Tbio EXOC4 Exocyst complex component 4

Protein Classes

PANTHER Classes

Protein / Membrane Traffic Protein / Exocyst Complex Component 4

DTO Classes

Protein / Transporter / Exocyst Complex Component 4

Protein Summary

Description

Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and functions of exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. The complex is also essential for the biogenesis of epithelial cell surface polarity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q96A65
• E9PED2
• Q541U8
• Q9C0G4
• Q9H9K0
• Q9P102

Gene Name

• EXOC4

Ensembl ID

• ENST00000253861
• ENSP00000253861
• ENSG00000131558
• ENST00000393161
• ENSP00000376868

Symbol

• KIAA1699
• SEC8
• SEC8L1
• SEC8
• Sec8p
• SEC8L1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	1
co-expressed gene	0.99
virus perturbation	0.99
kinase perturbation	0.88
transcription factor perturbation	0.88

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.19   (req: < 5)

Gene RIFs: 12   (req: <= 3)

Antibodies: 155   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.19   (req: >= 5)

Gene RIFs: 12   (req: > 3)

Antibodies: 155   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

GWAS Traits (16)

• Explore on Target Illumination GWAS Analytics (TIGA)

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GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mathematical ability	EFO_0004875	4	9	10		99.3
self reported educational attainment	EFO_0004784	6	8	6	4.1	99.2
cognitive function measurement	EFO_0008354	3	5	6		98.4
intelligence	EFO_0004337	8	26	15	6	97.6
smoking status measurement	EFO_0006527	2	1	2		91.5

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

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1 – 5 of 16

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mathematical ability	EFO_0004875	10		99.3
self reported educational attainment	EFO_0004784	6	4.1	99.2
cognitive function measurement	EFO_0008354	6		98.4
intelligence	EFO_0004337	15	6	97.6
smoking status measurement	EFO_0006527	2		91.5

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Orthologs (12)

1 – 5 of 12

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	exocyst complex component 4	VGNC:4342	463740
Mouse	exocyst complex component 4	MGI:1096376	20336
Rat	exocyst complex component 4	RGD:621791	116654
Dog	exocyst complex component 4	VGNC:40514	482250
Horse	exocyst complex component 4	VGNC:17723	100065209

Species	Name	OMA	EggNOG	Inparanoid
Chimp	exocyst complex component 4
Mouse	exocyst complex component 4
Rat	exocyst complex component 4
Dog	exocyst complex component 4
Horse	exocyst complex component 4

Protein Structure (0 Structures, 1 AlphaFold Model)

Representation

  axes   backbone   ball+stick   cartoon   rocket   rope   spacefill

Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

AF-Q96A65-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (15)

Reactome (10)

PathwayCommons (3)

WikiPathways (2)

Cargo trafficking to the periciliary membrane (R-HSA-5620920)

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Find Similar Targets

Items per page:

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Cargo trafficking to the periciliary membrane	51 targets	R-HSA-5620920
Reactome	Cilium Assembly	187 targets	R-HSA-5617833
Reactome	Insulin processing	27 targets	R-HSA-264876
Reactome	Membrane Trafficking	612 targets	R-HSA-199991
Reactome	Metabolism of proteins	2050 targets	R-HSA-392499

Name	Explore in Pharos	Explore in Source
Cargo trafficking to the periciliary membrane	51 targets	R-HSA-5620920
Cilium Assembly	187 targets	R-HSA-5617833
Insulin processing	27 targets	R-HSA-264876
Membrane Trafficking	612 targets	R-HSA-199991
Metabolism of proteins	2050 targets	R-HSA-392499

Gene Ontology Terms (21)

Functions (3)

Components (10)

Processes (8)

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Items per page:

10

1 – 3 of 3

GO Term	Evidence	Assigned by
protein N-terminus binding	Inferred from Physical Interaction (IPI)	UniProtKB
Ral GTPase binding	Inferred from Physical Interaction (IPI)	UniProtKB
PDZ domain binding	Inferred from Electronic Annotation (IEA)	Ensembl

Protein-Protein Interactions (147)

Explore Interacting Targets

1 – 10 of 147

• See Interactions on String-DB

EXOC3

Tbio

Novelty: 0.01051955

p_int: 0.999991392

p_ni: 0.000008608

Score: 0.999

Data Source: BioPlex,STRINGDB

EXOC1

Tbio

Novelty: 0.01073858

p_int: 0.999984999

p_ni: 0.000015001

Score: 0.999

Data Source: BioPlex,STRINGDB

TPM1

Tbio

Novelty: 0.00261206

p_int: 0.999884817

p_ni: 0.000115183

Score: 0.276

Data Source: BioPlex,STRINGDB

EXOC6

Tbio

Novelty: 0.01886811

p_int: 0.999603587

p_ni: 0.000396413

Score: 0.999

Data Source: BioPlex,STRINGDB

DTNBP1

Tbio

Novelty: 0.00341619

p_int: 0.998662822

p_ni: 0.001337178

Score: 0.427

Data Source: BioPlex,STRINGDB

STX11

Tbio

Novelty: 0.01670743

p_int: 0.997912424

p_ni: 0.002087576

Score: 0.331

Data Source: BioPlex,STRINGDB

IKBIP

Tbio

Family: Enzyme

Novelty: 0.18707639

p_int: 0.984703911

p_ni: 0.015296089

Data Source: BioPlex

SETDB1

Tbio

Family: TF; Epigenetic

Novelty: 0.00609294

p_int: 0.9837483

p_ni: 0.0162517

Score: 0.197

Data Source: BioPlex,STRINGDB

IL1R2

Tbio

Novelty: 0.00820359

p_int: 0.975975867

p_ni: 0.024024133

Score: 0.664

Data Source: BioPlex,STRINGDB

GGA1

Tbio

Novelty: 0.00866392

p_int: 0.920023242

p_ni: 0.079976758

Score: 0.313

Data Source: BioPlex,STRINGDB

Publication Statistics

PubMed Score  56.19

PubMed score by year

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PubTator Score  33.91

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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UniProt Keyword Find Similar Targets

Acetylation
Alternative splicing
Cell projection
Coiled coil
Complete proteome
Direct protein sequencing
Exocytosis
Phosphoprotein
Polymorphism
Protein transport

GWAS Trait Find Similar Targets

chronotype measurement
cognitive function measurement
diet measurement
household income
intelligence
lifestyle measurement
mathematical ability
mood instability measurement
physical activity measurement
schizophrenia

MGI Phenotype Find Similar Targets

embryo phenotype
growth/size/body region phenotype
mortality/aging