Protein Summary
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. The protein encoded by this gene belongs to the histone deacetylase family, members of which deacetylate lysine residues on the N-terminal part of the core histones. Histone deacetylation modulates chromatin structure, and plays an important role in transcriptional regulation, cell cycle progression, and developmental events. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
- ENST00000216271
- ENSP00000216271
- ENSG00000100429
- ENST00000349505
- ENSP00000343540
- ENST00000454936
- ENSP00000406150
- HD10
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
molecular function | 0.73 | ||
biological process | 0.72 | ||
tissue sample | 0.7 | ||
cellular component | 0.61 | ||
histone modification site profile | 0.59 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 103.89 (req: < 5)
Gene RIFs: 18 (req: <= 3)
Antibodies: 433 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 103.89 (req: >= 5)
Gene RIFs: 18 (req: > 3)
Antibodies: 433 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 12
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 223
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 5
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (5)
Active Ligands (223)
Protein-Protein Interactions (177)
PCBP3
Novelty: 0.11681812
p_int: 0.999645819
p_ni: 0.000354181
Score: 0.182
Data Source: BioPlex,STRINGDB
LETMD1
Novelty: 0.02790517
p_int: 0.992225999
p_ni: 0.007770412
p_wrong: 0.000003589
Score: 0.163
Data Source: BioPlex,STRINGDB
NDUFB5
Family: Enzyme
Novelty: 0.0257403
p_int: 0.978905938
p_ni: 0.018679761
p_wrong: 0.002414301
Data Source: BioPlex
UQCRH
Novelty: 0.04494433
p_int: 0.975852749
p_ni: 0.007210073
p_wrong: 0.016937178
Data Source: BioPlex
ZFPL1
Novelty: 0.1829181
p_int: 0.915451686
p_ni: 0.079904877
p_wrong: 0.004643438
Score: 0.161
Data Source: BioPlex,STRINGDB
GNPAT
Family: Enzyme
Novelty: 0.01255689
p_int: 0.90302598
p_ni: 0.09697402
Data Source: BioPlex
EPHA4
Family: Kinase
Novelty: 0.00321698
p_int: 0.89942421
p_ni: 0.100575788
p_wrong: 2e-9
Score: 0.308
Data Source: BioPlex,STRINGDB
SPG7
Family: Enzyme
Novelty: 0.00463357
p_int: 0.864235519
p_ni: 0.135762501
p_wrong: 0.00000198
Score: 0.195
Data Source: BioPlex,STRINGDB
PI4K2B
Family: Enzyme
Novelty: 0.19272599
p_int: 0.846782908
p_ni: 0.153216637
p_wrong: 4.55e-7
Score: 0.191
Data Source: BioPlex,STRINGDB
ABHD14A
Family: Enzyme
Novelty: 0.77988335
p_int: 0.812982647
p_ni: 0.186996996
p_wrong: 0.000020357
Score: 0.183
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (48)
Reactome (18)
KEGG (2)
PathwayCommons (2)
WikiPathways (26)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Chromatin modifying enzymes | ||||
Reactome | Chromatin organization | ||||
Reactome | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | ||||
Reactome | Constitutive Signaling by NOTCH1 PEST Domain Mutants | ||||
Reactome | Disease | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Chromatin modifying enzymes | ||||
Chromatin organization | ||||
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | ||||
Constitutive Signaling by NOTCH1 PEST Domain Mutants | ||||
Disease | ||||
Viral Interactions (0)
Gene Ontology Terms (16)
Functions (5)
Components (4)
Processes (7)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-EC | |||
Disease Associations (null)
GWAS Traits (21)
Items per page:
1 – 5 of 21
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
platelet count | 2 | 3 | 4 | 97.7 | |||||
platelet crit | 2 | 3 | 4 | 97.7 | |||||
mitochondrial DNA measurement | 1 | 2 | 2 | 76.1 | |||||
eosinophil count | 2 | 1 | 2 | 68.3 | |||||
plasminogen activator inhibitor 1 measurement | 1 | 1 | 0 | 421.8 | 61.4 | ||||
Items per page:
1 – 5 of 21
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
platelet count | 4 | 97.7 | |||||
platelet crit | 4 | 97.7 | |||||
mitochondrial DNA measurement | 2 | 76.1 | |||||
eosinophil count | 2 | 68.3 | |||||
plasminogen activator inhibitor 1 measurement | 0 | 421.8 | 61.4 | ||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | histone deacetylase 10 | VGNC:5267 | 458935 | |||||
Macaque | histone deacetylase 10 | 715698 | ||||||
Mouse | MGI:2158340 | 170787 | ||||||
Rat | RGD:1305874 | 362981 | ||||||
Dog | histone deacetylase 10 | VGNC:50626 | 607032 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | histone deacetylase 10 | |||||
Macaque | histone deacetylase 10 | |||||
Mouse | ||||||
Rat | ||||||
Dog | histone deacetylase 10 | |||||
Publication Statistics
PubMed Score 103.89
PubMed score by year
PubTator Score 36.52
PubTator score by year
Related Publications
GeneRif Annotations (18)
Items per page:
0 of 0
PMID | Text |
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