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Tbio
FBXW5
F-box/WD repeat-containing protein 5

Protein Summary
Description
Substrate recognition component of both SCF (SKP1-CUL1-F-box protein) and DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes. Substrate recognition component of the SCF(FBXW5) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SASS6 during S phase, leading to prevent centriole reduplication. The SCF(FBXW5) complex also mediates ubiquitination and degradation of actin-regulator EPS8 during G2 phase, leading to the transient degradation of EPS8 and subsequent cell shape changes required to allow mitotic progression. Substrate-specific adapter of the DCX(FBXW5) E3 ubiquitin-protein ligase complex which mediates the polyubiquitination and subsequent degradation of TSC2. May also act as a negative regulator of MAP3K7/TAK1 signaling in the interleukin-1B (IL1B) signaling pathway. This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. Th ...more
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.79
transcription factor binding site profile
0.67
cell line
0.59
protein domain
0.58
tissue sample
0.57


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.33   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 139   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.33   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 139   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (391)
SKP1
Tbio
Family:  Enzyme
Novelty:  0.00149739
p_int:  0.999998829
p_ni:  0.000001171
Score:  0.967
Data Source:  BioPlex,STRINGDB
DEFB1
Tbio
Novelty:  0.00144458
p_int:  0.999993122
p_ni:  0.000006841
p_wrong:  3.8e-8
Score:  0.188
Data Source:  BioPlex,STRINGDB
NDEL1
Tbio
Novelty:  0.01241819
p_int:  0.999971797
p_ni:  0.000028203
Data Source:  BioPlex
O43687
Tbio
Family:  Enzyme
Novelty:  0.04114095
p_int:  0.999879649
p_ni:  0.000120306
p_wrong:  4.5e-8
Data Source:  BioPlex
ZNRF1
Tbio
Family:  Enzyme
Novelty:  0.15739853
p_int:  0.999824536
p_ni:  0.000175444
p_wrong:  2e-8
Score:  0.917
Data Source:  BioPlex,STRINGDB
WDR20
Tbio
Novelty:  0.03031804
p_int:  0.99974693
p_ni:  0.000253008
p_wrong:  6.2e-8
Score:  0.163
Data Source:  BioPlex,STRINGDB
NEFM
Tbio
Novelty:  0.00239134
p_int:  0.999444293
p_ni:  0.000555699
p_wrong:  8e-9
Data Source:  BioPlex
ODF3L2
Tdark
Novelty:  1.4355239
p_int:  0.998240305
p_ni:  0.001423056
p_wrong:  0.000336639
Score:  0.232
Data Source:  BioPlex,STRINGDB
SRFBP1
Tbio
Novelty:  0.10070972
p_int:  0.997214495
p_ni:  0.000200414
p_wrong:  0.002585091
Score:  0.261
Data Source:  BioPlex,STRINGDB
PPP3R2
Tbio
Novelty:  0.01121867
p_int:  0.994882937
p_ni:  0.004575482
p_wrong:  0.000541581
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (55)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Association of TriC/CCT with target proteins during biosynthesis
Reactome
Chaperonin-mediated protein folding
Reactome
Class I MHC mediated antigen processing & presentation
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Association of TriC/CCT with target proteins during biosynthesis
Chaperonin-mediated protein folding
Class I MHC mediated antigen processing & presentation
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
4
5
5
90
central corneal thickness
3
2
0
2.9
84
monocyte percentage of leukocytes
2
2
2
78.5
lymphocyte count
2
2
3
68.7
renal system measurement
1
1
1
62.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
5
90
central corneal thickness
0
2.9
84
monocyte percentage of leukocytes
2
78.5
lymphocyte count
3
68.7
renal system measurement
1
62.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
F-box and WD repeat domain containing 5
VGNC:4732
464877
Macaque
F-box and WD repeat domain containing 5
721653
Mouse
MGI:1354731
30839
Rat
RGD:1305661
362081
Dog
F-box and WD repeat domain containing 5
VGNC:40796
491243
Species
Name
OMA
EggNOG
Inparanoid
Chimp
F-box and WD repeat domain containing 5
Macaque
F-box and WD repeat domain containing 5
Mouse
Rat
Dog
F-box and WD repeat domain containing 5
Publication Statistics
PubMed Score 10.33
PubMed score by year
PubTator Score 4.16
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title