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Tchem
MCHR2
Melanin-concentrating hormone receptor 2

Protein Summary
Description
Receptor for melanin-concentrating hormone, coupled to G proteins that activate phosphoinositide hydrolysis.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000281806
  • ENSP00000281806
  • ENSG00000152034
  • ENST00000369212
  • ENSP00000358214

Symbol
  • GPR145
  • SLT
  • SLT
  • MCH2
  • MCH2R
  • GPR145
  • GPRv17
  • MCH-2R
  • MCH-R2
  • MCHR-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.58
cell line
0.55
cell type or tissue
0.52
phenotype
0.45
microRNA
0.44


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 82.82   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 184   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 82.82   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 184   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 29
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (356)
TAS2R7
Tchem
Family:  GPCR
Novelty:  0.10029148
Score:  0.961
Data Source:  STRINGDB
PMCH
Tbio
Novelty:  0.00600873
Score:  0.96
Data Source:  Reactome,STRINGDB
UTS2
Tbio
Novelty:  0.00279068
Score:  0.956
Data Source:  STRINGDB
TAS2R4
Tchem
Family:  GPCR
Novelty:  0.02938385
Score:  0.955
Data Source:  STRINGDB
GNAQ
Tbio
Novelty:  0.0008997
Score:  0.955
Data Source:  STRINGDB
HRH3
Tclin
Family:  GPCR
Novelty:  0.00148904
Score:  0.953
Data Source:  STRINGDB
ADRA1D
Tclin
Family:  GPCR
Novelty:  0.00203304
Score:  0.943
Data Source:  STRINGDB
TAS2R14
Tchem
Family:  GPCR
Novelty:  0.02934329
Score:  0.937
Data Source:  STRINGDB
TAS2R8
Tchem
Family:  GPCR
Novelty:  0.18059853
Score:  0.937
Data Source:  STRINGDB
NPY5R
Tchem
Family:  GPCR
Novelty:  0.01747655
Score:  0.935
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (12)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (i) signalling events
Reactome
G alpha (q) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
G alpha (q) signalling events
GPCR downstream signalling
GPCR ligand binding
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
2
1
2
12.3
enuresis
1
1
0
1.2
11.8
age at first sexual intercourse measurement
1
1
1
9.4
alcohol consumption measurement
1
1
1
0.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
2
12.3
enuresis
0
1.2
11.8
age at first sexual intercourse measurement
1
9.4
alcohol consumption measurement
1
0.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
melanin concentrating hormone receptor 2
VGNC:3456
472082
Macaque
melanin concentrating hormone receptor 2
574369
Dog
melanin concentrating hormone receptor 2
VGNC:43077
403562
Horse
melanin concentrating hormone receptor 2
VGNC:51051
100066146
Cow
melanin concentrating hormone receptor 2
VGNC:53797
782111
Species
Name
OMA
EggNOG
Inparanoid
Chimp
melanin concentrating hormone receptor 2
Macaque
melanin concentrating hormone receptor 2
Dog
melanin concentrating hormone receptor 2
Horse
melanin concentrating hormone receptor 2
Cow
melanin concentrating hormone receptor 2
Publication Statistics
PubMed Score 82.82
PubMed score by year
PubTator Score 69.67
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title