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Tdark
SPSB4
SPRY domain-containing SOCS box protein 4

Protein Summary
Description
Substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:21199876, PubMed:15601820). Negatively regulates nitric oxide (NO) production and limits cellular toxicity in activated macrophages by mediating the ubiquitination and proteasomal degradation of NOS2 (PubMed:21199876). Acts as a bridge which links NOS2 with the ECS E3 ubiquitin ligase complex components ELOC and CUL5 (PubMed:21199876). Diminishes EphB2-dependent cell repulsive responses by mediating the ubiquitination and degradation of EphB2/CTF2 (PubMed:28931592). Regulates cellular clock function by mediating the ubiquitin/proteasome-dependent degradation of the circadian transcriptional repressor NR1D1 (PubMed:26392558).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000310546
  • ENSP00000311609
  • ENSG00000175093

Symbol
  • SSB4
  • SSB4
  • SSB-4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.92
histone modification site profile
0.67
PubMedID
0.62
protein domain
0.58
transcription factor
0.58


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.66   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 9   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.66   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 9   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
leukocyte count
2
2
2
71.5
myeloid white cell count
1
1
1
50.6
neutrophil count
1
1
1
24.4
granulocyte count
1
1
1
9.7
sum of neutrophil and eosinophil counts
1
1
1
9.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
leukocyte count
2
71.5
myeloid white cell count
1
50.6
neutrophil count
1
24.4
granulocyte count
1
9.7
sum of neutrophil and eosinophil counts
1
9.7
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
splA/ryanodine receptor domain and SOCS box containing 4
VGNC:8845
460739
Mouse
MGI:2183445
211949
Rat
RGD:1562307
300950
Dog
splA/ryanodine receptor domain and SOCS box containing 4
VGNC:46772
485691
Horse
splA/ryanodine receptor domain and SOCS box containing 4
VGNC:23552
100051547
Species
Name
OMA
EggNOG
Inparanoid
Chimp
splA/ryanodine receptor domain and SOCS box containing 4
Mouse
Rat
Dog
splA/ryanodine receptor domain and SOCS box containing 4
Horse
splA/ryanodine receptor domain and SOCS box containing 4
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q96A44-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (8)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Immune System
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Immune System
Metabolism of proteins
Gene Ontology Terms (7)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (320)
1 – 10 of 320
CUL5
Tbio
Novelty:  0.00792494
p_int:  0.804920569
p_ni:  0.000015868
p_wrong:  0.195063563
Score:  0.959
Data Source:  BioPlex,STRINGDB
CISH
Tbio
Novelty:  0.00145893
Score:  0.969
Data Source:  STRINGDB
ELOC
Tbio
Novelty:  0.00964847
Score:  0.968
Data Source:  STRINGDB
LRRC41
Tbio
Novelty:  0.12601472
Score:  0.953
Data Source:  STRINGDB
RNF7
Tbio
Novelty:  0.02532658
Score:  0.944
Data Source:  STRINGDB
WSB1
Tbio
Novelty:  0.04417716
Score:  0.943
Data Source:  STRINGDB
SOCS2
Tbio
Novelty:  0.0044049
Score:  0.941
Data Source:  STRINGDB
ASB6
Tdark
Novelty:  0.32074223
Score:  0.94
Data Source:  STRINGDB
RNF220
Tbio
Family:  Enzyme
Novelty:  0.14024436
Score:  0.936
Data Source:  STRINGDB
SKP1
Tbio
Family:  Enzyme
Novelty:  0.00149739
Score:  0.935
Data Source:  STRINGDB
Publication Statistics
PubMed Score  14.66

PubMed score by year
PubTator Score  1.59

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer