You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
GTPBP3
tRNA modification GTPase GTPBP3, mitochondrial

Protein Summary
Description
GTPase involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U34) of the wobble uridine base in mitochondrial tRNAs. This locus encodes a GTP-binding protein. The encoded protein is localized to the mitochondria and may play a role in mitochondrial tRNA modification. Polymorphisms at this locus may be associated with severity of aminoglycoside-induced deafness, a disease associated with a mutation in the 12S rRNA. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Sep 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000324894
  • ENSP00000313818
  • ENSG00000130299
  • ENST00000358792
  • ENSP00000351644
  • ENST00000361619
  • ENSP00000354598
  • ENST00000600625
  • ENSP00000473150

Symbol
  • MTGP1
  • MSS1
  • MTGP1
  • THDF1
  • GTPBG3
  • COXPD23
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
molecular function
0.91
transcription factor binding site profile
0.81
transcription factor
0.68
virus perturbation
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.99   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 101   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.99   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 101   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (102)
1 – 10 of 102
EPHA1
Tchem
Family:  Kinase
Novelty:  0.00136672
p_int:  0.985771873
p_ni:  0.014228127
Data Source:  BioPlex
ELAVL2
Tbio
Novelty:  0.00370708
p_int:  0.957479239
p_ni:  0.042520761
Data Source:  BioPlex
SPINT2
Tbio
Family:  Enzyme
Novelty:  0.0046602
p_int:  0.9546779
p_ni:  0.0453221
Data Source:  BioPlex
LPCAT2
Tbio
Family:  Enzyme
Novelty:  0.02794035
p_int:  0.892776291
p_ni:  0.107223709
Data Source:  BioPlex
KLK14
Tchem
Family:  Enzyme
Novelty:  0.02007434
p_int:  0.874260627
p_ni:  0.125739373
Data Source:  BioPlex
CPM
Tchem
Family:  Enzyme
Novelty:  0.00520702
p_int:  0.826491669
p_ni:  0.173508331
Score:  0.282
Data Source:  BioPlex,STRINGDB
MTO1
Tbio
Novelty:  0.0229161
Score:  0.989
Data Source:  STRINGDB
TRMU
Tbio
Family:  Enzyme
Novelty:  0.01615197
Score:  0.933
Data Source:  STRINGDB
TFB1M
Tbio
Family:  Enzyme
Novelty:  0.0236373
Score:  0.797
Data Source:  STRINGDB
GTPBP4
Tchem
Novelty:  0.00062563
Score:  0.72
Data Source:  STRINGDB
Pathways (3)
Metabolism of RNA (R-HSA-8953854)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
tRNA modification in the mitochondrion
Reactome
tRNA processing
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
tRNA modification in the mitochondrion
tRNA processing
Gene Ontology Terms (7)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
6
4
0
1.2
93.9
testosterone measurement
4
2
4
92.7
2
3
0
1.2
92.6
mitochondrial DNA measurement
2
3
3
90
sex hormone-binding globulin measurement
6
1
6
88.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.2
93.9
testosterone measurement
4
92.7
0
1.2
92.6
mitochondrial DNA measurement
3
90
sex hormone-binding globulin measurement
6
88.2
Find similar targets by:
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
GTP binding protein 3, mitochondrial
719758
Mouse
MGI:1917609
70359
Rat
RGD:1305367
290633
Dog
GTP binding protein 3, mitochondrial
VGNC:54309
484838
Horse
GTP binding protein 3, mitochondrial [Source:HGNC Symbol;Acc:HGNC:14880]
Species
Name
OMA
EggNOG
Inparanoid
Macaque
GTP binding protein 3, mitochondrial
Mouse
Rat
Dog
GTP binding protein 3, mitochondrial
Horse
GTP binding protein 3, mitochondrial [Source:HGNC Symbol;Acc:HGNC:14880]
Publication Statistics
PubMed Score 14.99
PubMed score by year
PubTator Score 12.64
PubTator score by year