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Tbio
PMEPA1
Protein TMEPAI

Protein Summary
Description
Functions as a negative regulator of TGF-beta signaling and thereby probably plays a role in cell proliferation, differentiation, apoptosis, motility, extracellular matrix production and immunosuppression. In the canonical TGF-beta pathway, ZFYVE9/SARA recruits the intracellular signal transducer and transcriptional modulators SMAD2 and SMAD3 to the TGF-beta receptor. Phosphorylated by the receptor, SMAD2 and SMAD3 then form a heteromeric complex with SMAD4 that translocates to the nucleus to regulate transcription. Through interaction with SMAD2 and SMAD3, LDLRAD4 may compete with ZFYVE9 and SMAD4 and prevent propagation of the intracellular signal (PubMed:20129061, PubMed:24627487). Also involved in down-regulation of the androgen receptor (AR), enhancing ubiquitination and proteasome-mediated degradation of AR, probably by recruiting NEDD4 (PubMed:18703514). This gene encodes a transmembrane protein that contains a Smad interacting motif (SIM). Expression of this gene is induced by ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265626
  • ENSP00000265626
  • ENSG00000124225
  • ENST00000341744
  • ENSP00000345826
  • ENST00000347215
  • ENSP00000344014
  • ENST00000395814
  • ENSP00000379159
  • ENST00000395816
  • ENSP00000379161

Symbol
  • STAG1
  • TMEPAI
  • STAG1
  • TMEPAI
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
1
gene perturbation
0.85
kinase perturbation
0.76
PubMedID
0.76
virus perturbation
0.76


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.58   (req: < 5)
Gene RIFs: 25   (req: <= 3)
Antibodies: 139   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.58   (req: >= 5)
Gene RIFs: 25   (req: > 3)
Antibodies: 139   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0