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Tbio
SLC35C1
GDP-fucose transporter 1

Protein Summary
Description
Involved in GDP-fucose import from the cytoplasm into the Golgi lumen. This gene encodes a GDP-fucose transporter that is found in the Golgi apparatus. Mutations in this gene result in congenital disorder of glycosylation type IIc. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000314134
  • ENSP00000313318
  • ENSG00000181830
  • ENST00000442528
  • ENSP00000412408

Symbol
  • FUCT1
  • CDG2C
  • FUCT1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.84
small molecule perturbation
0.7
disease perturbation
0.68
cell type or tissue
0.67
transcription factor
0.66


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 55   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 55   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (14)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 14
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Reactome
Defective SLC35C1 causes congenital disorder of glycosylation 2C (CDG2C)
Reactome
Disease
Reactome
Disorders of transmembrane transporters
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Defective SLC35C1 causes congenital disorder of glycosylation 2C (CDG2C)
Disease
Disorders of transmembrane transporters
Gene Ontology Terms (9)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (63)
1 – 10 of 63
APOD
Tbio
Novelty: 0.00362142
p_int: 0.79281397
p_ni: 0.20718603
Score: 0.319
Data Source: BioPlex,STRINGDB
SLC35C2
Tdark
Family: Transporter
Novelty: 0.34883721
Score: 0.878
Data Source: STRINGDB
SLC35A1
Tbio
Family: Transporter
Novelty: 0.02585992
Score: 0.815
Data Source: STRINGDB
SLC35B3
Tdark
Family: Transporter
Novelty: 0.12544899
Score: 0.807
Data Source: STRINGDB
SLC35B1
Tdark
Family: Transporter
Novelty: 0.46681922
Score: 0.793
Data Source: STRINGDB
SLC35A3
Tbio
Family: Transporter
Novelty: 0.01205205
Score: 0.755
Data Source: STRINGDB
SLC35B4
Tbio
Family: Transporter
Novelty: 0.01580978
Score: 0.75
Data Source: STRINGDB
RAPGEF5
Tbio
Novelty: 0.02176235
Score: 0.747
Data Source: STRINGDB
MGAT2
Tchem
Family: Enzyme
Novelty: 0.02874448
Score: 0.738
Data Source: STRINGDB
GMDS
Tbio
Family: Enzyme
Novelty: 0.00474944
Score: 0.734
Data Source: STRINGDB
Publication Statistics
PubMed Score  9.00

PubMed score by year
PubTator Score  8.37

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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