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Tbio
SLC35B4
UDP-xylose and UDP-N-acetylglucosamine transporter

Protein Summary
Description
Sugar transporter that specifically mediates the transport of UDP-xylose (UDP-Xyl) and UDP-N-acetylglucosamine (UDP-GlcNAc) from cytosol into Golgi. Glycosyltransferases, such as SLC35B4, transport nucleotide sugars from the cytoplasm where they are synthesized, to the Golgi apparatus where they are utilized in the synthesis of glycoproteins, glycolipids, and proteoglycans (Ashikov et al., 2005 [PubMed 15911612]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000378509
  • ENSP00000367770
  • ENSG00000205060
  • ENST00000470969
  • ENSP00000485857

Symbol
  • YEA4
  • YEA
  • YEA4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.93
virus perturbation
0.85
histone modification site profile
0.83
microRNA
0.76
kinase perturbation
0.71


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.53   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 32   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.53   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 32   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (41)
SLC35A3
Tbio
Family:  Transporter
Novelty:  0.02472244
Score:  0.941
Data Source:  STRINGDB
SLC35D2
Tbio
Family:  Transporter
Novelty:  0.1135727
Score:  0.783
Data Source:  STRINGDB
SLC35C2
Tdark
Family:  Transporter
Novelty:  0.27116526
Score:  0.78
Data Source:  STRINGDB
SLC35C1
Tbio
Family:  Transporter
Novelty:  0.05958023
Score:  0.75
Data Source:  STRINGDB
SLC25A10
Tbio
Family:  Transporter
Novelty:  0.03534249
Score:  0.663
Data Source:  STRINGDB
SLC35D1
Tbio
Family:  Transporter
Novelty:  0.08762897
Score:  0.608
Data Source:  STRINGDB
SLC35A1
Tbio
Family:  Transporter
Novelty:  0.02071929
Score:  0.6
Data Source:  STRINGDB
TBX4
Tbio
Family:  TF
Novelty:  0.01370005
Score:  0.599
Data Source:  STRINGDB
COASY
Tbio
Family:  Enzyme
Novelty:  0.00294867
Score:  0.593
Data Source:  STRINGDB
SLC35E1
Tdark
Family:  Transporter
Novelty:  0.95475737
Score:  0.582
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
SLC-mediated transmembrane transport (R-HSA-425407)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
SLC-mediated transmembrane transport
Reactome
Transport of nucleotide sugars
Reactome
Transport of small molecules
Reactome
Transport of vitamins, nucleosides, and related molecules
Name
Explore in Pharos
Explore in Source
SLC-mediated transmembrane transport
Transport of nucleotide sugars
Transport of small molecules
Transport of vitamins, nucleosides, and related molecules
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (14)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
2
2
2
91.2
insomnia measurement
1
1
0
1
33.1
platelet crit
1
1
1
29
smoking status measurement
1
1
1
6.2
systolic blood pressure change measurement
1
1
0
19.1
0
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
2
91.2
insomnia measurement
0
1
33.1
platelet crit
1
29
smoking status measurement
1
6.2
systolic blood pressure change measurement
0
19.1
0
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 35 member B4
VGNC:14088
463743
Macaque
solute carrier family 35 member B4
705822
Mouse
MGI:1931249
58246
Rat
RGD:1308985
296969
Dog
solute carrier family 35 member B4
VGNC:46367
482249
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 35 member B4
Macaque
solute carrier family 35 member B4
Mouse
Rat
Dog
solute carrier family 35 member B4
Publication Statistics
PubMed Score 15.53
PubMed score by year
PubTator Score 5.80
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title