Tbio EXOC4 Exocyst complex component 4

Protein Summary

Description

Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and functions of exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. The complex is also essential for the biogenesis of epithelial cell surface polarity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q96A65
• E9PED2
• Q541U8
• Q9C0G4
• Q9H9K0
• Q9P102

Gene Name

• EXOC4

Ensembl ID

• ENST00000253861
• ENSP00000253861
• ENSG00000131558
• ENST00000393161
• ENSP00000376868

Symbol

• KIAA1699
• SEC8
• SEC8L1
• SEC8
• Sec8p
• SEC8L1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	1
co-expressed gene	0.99
virus perturbation	0.99
kinase perturbation	0.88
transcription factor perturbation	0.88

Protein Classes

PANTHER Classes

Protein / Membrane Traffic Protein / Exocyst Complex Component 4

DTO Classes

Protein / Transporter / Exocyst Complex Component 4

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 67.56   (req: < 5)

Gene RIFs: 12   (req: <= 3)

Antibodies: 155   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 67.56   (req: >= 5)

Gene RIFs: 12   (req: > 3)

Antibodies: 155   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0