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Tbio
RELT
Tumor necrosis factor receptor superfamily member 19L

Protein Summary
Description
May play a role in apoptosis (PubMed:28688764, PubMed:19969290). Induces activation of MAPK14/p38 and MAPK8/JNK MAPK cascades, when overexpressed (PubMed:16530727). The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is especially abundant in hematologic tissues. It has been shown to activate the NF-kappaB pathway and selectively bind TNF receptor-associated factor 1 (TRAF1). This receptor is capable of stimulating T-cell proliferation in the presence of CD3 signaling, which suggests its regulatory role in immune response. Two alternatively spliced transcript variants of this gene encoding the same protein have been reported. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000064780
  • ENSP00000064780
  • ENSG00000054967
  • ENST00000393580
  • ENSP00000377207

Symbol
  • TNFRSF19L
  • TRLT
  • TNFRSF19L
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.89
transcription factor
0.83
cell type or tissue
0.72
cell line
0.67
tissue sample
0.57


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.43   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 341   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.43   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 341   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
FEV/FEC ratio
1
1
1
75
forced expiratory volume
1
1
1
61
diastolic blood pressure
1
1
1
29
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
FEV/FEC ratio
1
75
forced expiratory volume
1
61
diastolic blood pressure
1
29
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RELT, TNF receptor
VGNC:3063
466703
Macaque
RELT, TNF receptor
718143
Mouse
MGI:2443373
320100
Rat
RGD:1305381
361615
Dog
RELT, TNF receptor
VGNC:45471
485200
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RELT, TNF receptor
Macaque
RELT, TNF receptor
Mouse
Rat
Dog
RELT, TNF receptor
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q969Z4-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (5)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HPA
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Protein-Protein Interactions (42)
1 – 10 of 42
STK39
Tchem
Family:  Kinase
Novelty:  0.00548476
p_int:  0.999999737
p_ni:  2.63e-7
Score:  0.825
Data Source:  BioPlex,STRINGDB
OXSR1
Tbio
Family:  Kinase
Novelty:  0.11142923
p_int:  0.999993774
p_ni:  0.000006226
Score:  0.988
Data Source:  BioPlex,STRINGDB
RELL2
Tbio
Novelty:  0.59290726
p_int:  0.999858482
p_ni:  0.000141471
p_wrong:  4.7e-8
Score:  0.759
Data Source:  BioPlex,STRINGDB
MANSC1
Tdark
Novelty:  0.91681036
p_int:  0.999393932
p_ni:  0.000606056
p_wrong:  1.3e-8
Data Source:  BioPlex
MAS1
Tchem
Family:  GPCR
Novelty:  0.0089712
p_int:  0.996772285
p_ni:  0.003227183
p_wrong:  5.32e-7
Data Source:  BioPlex
HEPACAM2
Tbio
Novelty:  0.19192547
p_int:  0.996526388
p_ni:  0.003473023
p_wrong:  5.88e-7
Score:  0.204
Data Source:  BioPlex,STRINGDB
C16orf58
Tdark
Novelty:  0.34461652
p_int:  0.993581876
p_ni:  0.006412923
p_wrong:  0.000005201
Data Source:  BioPlex
RAB11FIP1
Tbio
Novelty:  0.0445306
p_int:  0.992678056
p_ni:  0.007321944
Score:  0.303
Data Source:  BioPlex,STRINGDB
TGFBR2
Tchem
Family:  Kinase
Novelty:  0.00085381
p_int:  0.990789375
p_ni:  0.002299616
p_wrong:  0.006911009
Score:  0.226
Data Source:  BioPlex,STRINGDB
TPCN2
Tchem
Family:  IC
Novelty:  0.01351129
p_int:  0.990022683
p_ni:  0.002224194
p_wrong:  0.007753122
Data Source:  BioPlex
Publication Statistics
PubMed Score  16.43

PubMed score by year
PubTator Score  8.1

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer