Tclin HDAC10 Histone deacetylase 10

Protein Summary

Description

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. The protein encoded by this gene belongs to the histone deacetylase family, members of which deacetylate lysine residues on the N-terminal part of the core histones. Histone deacetylation modulates chromatin structure, and plays an important role in transcriptional regulation, cell cycle progression, and developmental events. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

Uniprot Accession IDs

• Q969S8
• Q08AP4
• Q6STF9
• Q96P77
• Q96P78
• Q9H028
• Q9UGX1
• Q9UGX2
• HD10

Gene Name

• HDAC10

Ensembl ID

• ENST00000216271
• ENSP00000216271
• ENSG00000100429
• ENST00000349505
• ENSP00000343540
• ENST00000454936
• ENSP00000406150

Symbol

• HD10

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.73
biological process	0.72
tissue sample	0.7
cellular component	0.61
histone modification site profile	0.59

Protein Classes

DTO Classes

Protein / Epigenetic Regulator / Eraser / Histone Deacetylase / Hdac Class Iib / Histone Deacetylase 10

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 118.35   (req: < 5)

Gene RIFs: 26   (req: <= 3)

Antibodies: 433   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 118.35   (req: >= 5)

Gene RIFs: 26   (req: > 3)

Antibodies: 433   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 234

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 5