nociceptors and nociceptive circuits. This gene encodes the precursor of a peptide hormone that shares sequence similarity with the parathyroid hormone. This gene is expressed in various regions of the brain where it plays a role in the release of pituitary hormones, anxiety and nociception. The encoded precursor protein is proteolytically processed to generate the biologically active neuropeptide. [provided by RefSeq, Jul 2015]
- ENST00000270631
- ENSP00000270631
- ENSG00000142538
- TIP39
- TIPF39
- TIP39
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
cell line | 0.46 | ||
metabolite | 0.45 | ||
transcription factor | 0.45 | ||
pathway | 0.44 | ||
phenotype | 0.42 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 47.6 (req: < 5)
Gene RIFs: 3 (req: <= 3)
Antibodies: 48 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 47.6 (req: >= 5)
Gene RIFs: 3 (req: > 3)
Antibodies: 48 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 2
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0