Tclin HDAC10 Histone deacetylase 10

Protein Summary

Description

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. The protein encoded by this gene belongs to the histone deacetylase family, members of which deacetylate lysine residues on the N-terminal part of the core histones. Histone deacetylation modulates chromatin structure, and plays an important role in transcriptional regulation, cell cycle progression, and developmental events. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

Uniprot Accession IDs

• Q969S8
• Q08AP4
• Q6STF9
• Q96P77
• Q96P78
• Q9H028
• Q9UGX1
• Q9UGX2
• HD10

Gene Name

• HDAC10

Ensembl ID

• ENST00000216271
• ENSP00000216271
• ENSG00000100429
• ENST00000349505
• ENSP00000343540
• ENST00000454936
• ENSP00000406150

Symbol

• HD10

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.73
biological process	0.72
tissue sample	0.7
cellular component	0.61
histone modification site profile	0.59

Protein Classes

DTO Classes

Protein / Epigenetic Regulator / Eraser / Histone Deacetylase / Hdac Class Iib / Histone Deacetylase 10

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 103.89   (req: < 5)

Gene RIFs: 18   (req: <= 3)

Antibodies: 433   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 103.89   (req: >= 5)

Gene RIFs: 18   (req: > 3)

Antibodies: 433   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 223

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 5

Expression Data (0 Tissues)

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No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (5)

Explore Approved Drugs

1 – 5 of 5

vorinostat

HDAC10Tclin Epigenetic

INHIBITOR pKi : 9

romidepsin

HDAC10Tclin Epigenetic

INHIBITOR pKi : 5.96

belinostat

HDAC10Tclin Epigenetic

INHIBITOR pIC50 : 7.57

panobinostat

HDAC10Tclin Epigenetic

INHIBITOR pKi : 8.46

chidamide

HDAC10Tclin Epigenetic

INHIBITOR pIC50 : 7.11

Active Ligands (223)

Explore Active Ligands

1 – 10 of 223

fimepinostat

HDAC10Tclin Epigenetic

pIC50 : 9.44

trichostatin

HDAC10Tclin Epigenetic

pKi : 8.45

CUDC-101

HDAC10Tclin Epigenetic

pIC50 : 8.62

Belinosta

HDAC10Tclin Epigenetic

pKi : 7.66

CHEMBL1830424

HDAC10Tclin Epigenetic

pKi : 7.68

dacinostat

HDAC10Tclin Epigenetic

pKi : 8.85

KA1010

HDAC10Tclin Epigenetic

pIC50 : 8.1

pracinostat

HDAC10Tclin Epigenetic

pKi : 7.57

quisinostat

HDAC10Tclin Epigenetic

pKi : 7.51

scriptaid

HDAC10Tclin Epigenetic

pKi : 8.66

Protein-Protein Interactions (177)

Explore Interacting Targets

1 – 10 of 177

• See Interactions on String-DB

PCBP3

Tbio

Novelty:  0.11681812

p_int:  0.999645819

p_ni:  0.000354181

Score:  0.182

Data Source:  BioPlex,STRINGDB

LETMD1

Tbio

Novelty:  0.02790517

p_int:  0.992225999

p_ni:  0.007770412

p_wrong:  0.000003589

Score:  0.163

Data Source:  BioPlex,STRINGDB

NDUFB5

Tclin

Family:  Enzyme

Novelty:  0.0257403

p_int:  0.978905938

p_ni:  0.018679761

p_wrong:  0.002414301

Data Source:  BioPlex

UQCRH

Tbio

Novelty:  0.04494433

p_int:  0.975852749

p_ni:  0.007210073

p_wrong:  0.016937178

Data Source:  BioPlex

ZFPL1

Tbio

Novelty:  0.1829181

p_int:  0.915451686

p_ni:  0.079904877

p_wrong:  0.004643438

Score:  0.161

Data Source:  BioPlex,STRINGDB

GNPAT

Tchem

Family:  Enzyme

Novelty:  0.01255689

p_int:  0.90302598

p_ni:  0.09697402

Data Source:  BioPlex

EPHA4

Tchem

Family:  Kinase

Novelty:  0.00321698

p_int:  0.89942421

p_ni:  0.100575788

p_wrong:  2e-9

Score:  0.308

Data Source:  BioPlex,STRINGDB

SPG7

Tbio

Family:  Enzyme

Novelty:  0.00463357

p_int:  0.864235519

p_ni:  0.135762501

p_wrong:  0.00000198

Score:  0.195

Data Source:  BioPlex,STRINGDB

PI4K2B

Tbio

Family:  Enzyme

Novelty:  0.19272599

p_int:  0.846782908

p_ni:  0.153216637

p_wrong:  4.55e-7

Score:  0.191

Data Source:  BioPlex,STRINGDB

ABHD14A

Tdark

Family:  Enzyme

Novelty:  0.77988335

p_int:  0.812982647

p_ni:  0.186996996

p_wrong:  0.000020357

Score:  0.183

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (48)

