You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
EXOC4
Exocyst complex component 4

Protein Summary
Description
Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and functions of exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. The complex is also essential for the biogenesis of epithelial cell surface polarity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000253861
  • ENSP00000253861
  • ENSG00000131558
  • ENST00000393161
  • ENSP00000376868

Symbol
  • KIAA1699
  • SEC8
  • SEC8L1
  • SEC8
  • Sec8p
  • SEC8L1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
co-expressed gene
0.99
virus perturbation
0.99
kinase perturbation
0.88
transcription factor perturbation
0.88


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.19   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 155   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.19   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 155   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
4
9
10
99.3
self reported educational attainment
6
8
6
4.1
99.2
cognitive function measurement
3
5
6
98.4
intelligence
8
26
15
6
97.6
smoking status measurement
2
1
2
91.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
10
99.3
self reported educational attainment
6
4.1
99.2
cognitive function measurement
6
98.4
intelligence
15
6
97.6
smoking status measurement
2
91.5
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
exocyst complex component 4
VGNC:4342
463740
Mouse
MGI:1096376
20336
Rat
RGD:621791
116654
Dog
exocyst complex component 4
VGNC:40514
482250
Horse
exocyst complex component 4
VGNC:17723
100065209
Species
Name
OMA
EggNOG
Inparanoid
Chimp
exocyst complex component 4
Mouse
Rat
Dog
exocyst complex component 4
Horse
exocyst complex component 4
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q96A65-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (15)
Cargo trafficking to the periciliary membrane (R-HSA-5620920)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cargo trafficking to the periciliary membrane
Reactome
Cilium Assembly
Reactome
Insulin processing
Reactome
Membrane Trafficking
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Cargo trafficking to the periciliary membrane
Cilium Assembly
Insulin processing
Membrane Trafficking
Metabolism of proteins
Gene Ontology Terms (21)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (147)
1 – 10 of 147
EXOC3
Tbio
Novelty: 0.01051955
p_int: 0.999991392
p_ni: 0.000008608
Score: 0.999
Data Source: BioPlex,STRINGDB
EXOC1
Tbio
Novelty: 0.01073858
p_int: 0.999984999
p_ni: 0.000015001
Score: 0.999
Data Source: BioPlex,STRINGDB
TPM1
Tbio
Novelty: 0.00261206
p_int: 0.999884817
p_ni: 0.000115183
Score: 0.276
Data Source: BioPlex,STRINGDB
EXOC6
Tbio
Novelty: 0.01886811
p_int: 0.999603587
p_ni: 0.000396413
Score: 0.999
Data Source: BioPlex,STRINGDB
DTNBP1
Tbio
Novelty: 0.00341619
p_int: 0.998662822
p_ni: 0.001337178
Score: 0.427
Data Source: BioPlex,STRINGDB
STX11
Tbio
Novelty: 0.01670743
p_int: 0.997912424
p_ni: 0.002087576
Score: 0.331
Data Source: BioPlex,STRINGDB
IKBIP
Tbio
Family: Enzyme
Novelty: 0.18707639
p_int: 0.984703911
p_ni: 0.015296089
Data Source: BioPlex
SETDB1
Tbio
Family: TF; Epigenetic
Novelty: 0.00609294
p_int: 0.9837483
p_ni: 0.0162517
Score: 0.197
Data Source: BioPlex,STRINGDB
IL1R2
Tbio
Novelty: 0.00820359
p_int: 0.975975867
p_ni: 0.024024133
Score: 0.664
Data Source: BioPlex,STRINGDB
GGA1
Tbio
Novelty: 0.00866392
p_int: 0.920023242
p_ni: 0.079976758
Score: 0.313
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  56.19

PubMed score by year
PubTator Score  33.91

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: