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Tbio
MYLPF
Myosin regulatory light chain 2, skeletal muscle isoform

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IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 88.53   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 160   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 88.53   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 160   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
myosin light chain, phosphorylatable, fast skeletal muscle
107968677
Macaque
myosin light chain, phosphorylatable, fast skeletal muscle
711778
Mouse
MGI:97273
17907
Rat
RGD:3141
24584
Dog
myosin light chain, phosphorylatable, fast skeletal muscle
VGNC:43552
479772
Species
Name
OMA
EggNOG
Inparanoid
Chimp
myosin light chain, phosphorylatable, fast skeletal muscle
Macaque
myosin light chain, phosphorylatable, fast skeletal muscle
Mouse
Rat
Dog
myosin light chain, phosphorylatable, fast skeletal muscle
Pathways (39)
Muscle contraction (R-HSA-397014)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Muscle contraction
Reactome
Smooth Muscle Contraction
Name
Explore in Pharos
Explore in Source
Muscle contraction
Smooth Muscle Contraction
Gene Ontology Terms (8)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (143)
1 – 10 of 143
RSPH6A
Tdark
Novelty: 0.03734897
p_int: 0.999999997
p_ni: 3e-9
Data Source: BioPlex
MECOM
Tbio
Family: TF; Epigenetic
Novelty: 0.00500501
p_int: 0.999999988
p_ni: 1.2e-8
Data Source: BioPlex
ABTB2
Tdark
Novelty: 0.45729157
p_int: 0.999319305
p_ni: 0.000030837
p_wrong: 0.000649858
Data Source: BioPlex
MYLK
Tchem
Family: Kinase
Novelty: 0.00102277
Score: 0.991
Data Source: STRINGDB
ACTA2
Tbio
Novelty: 0.00199354
Score: 0.985
Data Source: STRINGDB
ACTG2
Tbio
Novelty: 0.00304944
Score: 0.984
Data Source: STRINGDB
MYH11
Tbio
Novelty: 0.00142474
Score: 0.976
Data Source: STRINGDB
MYH1
Tbio
Novelty: 0.00472973
Score: 0.974
Data Source: STRINGDB
ACTA1
Tbio
Novelty: 0.00111813
Score: 0.971
Data Source: STRINGDB
MYL1
Tbio
Novelty: 0.00360262
Score: 0.971
Data Source: STRINGDB
Publication Statistics
PubMed Score  88.53

PubMed score by year
PubTator Score  2.78

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer