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Tbio
ATP6V1E2
V-type proton ATPase subunit E 2

Protein Summary
Description
Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. This isoform is essential for energy coupling involved in acidification of acrosome (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000306448
  • ENSP00000304891
  • ENSG00000250565
  • ENST00000522587
  • ENSP00000428141

Symbol
  • ATP6E1
  • ATP6EL2
  • ATP6V1EL2
  • VMA4
  • ATP6E1
  • ATP6EL2
  • ATP6V1EL2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.96
virus perturbation
0.92
tissue sample
0.61
cell type or tissue
0.57
tissue
0.57


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.99   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 91   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.99   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 91   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (72)
ATP6V1C2
Tbio
Family:  Enzyme
Novelty:  0.07583427
p_int:  0.999999999
p_wrong:  1e-9
Score:  0.999
Data Source:  BioPlex,STRINGDB
ATP6V1D
Tbio
Family:  Enzyme
Novelty:  0.02298626
p_int:  0.999999937
p_ni:  6.3e-8
Score:  0.997
Data Source:  BioPlex,STRINGDB
ATP6V1B1
Tchem
Family:  Enzyme
Novelty:  0.01122589
p_int:  0.999999895
p_wrong:  1.05e-7
Score:  0.999
Data Source:  BioPlex,STRINGDB
ATP6V1H
Tbio
Family:  Enzyme
Novelty:  0.04269105
Score:  0.998
Data Source:  STRINGDB
ATP6V1G1
Tbio
Family:  Enzyme
Novelty:  0.07710789
Score:  0.998
Data Source:  STRINGDB
ATP6V1F
Tbio
Family:  Enzyme
Novelty:  0.07109314
Score:  0.996
Data Source:  STRINGDB
ATP6V1G2
Tbio
Family:  Enzyme
Novelty:  0.10663259
Score:  0.996
Data Source:  STRINGDB
ATP6V1C1
Tbio
Family:  Enzyme
Novelty:  0.03660846
Score:  0.996
Data Source:  STRINGDB
ATP6V1A
Tbio
Family:  Enzyme
Novelty:  0.00921474
Score:  0.996
Data Source:  STRINGDB
ATP6V1B2
Tchem
Family:  Enzyme
Novelty:  0.01767911
Score:  0.996
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (21)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Insulin receptor recycling
Reactome
Ion channel transport
Reactome
Iron uptake and transport
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Insulin receptor recycling
Ion channel transport
Iron uptake and transport
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
gait measurement
1
1
1
17.8
hematocrit
1
1
1
6.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
gait measurement
1
17.8
hematocrit
1
6.9
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ATPase H+ transporting V1 subunit E2
VGNC:175
100612241
Macaque
ATPase H+ transporting V1 subunit E2
714746
Mouse
MGI:1922165
74915
Rat
RGD:1311680
366545
Dog
ATPase H+ transporting V1 subunit E2
VGNC:38281
481359
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ATPase H+ transporting V1 subunit E2
Macaque
ATPase H+ transporting V1 subunit E2
Mouse
Rat
Dog
ATPase H+ transporting V1 subunit E2
Publication Statistics
PubMed Score 8.99
PubMed score by year
PubTator Score 0.50
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title