Reactome (18)

KEGG (2)

PathwayCommons (2)

WikiPathways (26)

Chromatin modifying enzymes (R-HSA-3247509)

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5

1 – 5 of 18

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Chromatin modifying enzymes	238 targets	R-HSA-3247509
Reactome	Chromatin organization	238 targets	R-HSA-4839726
Reactome	Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	58 targets	R-HSA-2894862
Reactome	Constitutive Signaling by NOTCH1 PEST Domain Mutants	58 targets	R-HSA-2644606
Reactome	Disease	1105 targets	R-HSA-1643685

Name	Explore in Pharos	Explore in Source
Chromatin modifying enzymes	238 targets	R-HSA-3247509
Chromatin organization	238 targets	R-HSA-4839726
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	58 targets	R-HSA-2894862
Constitutive Signaling by NOTCH1 PEST Domain Mutants	58 targets	R-HSA-2644606
Disease	1105 targets	R-HSA-1643685

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (16)

Functions (5)

Components (4)

Processes (7)

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10

1 – 5 of 5

GO Term	Evidence	Assigned by
histone deacetylase activity	Inferred from Direct Assay (IDA)	UniProtKB
histone deacetylase binding	Inferred from Direct Assay (IDA)	UniProtKB
protein deacetylase activity	Inferred from Direct Assay (IDA)	UniProtKB
enzyme binding	Inferred from Physical Interaction (IPI)	UniProtKB
NAD-dependent histone deacetylase activity (H3-K14 specific)	Inferred from Electronic Annotation (IEA)	UniProtKB-EC

Disease Associations (null)

No disease associations found

GWAS Traits (21)

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5

1 – 5 of 21

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
platelet count	EFO_0004309	2	3	4		97.7
platelet crit	EFO_0007985	2	3	4		97.7
mitochondrial DNA measurement	EFO_0006312	1	2	2		76.1
eosinophil count	EFO_0004842	2	1	2		68.3
plasminogen activator inhibitor 1 measurement	EFO_0004792	1	1	0	421.8	61.4

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 21

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
platelet count	EFO_0004309	4		97.7
platelet crit	EFO_0007985	4		97.7
mitochondrial DNA measurement	EFO_0006312	2		76.1
eosinophil count	EFO_0004842	2		68.3
plasminogen activator inhibitor 1 measurement	EFO_0004792	0	421.8	61.4

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UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Chromatin regulator
Complete proteome
Cytoplasm
Hydrolase
Nucleus
Phosphoprotein
Polymorphism
Reference proteome
Repressor

GWAS Trait Find Similar Targets

No Header	No Header
bipolar disorder
body height
cutaneous melanoma
eosinophil count
eosinophil percentage of leukocytes
hair color
intelligence
liver fibrosis measurement
lymphocyte count
mathematical ability

MGI Phenotype Find Similar Targets

No Header	No Header
homeostasis/metabolism phenotype

IDG Resources

No IDG generated resources found

Orthologs (11)

1 – 5 of 11

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	histone deacetylase 10	VGNC:5267	458935
Macaque	histone deacetylase 10		715698
Mouse	histone deacetylase 10	MGI:2158340	170787
Rat	histone deacetylase 10	RGD:1305874	362981
Dog	histone deacetylase 10	VGNC:50626	607032

Species	Name	OMA	EggNOG	Inparanoid
Chimp	histone deacetylase 10
Macaque	histone deacetylase 10
Mouse	histone deacetylase 10
Rat	histone deacetylase 10
Dog	histone deacetylase 10

Publication Statistics

PubMed Score 103.89

PubMed score by year

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PubTator Score 36.52

PubTator score by year

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Related Publications

GeneRif Annotations (18)

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PMID	Text