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Tbio
UBE2E3
Ubiquitin-conjugating enzyme E2 E3

Protein Summary
Description
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-, as well as 'Lys-63'-linked polyubiquitination. Participates in the regulation of transepithelial sodium transport in renal cells. May be involved in cell growth arrest. The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein shares 100% sequence identity with the mouse and rat counterparts, which indicates that this enzyme is highly conserved in eukaryotes. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jun 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000392415
  • ENSP00000376215
  • ENSG00000170035
  • ENST00000410062
  • ENSP00000386788
  • ENST00000602710
  • ENSP00000473623
  • ENST00000602959
  • ENSP00000473639

Symbol
  • UBCE4
  • UBCH9
  • UBCH9
  • UbcM2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.98
kinase perturbation
0.91
transcription factor perturbation
0.91
molecular function
0.88
disease perturbation
0.74


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.48   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 547   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.48   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 547   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
4
5
5
98.5
lymphocyte percentage of leukocytes
2
2
2
92.4
neutrophil percentage of leukocytes
2
2
2
87.5
alkaline phosphatase measurement
2
2
1
6.6
78.7
2
2
0
1.1
78.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
5
98.5
lymphocyte percentage of leukocytes
2
92.4
neutrophil percentage of leukocytes
2
87.5
alkaline phosphatase measurement
1
6.6
78.7
0
1.1
78.2
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
ubiquitin conjugating enzyme E2 E3
704530
Mouse
MGI:107412
22193
Rat
RGD:1308894
295686
Dog
ubiquitin conjugating enzyme E2 E3
VGNC:53110
612823
Horse
ubiquitin conjugating enzyme E2 E3
VGNC:49291
100067766
Species
Name
OMA
EggNOG
Inparanoid
Macaque
ubiquitin conjugating enzyme E2 E3
Mouse
Rat
Dog
ubiquitin conjugating enzyme E2 E3
Horse
ubiquitin conjugating enzyme E2 E3
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q969T4-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (11)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Immune System
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Immune System
Metabolism of proteins
Protein-Protein Interactions (373)
1 – 10 of 373
RNF25
Tbio
Family:  Enzyme
Novelty:  0.08945219
p_int:  1
Score:  0.958
Data Source:  BioPlex,STRINGDB
RNF10
Tbio
Novelty:  0.09086567
p_int:  1
Score:  0.341
Data Source:  BioPlex,STRINGDB
PECR
Tbio
Family:  Enzyme
Novelty:  0.01550165
p_int:  0.999996006
p_ni:  0.000003978
p_wrong:  1.7e-8
Score:  0.184
Data Source:  BioPlex,STRINGDB
USP15
Tbio
Family:  Enzyme
Novelty:  0.0208842
p_int:  0.999982149
p_ni:  0.000017851
Score:  0.286
Data Source:  BioPlex,STRINGDB
UBB
Tbio
Novelty:  0.00661254
p_int:  0.999975722
p_ni:  0.000024278
Score:  0.946
Data Source:  BioPlex,STRINGDB
DET1
Tbio
Novelty:  0.01138079
p_int:  0.999880764
p_ni:  0.000119232
p_wrong:  5e-9
Score:  0.952
Data Source:  BioPlex,STRINGDB
OTUB1
Tbio
Family:  Enzyme
Novelty:  0.00536726
p_int:  0.99985218
p_ni:  0.00014782
Score:  0.567
Data Source:  BioPlex,STRINGDB
RNF220
Tbio
Family:  Enzyme
Novelty:  0.14024436
p_int:  0.999811258
p_ni:  0.000017048
p_wrong:  0.000171694
Score:  0.942
Data Source:  BioPlex,STRINGDB
TOPORS
Tbio
Family:  Enzyme
Novelty:  0.03910082
p_int:  0.999553497
p_ni:  0.000446502
Score:  0.191
Data Source:  BioPlex,STRINGDB
RCBTB2
Tbio
Novelty:  0.04244536
p_int:  0.996282228
p_ni:  0.003717772
p_wrong:  1e-9
Score:  0.508
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  22.48

PubMed score by year
PubTator Score  9.66

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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