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Tbio
FBXW5
F-box/WD repeat-containing protein 5

Protein Summary
Description
Substrate recognition component of both SCF (SKP1-CUL1-F-box protein) and DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes. Substrate recognition component of the SCF(FBXW5) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SASS6 during S phase, leading to prevent centriole reduplication. The SCF(FBXW5) complex also mediates ubiquitination and degradation of actin-regulator EPS8 during G2 phase, leading to the transient degradation of EPS8 and subsequent cell shape changes required to allow mitotic progression. Substrate-specific adapter of the DCX(FBXW5) E3 ubiquitin-protein ligase complex which mediates the polyubiquitination and subsequent degradation of TSC2. May also act as a negative regulator of MAP3K7/TAK1 signaling in the interleukin-1B (IL1B) signaling pathway. This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. Th ...more
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.79
transcription factor binding site profile
0.67
cell line
0.59
protein domain
0.58
tissue sample
0.57


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.83   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 139   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.83   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 139   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
1
1
1
21
heel bone mineral density
1
1
1
16.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
1
21
heel bone mineral density
1
16.4
Pathways (55)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Association of TriC/CCT with target proteins during biosynthesis
Reactome
Chaperonin-mediated protein folding
Reactome
Class I MHC mediated antigen processing & presentation
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Association of TriC/CCT with target proteins during biosynthesis
Chaperonin-mediated protein folding
Class I MHC mediated antigen processing & presentation
Gene Ontology Terms (13)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Physical Interaction (IPI)
UniProtKB
Protein-Protein Interactions (391)
1 – 10 of 391
SKP1
Tbio
Family: Enzyme
Novelty: 0.00149739
p_int: 0.999998829
p_ni: 0.000001171
Score: 0.967
Data Source: BioPlex,STRINGDB
DEFB1
Tbio
Novelty: 0.00144458
p_int: 0.999993122
p_ni: 0.000006841
p_wrong: 3.8e-8
Score: 0.188
Data Source: BioPlex,STRINGDB
NDEL1
Tbio
Novelty: 0.01241819
p_int: 0.999971797
p_ni: 0.000028203
Data Source: BioPlex
AKAP7
Tbio
Family: Enzyme
Novelty: 0.04114095
p_int: 0.999879649
p_ni: 0.000120306
p_wrong: 4.5e-8
Data Source: BioPlex
ZNRF1
Tbio
Family: Enzyme
Novelty: 0.15739853
p_int: 0.999824536
p_ni: 0.000175444
p_wrong: 2e-8
Score: 0.917
Data Source: BioPlex,STRINGDB
WDR20
Tbio
Novelty: 0.03031804
p_int: 0.99974693
p_ni: 0.000253008
p_wrong: 6.2e-8
Score: 0.163
Data Source: BioPlex,STRINGDB
NEFM
Tbio
Novelty: 0.00239134
p_int: 0.999444293
p_ni: 0.000555699
p_wrong: 8e-9
Data Source: BioPlex
ODF3L2
Tdark
Novelty: 1.4355239
p_int: 0.998240305
p_ni: 0.001423056
p_wrong: 0.000336639
Score: 0.232
Data Source: BioPlex,STRINGDB
SRFBP1
Tbio
Novelty: 0.10070972
p_int: 0.997214495
p_ni: 0.000200414
p_wrong: 0.002585091
Score: 0.261
Data Source: BioPlex,STRINGDB
PPP3R2
Tbio
Novelty: 0.01121867
p_int: 0.994882937
p_ni: 0.004575482
p_wrong: 0.000541581
Data Source: BioPlex
Publication Statistics
PubMed Score  8.83

PubMed score by year
PubTator Score  4.16

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer