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Tbio
ITFG2
KICSTOR complex protein ITFG2

Protein Summary
Description
As part of the KICSTOR complex functions in the amino acid-sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the RAG GTPases. Functions upstream of the RAG GTPases and is required to negatively regulate mTORC1 signaling in absence of amino acids. In absence of the KICSTOR complex mTORC1 is constitutively localized to the lysosome and activated. The KICSTOR complex is also probably involved in the regulation of mTORC1 by glucose.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000228799
  • ENSP00000228799
  • ENSG00000111203
  • ENST00000540929
  • ENSP00000443329
  • ENST00000644517
  • ENSP00000496068

Symbol
  • FGGAP1
  • MDS028
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.92
cell type or tissue
0.76
histone modification site profile
0.67
phenotype
0.63
virus perturbation
0.59


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.19   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 215   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.19   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 215   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Gene Ontology Terms (8)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (42)
1 – 10 of 42
KPTN
Tbio
Novelty: 0.03538431
p_int: 1
Score: 0.994
Data Source: BioPlex,Reactome,STRINGDB
C12orf66
Tbio
Novelty: 4.5
p_int: 0.999999963
p_ni: 3.7e-8
Score: 0.995
Data Source: BioPlex,Reactome,STRINGDB
SZT2
Tbio
Novelty: 0.10810811
p_int: 0.999999629
p_ni: 3.71e-7
Score: 0.995
Data Source: BioPlex,Reactome,STRINGDB
SH3PXD2B
Tbio
Novelty: 0.01887611
p_int: 0.999998504
p_ni: 0.000001496
Score: 0.204
Data Source: BioPlex,STRINGDB
VWCE
Tbio
Novelty: 0.10129635
p_int: 0.999996635
p_ni: 0.000003365
Data Source: BioPlex
OTUD3
Tbio
Novelty: 0.21352313
p_int: 0.999978319
p_ni: 0.000021681
Data Source: BioPlex
PROSER2
Tdark
Novelty: 2.22222222
p_int: 0.99995292
p_ni: 0.00004708
Data Source: BioPlex
BMT2
Tbio
Family: Enzyme
Novelty: 0.07430189
p_int: 0.999949759
p_ni: 0.000050241
Score: 0.681
Data Source: BioPlex,Reactome,STRINGDB
INPP5A
Tchem
Family: Enzyme
Novelty: 0.03832271
p_int: 0.999114421
p_ni: 0.000885579
Score: 0.234
Data Source: BioPlex,STRINGDB
C1QTNF2
Tdark
Novelty: 0.37393768
p_int: 0.996593523
p_ni: 0.003406477
Score: 0.219
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  1.19

PubMed score by year
PubTator Score  1.2

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer