Tbio UBE2E3 Ubiquitin-conjugating enzyme E2 E3

Protein Summary

Description

Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-, as well as 'Lys-63'-linked polyubiquitination. Participates in the regulation of transepithelial sodium transport in renal cells. May be involved in cell growth arrest. The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein shares 100% sequence identity with the mouse and rat counterparts, which indicates that this enzyme is highly conserved in eukaryotes. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jun 2013]

Uniprot Accession IDs

• Q969T4
• B2RAD6
• D3DPG3
• Q5U0R7
• Q7Z4W4

Gene Name

• UBE2E3

Ensembl ID

• ENST00000392415
• ENSP00000376215
• ENSG00000170035
• ENST00000410062
• ENSP00000386788
• ENST00000602710
• ENSP00000473623
• ENST00000602959
• ENSP00000473639

Symbol

• UBCE4
• UBCH9
• UBCH9
• UbcM2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.98
kinase perturbation	0.91
transcription factor perturbation	0.91
molecular function	0.88
disease perturbation	0.74

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.38   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 547   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.38   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 547   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0