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Tbio
GFM2
Ribosome-releasing factor 2, mitochondrial

Protein Summary
Description
Mitochondrial GTPase that mediates the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis. Acts in collaboration with MRRF. GTP hydrolysis follows the ribosome disassembly and probably occurs on the ribosome large subunit. Not involved in the GTP-dependent ribosomal translocation step during translation elongation. Eukaryotes contain two protein translational systems, one in the cytoplasm and one in the mitochondria. Mitochondrial translation is crucial for maintaining mitochondrial function and mutations in this system lead to a breakdown in the respiratory chain-oxidative phosphorylation system and to impaired maintenance of mitochondrial DNA. This gene encodes one of the mitochondrial translation elongation factors, which is a GTPase that plays a role at the termination of mitochondrial translation by mediating the disassembly of ribosomes from messenger RNA . Its role in the regulation of normal mitochondrial function and in disease ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000296805
  • ENSP00000296805
  • ENSG00000164347
  • ENST00000345239
  • ENSP00000296804
  • ENST00000427854
  • ENSP00000405808
  • ENST00000509430
  • ENSP00000427004

Symbol
  • EFG2
  • EFG2
  • RRF2
  • MRRF2
  • hEFG2
  • MST027
  • RRF2mt
  • EF-G2mt
  • MSTP027
  • mEF-G 2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
molecular function
0.96
transcription factor perturbation
0.91
transcription factor binding site profile
0.83
histone modification site profile
0.8


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.62   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 125   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.62   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 125   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0