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Tbio
ISL2
Insulin gene enhancer protein ISL-2

Protein Classes
Protein Summary
Description
Transcriptional factor that defines subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000290759
  • ENSP00000290759
  • ENSG00000159556
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.86
transcription factor binding site profile
0.81
transcription factor
0.69
PubMedID
0.61
protein domain
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.08   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 211   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.08   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 211   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking cessation
1
1
1
50.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking cessation
1
50.2
Protein-Protein Interactions (67)
1 – 10 of 67
SSBP3
Tbio
Novelty: 0.01955714
p_int: 0.999999986
p_ni: 1.3e-8
Score: 0.879
Data Source: BioPlex,STRINGDB
SSBP4
Tdark
Novelty: 0.27365687
p_int: 0.999999985
p_ni: 1.4e-8
Score: 0.871
Data Source: BioPlex,STRINGDB
SSBP2
Tbio
Novelty: 0.06546999
p_int: 0.999999826
p_ni: 1.74e-7
Score: 0.874
Data Source: BioPlex,STRINGDB
MFAP4
Tbio
Novelty: 0.02023782
p_int: 0.999980883
p_ni: 0.000018727
p_wrong: 3.9e-7
Data Source: BioPlex
LMO2
Tbio
Novelty: 0.0038279
p_int: 0.999964827
p_ni: 0.000035035
p_wrong: 1.37e-7
Score: 0.671
Data Source: BioPlex,STRINGDB
ARIH1
Tbio
Family: Enzyme
Novelty: 0.0258739
p_int: 0.999935517
p_ni: 0.000023363
p_wrong: 0.000041121
Data Source: BioPlex
EIF1AD
Tdark
Novelty: 0.23915521
p_int: 0.999916553
p_ni: 0.000045991
p_wrong: 0.000037456
Data Source: BioPlex
LHX4
Tbio
Family: TF
Novelty: 0.02047732
p_int: 0.999311138
p_ni: 0.000687985
p_wrong: 8.78e-7
Score: 0.865
Data Source: BioPlex,STRINGDB
IDI2
Tbio
Family: Enzyme
Novelty: 0.02715208
p_int: 0.996997367
p_ni: 0.00294532
p_wrong: 0.000057313
Score: 0.867
Data Source: BioPlex,STRINGDB
EPHA3
Tchem
Family: Kinase
Novelty: 0.00466013
Score: 0.738
Data Source: STRINGDB
Publication Statistics
PubMed Score  24.08

PubMed score by year
PubTator Score  13.98

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer