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Tdark
ST6GALNAC6
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6

Protein Summary
Description
Alpha-2,6-sialyltransferase involved in the synthesis of alpha-series gangliosides. Has activity toward GD1a, GT1b and GM1b. Has no activity toward glycoproteins. Responsible for the biosynthesis of DSGG (disialylgalactosylgloboside) from MSGG (monosialylgalactosylgloboside) in normal and malignant kidney. Participates in the synthesis of disialyl Lewis a (Le(a)). ST6GALNAC6 belongs to a family of sialyltransferases that modify proteins and ceramides on the cell surface to alter cell-cell or cell-extracellular matrix interactions (Tsuchida et al., 2003 [PubMed 12668675]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000291839
  • ENSP00000291839
  • ENSG00000160408
  • ENST00000373141
  • ENSP00000362234
  • ENST00000373142
  • ENSP00000362235
  • ENST00000373144
  • ENSP00000362237
  • ENST00000373146
  • ENSP00000362239
  • ENST00000622357
  • ENSP00000477575

Symbol
  • SIAT7F
  • SIAT7F
  • SIAT7-F
  • ST6GALNACVI
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.91
cell type or tissue
0.77
virus perturbation
0.72
cellular component
0.6
transcription factor
0.59


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.98   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 83   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.98   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 83   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 6
VGNC:13969
450107
Macaque
ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 6
706120
Mouse
MGI:1355316
50935
Dog
ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 6
VGNC:46862
491324
Horse
ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 6
VGNC:23638
100070405
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 6
Macaque
ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 6
Mouse
Dog
ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 6
Horse
ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 6
Pathways (14)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Reactome
Blood group systems biosynthesis
Reactome
Lewis blood group biosynthesis
Reactome
Metabolism
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Blood group systems biosynthesis
Lewis blood group biosynthesis
Metabolism
Protein-Protein Interactions (59)
1 – 10 of 59
B3GALT1
Tbio
Family: Enzyme
Novelty: 0.14518755
Score: 0.758
Data Source: STRINGDB
B4GALNT2
Tbio
Family: Enzyme
Novelty: 0.00499206
Score: 0.755
Data Source: STRINGDB
B4GALT1
Tbio
Family: Enzyme
Novelty: 0.0073693
Score: 0.743
Data Source: STRINGDB
LGALS7
Tbio
Novelty: 0.00753996
Score: 0.676
Data Source: STRINGDB
C1GALT1
Tbio
Family: Enzyme
Novelty: 0.01191596
Score: 0.63
Data Source: STRINGDB
LALBA
Tbio
Family: Enzyme
Novelty: 0.00037262
Score: 0.624
Data Source: STRINGDB
NANS
Tbio
Family: Enzyme
Novelty: 0.00718044
Score: 0.613
Data Source: STRINGDB
GALNT7
Tbio
Family: Enzyme
Novelty: 0.05328171
Score: 0.6
Data Source: STRINGDB
GALNT15
Tbio
Family: Enzyme
Novelty: 0.05370972
Score: 0.595
Data Source: STRINGDB
GCNT1
Tbio
Family: Enzyme
Novelty: 0.01487872
Score: 0.592
Data Source: STRINGDB
Publication Statistics
PubMed Score  4.98

PubMed score by year
PubTator Score  2.33

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer