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Tbio
NCLN
Nicalin

Protein Summary
Description
May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning.
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.84
transcription factor binding site profile
0.82
tissue sample
0.72
histone modification site profile
0.71
disease perturbation
0.68


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.27   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 125   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.27   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 125   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (68)
NOMO2
Tdark
Novelty:  0.17781596
p_int:  1
Score:  0.958
Data Source:  BioPlex,STRINGDB
NOMO1
Tbio
Novelty:  0.13625697
p_int:  0.999916003
p_ni:  0.000083997
Score:  0.872
Data Source:  BioPlex,STRINGDB
FPR2
Tchem
Family:  GPCR
Novelty:  0.00228744
p_int:  0.924176208
p_ni:  0.075823792
Data Source:  BioPlex
CMKLR1
Tchem
Family:  GPCR
Novelty:  0.00893083
p_int:  0.86478959
p_ni:  0.13521041
Data Source:  BioPlex
TMEM106A
Tbio
Novelty:  0.32470607
p_int:  0.862941966
p_ni:  0.137058034
Data Source:  BioPlex
DLK1
Tchem
Novelty:  0.00212394
p_int:  0.795462039
p_ni:  0.204537961
Score:  0.165
Data Source:  BioPlex,STRINGDB
GLMP
Tdark
Novelty:  0.10163099
p_int:  0.766936028
p_ni:  0.233063972
Score:  0.186
Data Source:  BioPlex,STRINGDB
TMEM147
Tbio
Novelty:  0.39056101
Score:  0.985
Data Source:  STRINGDB
EPRS
Tchem
Family:  Enzyme
Novelty:  0.00084896
Score:  0.872
Data Source:  STRINGDB
RPN2
Tbio
Family:  Enzyme
Novelty:  0.01796569
Score:  0.847
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (25)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
4
4
5
97.9
leukocyte count
2
4
4
97.8
myeloid white cell count
2
2
2
95.4
eosinophil count
3
2
4
92.2
eosinophil percentage of leukocytes
2
2
3
90.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
5
97.9
leukocyte count
4
97.8
myeloid white cell count
2
95.4
eosinophil count
4
92.2
eosinophil percentage of leukocytes
3
90.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
nicalin
VGNC:2305
468663
Macaque
nicalin
712703
Mouse
MGI:1926081
103425
Rat
RGD:1309355
314648
Dog
nicalin
VGNC:43658
485062
Species
Name
OMA
EggNOG
Inparanoid
Chimp
nicalin
Macaque
nicalin
Mouse
Rat
Dog
nicalin
Publication Statistics
PubMed Score 10.27
PubMed score by year
PubTator Score 3.58
PubTator score by year
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Related Publications
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PMID
Year
Title