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Tclin
HDAC10
Histone deacetylase 10

Protein Summary
Description
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. The protein encoded by this gene belongs to the histone deacetylase family, members of which deacetylate lysine residues on the N-terminal part of the core histones. Histone deacetylation modulates chromatin structure, and plays an important role in transcriptional regulation, cell cycle progression, and developmental events. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000216271
  • ENSP00000216271
  • ENSG00000100429
  • ENST00000349505
  • ENSP00000343540
  • ENST00000454936
  • ENSP00000406150

Symbol
  • HD10
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.73
biological process
0.72
tissue sample
0.7
cellular component
0.61
histone modification site profile
0.59


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 103.89   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 433   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 103.89   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 433   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 223
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 5
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (223)
1 – 10 of 223
fimepinostat
Rendered image for fimepinostat
trichostatin
Rendered image for trichostatin
CUDC-101
Rendered image for CUDC-101
Belinosta
Rendered image for Belinosta
CHEMBL1830424
Rendered image for CHEMBL1830424
dacinostat
Rendered image for dacinostat
KA1010
Rendered image for KA1010
pracinostat
Rendered image for pracinostat
quisinostat
Rendered image for quisinostat
scriptaid
Rendered image for scriptaid
Protein-Protein Interactions (177)
1 – 10 of 177
PCBP3
Tbio
Novelty:  0.11681812
p_int:  0.999645819
p_ni:  0.000354181
Score:  0.182
Data Source:  BioPlex,STRINGDB
LETMD1
Tbio
Novelty:  0.02790517
p_int:  0.992225999
p_ni:  0.007770412
p_wrong:  0.000003589
Score:  0.163
Data Source:  BioPlex,STRINGDB
NDUFB5
Tclin
Family:  Enzyme
Novelty:  0.0257403
p_int:  0.978905938
p_ni:  0.018679761
p_wrong:  0.002414301
Data Source:  BioPlex
UQCRH
Tbio
Novelty:  0.04494433
p_int:  0.975852749
p_ni:  0.007210073
p_wrong:  0.016937178
Data Source:  BioPlex
ZFPL1
Tbio
Novelty:  0.1829181
p_int:  0.915451686
p_ni:  0.079904877
p_wrong:  0.004643438
Score:  0.161
Data Source:  BioPlex,STRINGDB
GNPAT
Tchem
Family:  Enzyme
Novelty:  0.01255689
p_int:  0.90302598
p_ni:  0.09697402
Data Source:  BioPlex
EPHA4
Tchem
Family:  Kinase
Novelty:  0.00321698
p_int:  0.89942421
p_ni:  0.100575788
p_wrong:  2e-9
Score:  0.308
Data Source:  BioPlex,STRINGDB
SPG7
Tbio
Family:  Enzyme
Novelty:  0.00463357
p_int:  0.864235519
p_ni:  0.135762501
p_wrong:  0.00000198
Score:  0.195
Data Source:  BioPlex,STRINGDB
PI4K2B
Tbio
Family:  Enzyme
Novelty:  0.19272599
p_int:  0.846782908
p_ni:  0.153216637
p_wrong:  4.55e-7
Score:  0.191
Data Source:  BioPlex,STRINGDB
ABHD14A
Tdark
Family:  Enzyme
Novelty:  0.77988335
p_int:  0.812982647
p_ni:  0.186996996
p_wrong:  0.000020357
Score:  0.183
Data Source:  BioPlex,STRINGDB
Pathways (48)
Chromatin modifying enzymes (R-HSA-3247509)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 18
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Reactome
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Reactome
Disease
Name
Explore in Pharos
Explore in Source
Chromatin modifying enzymes
Chromatin organization
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Disease
Gene Ontology Terms (16)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
GWAS Traits (21)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
2
3
4
97.7
platelet crit
2
3
4
97.7
mitochondrial DNA measurement
1
2
2
76.1
eosinophil count
2
1
2
68.3
plasminogen activator inhibitor 1 measurement
1
1
0
421.8
61.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
4
97.7
platelet crit
4
97.7
mitochondrial DNA measurement
2
76.1
eosinophil count
2
68.3
plasminogen activator inhibitor 1 measurement
0
421.8
61.4
Find similar targets by:
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
histone deacetylase 10
VGNC:5267
458935
Macaque
histone deacetylase 10
715698
Mouse
MGI:2158340
170787
Rat
RGD:1305874
362981
Dog
histone deacetylase 10
VGNC:50626
607032
Species
Name
OMA
EggNOG
Inparanoid
Chimp
histone deacetylase 10
Macaque
histone deacetylase 10
Mouse
Rat
Dog
histone deacetylase 10
Publication Statistics
PubMed Score 103.89
PubMed score by year
PubTator Score 36.52
PubTator score by year