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Tbio
UTP4
U3 small nucleolar RNA-associated protein 4 homolog

Protein Summary
Description
Ribosome biogenesis factor. Involved in nucleolar processing of pre-18S ribosomal RNA. Involved in small subunit (SSU) pre-rRNA processing at sites A', A0, 1 and 2b. Required for optimal pre-ribosomal RNA transcription by RNA polymerase (PubMed:17699751, PubMed:19732766). May be a transcriptional regulator. Acts as a positive regulator of HIVEP1 which specifically binds to the DNA sequence 5'-GGGACTTTCC-3' found in enhancer elements of numerous viral promoters such as those of HIV-1, SV40, or CMV (PubMed:19732766). This gene encodes a WD40-repeat-containing protein that is localized to the nucleolus. Mutation of this gene causes North American Indian childhood cirrhosis, a severe intrahepatic cholestasis that results in transient neonatal jaundice, and progresses to periportal fibrosis and cirrhosis in childhood and adolescence. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000314423
  • ENSP00000327179
  • ENSG00000141076
  • ENST00000352319
  • ENSP00000339164
  • ENST00000563094
  • ENSP00000456622
  • ENST00000575702
  • ENSP00000458843
  • ENSG00000262788

Symbol
  • CIRH1A
  • cPERP-E
  • KIAA1988
  • NAIC
  • CIRH1A
  • CIRHIN
  • TEX292
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.71   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 114   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.71   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 114   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (338)
WDR43
Tbio
Novelty:  0.12680949
p_int:  0.99999987
p_ni:  1.26e-7
p_wrong:  4e-9
Score:  0.999
Data Source:  BioPlex,STRINGDB
NOL11
Tbio
Novelty:  0.47253767
p_int:  0.999999611
p_ni:  3.75e-7
p_wrong:  1.4e-8
Score:  0.997
Data Source:  BioPlex,STRINGDB
UTP15
Tbio
Novelty:  0.08174586
p_int:  0.999999504
p_ni:  4.96e-7
Score:  0.999
Data Source:  BioPlex,STRINGDB
WDR75
Tbio
Novelty:  0.09443914
p_int:  0.999993819
p_ni:  0.00000618
p_wrong:  1e-9
Score:  0.999
Data Source:  BioPlex,STRINGDB
CNRIP1
Tbio
Novelty:  0.06888531
p_int:  0.99999267
p_ni:  0.00000733
Score:  0.219
Data Source:  BioPlex,STRINGDB
NECAB1
Tbio
Novelty:  0.24384799
p_int:  0.999991596
p_ni:  0.000008404
Score:  0.157
Data Source:  BioPlex,STRINGDB
PAGE1
Tbio
Novelty:  0.02731969
p_int:  0.999916003
p_ni:  0.000083997
Data Source:  BioPlex
GOLGA4
Tbio
Novelty:  0.01363253
p_int:  0.999279065
p_ni:  0.000720935
Score:  0.527
Data Source:  BioPlex,STRINGDB
NOL7
Tbio
Novelty:  0.24085052
p_int:  0.997231836
p_ni:  0.002768164
Score:  0.883
Data Source:  BioPlex,STRINGDB
ANKRD28
Tbio
Family:  Enzyme
Novelty:  0.10895759
p_int:  0.989800654
p_ni:  0.010199346
Score:  0.201
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Major pathway of rRNA processing in the nucleolus and cytosol (R-HSA-6791226)

Click on a row in the table to change the structure displayed.

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Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Major pathway of rRNA processing in the nucleolus and cytosol
Reactome
Metabolism of RNA
Reactome
rRNA modification in the nucleus and cytosol
Reactome
rRNA processing
Reactome
rRNA processing in the nucleus and cytosol
Name
Explore in Pharos
Explore in Source
Major pathway of rRNA processing in the nucleolus and cytosol
Metabolism of RNA
rRNA modification in the nucleus and cytosol
rRNA processing
rRNA processing in the nucleus and cytosol
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (12)
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Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
1
1
1
42.3
high density lipoprotein cholesterol measurement
1
1
1
40.7
diastolic blood pressure
1
1
1
12.2
heel bone mineral density
1
1
1
10.6
alcohol consumption measurement
2
1
2
8.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
1
42.3
high density lipoprotein cholesterol measurement
1
40.7
diastolic blood pressure
1
12.2
heel bone mineral density
1
10.6
alcohol consumption measurement
2
8.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
UTP4, small subunit processome component
VGNC:51234
454197
Macaque
UTP4, small subunit processome component
705036
Mouse
MGI:1096573
21771
Rat
RGD:1311341
291987
Dog
UTP4, small subunit processome component
489738
Species
Name
OMA
EggNOG
Inparanoid
Chimp
UTP4, small subunit processome component
Macaque
UTP4, small subunit processome component
Mouse
Rat
Dog
UTP4, small subunit processome component
Publication Statistics
PubMed Score 18.71
PubMed score by year
PubTator Score 13.61
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title