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Tbio
SLC35B4
UDP-xylose and UDP-N-acetylglucosamine transporter

Protein Summary
Description
Sugar transporter that specifically mediates the transport of UDP-xylose (UDP-Xyl) and UDP-N-acetylglucosamine (UDP-GlcNAc) from cytosol into Golgi. Glycosyltransferases, such as SLC35B4, transport nucleotide sugars from the cytoplasm where they are synthesized, to the Golgi apparatus where they are utilized in the synthesis of glycoproteins, glycolipids, and proteoglycans (Ashikov et al., 2005 [PubMed 15911612]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000378509
  • ENSP00000367770
  • ENSG00000205060
  • ENST00000470969
  • ENSP00000485857

Symbol
  • YEA4
  • YEA
  • YEA4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.93
virus perturbation
0.85
histone modification site profile
0.83
microRNA
0.76
kinase perturbation
0.71


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.53   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 32   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.53   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 32   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
2
2
2
69.2
insomnia measurement
1
1
0
1
52.8
smoking status measurement
1
1
1
14.2
platelet crit
1
1
1
7.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
2
69.2
insomnia measurement
0
1
52.8
smoking status measurement
1
14.2
platelet crit
1
7.8
Pathways (4)
SLC-mediated transmembrane transport (R-HSA-425407)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
SLC-mediated transmembrane transport
Reactome
Transport of nucleotide sugars
Reactome
Transport of small molecules
Reactome
Transport of vitamins, nucleosides, and related molecules
Name
Explore in Pharos
Explore in Source
SLC-mediated transmembrane transport
Transport of nucleotide sugars
Transport of small molecules
Transport of vitamins, nucleosides, and related molecules
Gene Ontology Terms (14)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (41)
1 – 10 of 41
SLC35A3
Tbio
Family: Transporter
Novelty: 0.02472244
Score: 0.941
Data Source: STRINGDB
SLC35D2
Tbio
Family: Transporter
Novelty: 0.1135727
Score: 0.783
Data Source: STRINGDB
SLC35C2
Tdark
Family: Transporter
Novelty: 0.27116526
Score: 0.78
Data Source: STRINGDB
SLC35C1
Tbio
Family: Transporter
Novelty: 0.05958023
Score: 0.75
Data Source: STRINGDB
SLC25A10
Tbio
Family: Transporter
Novelty: 0.03534249
Score: 0.663
Data Source: STRINGDB
SLC35D1
Tbio
Family: Transporter
Novelty: 0.08762897
Score: 0.608
Data Source: STRINGDB
SLC35A1
Tbio
Family: Transporter
Novelty: 0.02071929
Score: 0.6
Data Source: STRINGDB
TBX4
Tbio
Family: TF
Novelty: 0.01370005
Score: 0.599
Data Source: STRINGDB
COASY
Tbio
Family: Enzyme
Novelty: 0.00294867
Score: 0.593
Data Source: STRINGDB
SLC35E1
Tdark
Family: Transporter
Novelty: 0.95475737
Score: 0.582
Data Source: STRINGDB
Publication Statistics
PubMed Score  15.53

PubMed score by year
PubTator Score  5.8

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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