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Tdark
TMEM203
Transmembrane protein 203

Protein Summary
Description
Involved in the regulation of cellular calcium homeotasis (PubMed:25996873). Required for spermatogenesis (PubMed:25996873).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000343666
  • ENSP00000375053
  • ENSG00000187713

Symbol
  • HBEBP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.92
histone modification site profile
0.85
transcription factor binding site profile
0.67
tissue sample
0.63
cell type or tissue
0.54


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.98   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 1   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.98   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 1   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
3
3
4
89.1
creatinine measurement
1
2
2
86.1
reticulocyte measurement
3
1
3
82.3
reticulocyte count
6
1
6
80.4
serum urea measurement
1
1
1
54.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
4
89.1
creatinine measurement
2
86.1
reticulocyte measurement
3
82.3
reticulocyte count
6
80.4
serum urea measurement
1
54.4
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:2443597
227615
Rat
RGD:1306304
311800
Dog
transmembrane protein 203
VGNC:47522
491235
Cow
transmembrane protein 203
VGNC:36025
100299402
Opossum
transmembrane protein 203 [Source:HGNC Symbol;Acc:HGNC:28217]
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
transmembrane protein 203
Cow
transmembrane protein 203
Opossum
transmembrane protein 203 [Source:HGNC Symbol;Acc:HGNC:28217]
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q969S6-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Protein-Protein Interactions (24)
1 – 10 of 24
ILK
Tchem
Family:  Kinase
Novelty:  0.00147344
Score:  0.75
Data Source:  STRINGDB
TMEM60
Tdark
Novelty:  0.42676662
Score:  0.61
Data Source:  STRINGDB
NDOR1
Tbio
Family:  Enzyme
Novelty:  0.07400532
Score:  0.574
Data Source:  STRINGDB
TMEM185B
Tdark
Novelty:  0.90492561
Score:  0.571
Data Source:  STRINGDB
E4F1
Tbio
Family:  TF
Novelty:  0.02192338
Score:  0.564
Data Source:  STRINGDB
BMT2
Tbio
Family:  Enzyme
Novelty:  0.05916379
Score:  0.54
Data Source:  STRINGDB
TRMT5
Tbio
Family:  Enzyme
Novelty:  0.02509765
Score:  0.538
Data Source:  STRINGDB
SETD4
Tbio
Family:  Epigenetic
Novelty:  0.1994878
Score:  0.534
Data Source:  STRINGDB
CACNG5
Tdark
Family:  IC
Novelty:  0.52705448
Score:  0.528
Data Source:  STRINGDB
METAP1D
Tbio
Family:  Enzyme
Novelty:  0.17714714
Score:  0.522
Data Source:  STRINGDB
Publication Statistics
PubMed Score  2.98

PubMed score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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