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Tbio
PMEPA1
Protein TMEPAI

Protein Summary
Description
Functions as a negative regulator of TGF-beta signaling and thereby probably plays a role in cell proliferation, differentiation, apoptosis, motility, extracellular matrix production and immunosuppression. In the canonical TGF-beta pathway, ZFYVE9/SARA recruits the intracellular signal transducer and transcriptional modulators SMAD2 and SMAD3 to the TGF-beta receptor. Phosphorylated by the receptor, SMAD2 and SMAD3 then form a heteromeric complex with SMAD4 that translocates to the nucleus to regulate transcription. Through interaction with SMAD2 and SMAD3, LDLRAD4 may compete with ZFYVE9 and SMAD4 and prevent propagation of the intracellular signal (PubMed:20129061, PubMed:24627487). Also involved in down-regulation of the androgen receptor (AR), enhancing ubiquitination and proteasome-mediated degradation of AR, probably by recruiting NEDD4 (PubMed:18703514). This gene encodes a transmembrane protein that contains a Smad interacting motif (SIM). Expression of this gene is induced by ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265626
  • ENSP00000265626
  • ENSG00000124225
  • ENST00000341744
  • ENSP00000345826
  • ENST00000347215
  • ENSP00000344014
  • ENST00000395814
  • ENSP00000379159
  • ENST00000395816
  • ENSP00000379161

Symbol
  • STAG1
  • TMEPAI
  • STAG1
  • TMEPAI
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
1
gene perturbation
0.85
kinase perturbation
0.76
PubMedID
0.76
virus perturbation
0.76


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 54.56   (req: < 5)
Gene RIFs: 25   (req: <= 3)
Antibodies: 139   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 54.56   (req: >= 5)
Gene RIFs: 25   (req: > 3)
Antibodies: 139   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
2
2
2
90.2
hemoglobin measurement
1
1
1
76.5
glomerular filtration rate
3
1
3
73.3
triglyceride measurement
2
1
2
61.4
BMI-adjusted waist-hip ratio
1
1
1
17.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
2
90.2
hemoglobin measurement
1
76.5
glomerular filtration rate
3
73.3
triglyceride measurement
2
61.4
BMI-adjusted waist-hip ratio
1
17.8
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
prostate transmembrane protein, androgen induced 1
695968
Mouse
MGI:1929600
65112
Rat
RGD:1308255
311676
Dog
prostate transmembrane protein, androgen induced 1
VGNC:44731
485945
Horse
prostate transmembrane protein, androgen induced 1
VGNC:51593
100055800
Species
Name
OMA
EggNOG
Inparanoid
Macaque
prostate transmembrane protein, androgen induced 1
Mouse
Rat
Dog
prostate transmembrane protein, androgen induced 1
Horse
prostate transmembrane protein, androgen induced 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q969W9-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (5)
Downregulation of TGF-beta receptor signaling (R-HSA-2173788)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Downregulation of TGF-beta receptor signaling
Reactome
Signal Transduction
Reactome
Signaling by TGF-beta Receptor Complex
Reactome
Signaling by TGF-beta family members
Reactome
TGF-beta receptor signaling activates SMADs
Name
Explore in Pharos
Explore in Source
Downregulation of TGF-beta receptor signaling
Signal Transduction
Signaling by TGF-beta Receptor Complex
Signaling by TGF-beta family members
TGF-beta receptor signaling activates SMADs
Gene Ontology Terms (12)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Protein-Protein Interactions (31)
1 – 10 of 31
SMAD2
Tbio
Family:  TF
Novelty:  0.00040166
Score:  0.94
Data Source:  Reactome,STRINGDB
SMAD3
Tchem
Family:  TF
Novelty:  0.00048058
Score:  0.936
Data Source:  Reactome,STRINGDB
AR
Tclin
Family:  NR
Novelty:  0.00013531
Score:  0.802
Data Source:  STRINGDB
NEDD4
Tchem
Family:  Enzyme
Novelty:  0.00281725
Score:  0.712
Data Source:  STRINGDB
KLK3
Tclin
Family:  Enzyme
Novelty:  0.00003606
Score:  0.667
Data Source:  STRINGDB
TMEM150C
Tdark
Novelty:  0.11603552
Score:  0.624
Data Source:  STRINGDB
DCTN6
Tdark
Novelty:  0.30624393
Score:  0.623
Data Source:  STRINGDB
KLK2
Tchem
Family:  Enzyme
Novelty:  0.00511717
Score:  0.612
Data Source:  STRINGDB
RBM38
Tbio
Novelty:  0.03491566
Score:  0.575
Data Source:  STRINGDB
GPRIN1
Tbio
Novelty:  0.14698407
Score:  0.572
Data Source:  STRINGDB
Publication Statistics
PubMed Score  54.56

PubMed score by year
PubTator Score  30.07

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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