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Tbio
TP53INP1
Tumor protein p53-inducible nuclear protein 1

Protein Summary
Description
Antiproliferative and proapoptotic protein involved in cell stress response which acts as a dual regulator of transcription and autophagy. Acts as a positive regulator of autophagy. In response to cellular stress or activation of autophagy, relocates to autophagosomes where it interacts with autophagosome-associated proteins GABARAP, GABARAPL1/L2, MAP1LC3A/B/C and regulates autophagy. Acts as an antioxidant and plays a major role in p53/TP53-driven oxidative stress response. Possesses both a p53/TP53-independent intracellular reactive oxygen species (ROS) regulatory function and a p53/TP53-dependent transcription regulatory function. Positively regulates p53/TP53 and p73/TP73 and stimulates their capacity to induce apoptosis and regulate cell cycle. In response to double-strand DNA breaks, promotes p53/TP53 phosphorylation on 'Ser-46' and subsequent apoptosis. Acts as a tumor suppressor by inducing cell death by an autophagy and caspase-dependent mechanism. Can reduce cell migration by ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000342697
  • ENSP00000344215
  • ENSG00000164938
  • ENST00000448464
  • ENSP00000390063

Symbol
  • P53DINP1
  • SIP
  • SIP
  • Teap
  • p53DINP1
  • TP53DINP1
  • TP53INP1A
  • TP53INP1B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
small molecule perturbation
0.94
transcription factor perturbation
0.94
biological process
0.9
PubMedID
0.9
microRNA
0.89


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 251.51   (req: < 5)
Gene RIFs: 39   (req: <= 3)
Antibodies: 322   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 251.51   (req: >= 5)
Gene RIFs: 39   (req: > 3)
Antibodies: 322   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (9)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
RNA Polymerase II Transcription
Reactome
Regulation of TP53 Activity
Reactome
Regulation of TP53 Activity through Phosphorylation
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
RNA Polymerase II Transcription
Regulation of TP53 Activity
Regulation of TP53 Activity through Phosphorylation
Gene Ontology Terms (26)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Protein-Protein Interactions (48)
1 – 10 of 48
ZBTB9
Tdark
Novelty: 1.49438202
p_int: 0.99872463
p_ni: 0.00127537
Score: 0.232
Data Source: BioPlex,STRINGDB
ASPM
Tbio
Novelty: 0.00712035
p_int: 0.976816774
p_ni: 0.023183226
Score: 0.175
Data Source: BioPlex,STRINGDB
TBC1D4
Tbio
Novelty: 0.00751276
p_int: 0.968203948
p_ni: 0.031796052
Score: 0.188
Data Source: BioPlex,STRINGDB
YEATS2
Tbio
Novelty: 0.2764977
p_int: 0.786333757
p_ni: 0.213666243
Score: 0.189
Data Source: BioPlex,STRINGDB
KAT14
Tbio
Novelty: 0.1011236
p_int: 0.769008379
p_ni: 0.229745663
p_wrong: 0.001245958
Score: 0.189
Data Source: BioPlex,STRINGDB
TP53
Tchem
Family: TF
Novelty: 0.00002203
Score: 0.988
Data Source: Reactome,STRINGDB
HIPK2
Tchem
Family: Kinase
Novelty: 0.00813069
Score: 0.972
Data Source: Reactome,STRINGDB
PIN1
Tchem
Family: Enzyme
Novelty: 0.00170157
Score: 0.9
Data Source: Reactome,STRINGDB
NUPR1
Tbio
Novelty: 0.01310579
Score: 0.739
Data Source: STRINGDB
MYC
Tbio
Family: TF
Novelty: 0.000073
Score: 0.58
Data Source: STRINGDB
Publication Statistics
PubMed Score  251.51

PubMed score by year
PubTator Score  112.39

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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