Tbio L3MBTL2 Lethal(3)malignant brain tumor-like protein 2

Protein Summary

Description

Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility. Its association with a chromatin-remodeling complex suggests that it may contribute to prevent expression of genes that trigger the cell into mitosis. Binds to monomethylated and dimethylated 'Lys-20' on histone H4. Binds histone H3 peptides that are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'.

Uniprot Accession IDs

• Q969R5
• Q8TEN1
• Q96SC4
• Q9BQI2
• Q9UGS4
• H-l(3)mbt-like protein 2

Gene Name

• L3MBTL2

Ensembl ID

• ENST00000216237
• ENSP00000216237
• ENSG00000100395
• ENST00000452106
• ENSP00000414423

Symbol

• L3MBT
• H-l(3)mbt-l

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor binding site profile	0.71
histone modification site profile	0.69
tissue sample	0.68
transcription factor	0.59
tissue	0.56

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.95   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 194   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.95   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 194   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

Show Full Sequence

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Related Tools

Target Illumination GWAS Analytics (TIGA)

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Protein-Protein Interactions (96)

Explore Interacting Targets

1 – 10 of 96

• See Interactions on String-DB

PCGF6

Tbio

Novelty:  0.07032909

p_int:  1

Score:  0.99

Data Source:  BioPlex,Reactome,STRINGDB

E2F6

Tbio

Family:  TF

Novelty:  0.00753541

p_int:  0.999999999

p_ni:  1e-9

Score:  0.993

Data Source:  BioPlex,Reactome,STRINGDB

RYBP

Tbio

Novelty:  0.01140945

p_int:  0.999999909

p_ni:  9.1e-8

Score:  0.91

Data Source:  BioPlex,Reactome,STRINGDB

HDAC1

Tclin

Family:  Epigenetic

Novelty:  0.00065244

p_int:  0.999999635

p_ni:  3.65e-7

Score:  0.495

Data Source:  BioPlex,STRINGDB

ITPRID2

Tbio

Novelty:  0.07923791

p_int:  0.999999439

p_ni:  5.61e-7

Data Source:  BioPlex

SERPINF1

Tbio

Novelty:  0.00555849

p_int:  0.999999328

p_ni:  6.72e-7

Score:  0.163

Data Source:  BioPlex,STRINGDB

TFDP1

Tbio

Family:  TF

Novelty:  0.02026858

p_int:  0.99999908

p_ni:  9.01e-7

p_wrong:  2e-8

Score:  0.982

Data Source:  BioPlex,Reactome,STRINGDB

TFDP2

Tbio

Family:  TF

Novelty:  0.14331363

p_int:  0.999998891

p_ni:  4.28e-7

p_wrong:  6.81e-7

Data Source:  BioPlex

CIZ1

Tbio

Novelty:  0.03730538

p_int:  0.99999883

p_ni:  0.00000117

Data Source:  BioPlex

MGA

Tbio

Family:  TF

Novelty:  0.08965274

p_int:  0.999996757

p_ni:  0.000003243

Score:  0.973

Data Source:  BioPlex,Reactome,STRINGDB

Pathways (9)

Reactome (9)

Gene expression (Transcription) (R-HSA-74160)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Gene expression (Transcription)	1452 targets	R-HSA-74160
Reactome	Generic Transcription Pathway	1195 targets	R-HSA-212436
Reactome	Metabolism of proteins	2050 targets	R-HSA-392499
Reactome	Post-translational protein modification	1450 targets	R-HSA-597592
Reactome	RNA Polymerase II Transcription	1314 targets	R-HSA-73857

Name	Explore in Pharos	Explore in Source
Gene expression (Transcription)	1452 targets	R-HSA-74160
Generic Transcription Pathway	1195 targets	R-HSA-212436
Metabolism of proteins	2050 targets	R-HSA-392499
Post-translational protein modification	1450 targets	R-HSA-597592
RNA Polymerase II Transcription	1314 targets	R-HSA-73857

Gene Ontology Terms (8)

Functions (3)

Components (2)

Processes (3)

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1 – 3 of 3

GO Term	Evidence	Assigned by
methylated histone binding	Inferred from Direct Assay (IDA)	UniProtKB
histone binding	Inferred from Physical Interaction (IPI)	UniProtKB
zinc ion binding	Inferred from Electronic Annotation (IEA)	InterPro

GWAS Traits (34)

• Explore on Target Illumination GWAS Analytics (TIGA)

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1 – 5 of 34

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
unipolar depression	EFO_0003761	4	3	2	1	94.8
neuroticism measurement	EFO_0007660	6	6	4	7	89.4
osteoarthritis, hip	EFO_1000786	1	2	0	5.9	88.5
risk-taking behaviour	EFO_0008579	2	4	4		84.3
red blood cell distribution width	EFO_0005192	2	2	2		83.6

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1 – 5 of 34

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
unipolar depression	EFO_0003761	2	1	94.8
neuroticism measurement	EFO_0007660	4	7	89.4
osteoarthritis, hip	EFO_1000786	0	5.9	88.5
risk-taking behaviour	EFO_0008579	4		84.3
red blood cell distribution width	EFO_0005192	2		83.6

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Alternative splicing
Chromatin regulator
Complete proteome
Isopeptide bond
Metal-binding
Nucleus
Phosphoprotein
Polymorphism
Reference proteome

GWAS Trait Find Similar Targets

No Header	No Header
anxiety measurement
appendicular lean mass
autism spectrum disorder
bipolar disorder
bitter beverage consumption measurement
BMI-adjusted waist-hip ratio
coffee consumption measurement
cognitive function measurement
depressive symptom measurement
eosinophil percentage of granulocytes

MGI Phenotype Find Similar Targets

No Header	No Header
embryo phenotype
growth/size/body region phenotype
hematopoietic system phenotype
immune system phenotype
mortality/aging
skeleton phenotype

Orthologs (13)

1 – 5 of 13

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	L3MBTL2, polycomb repressive complex 1 subunit	VGNC:10088	458863
Macaque	L3MBTL2, polycomb repressive complex 1 subunit		706602
Mouse	L3MBTL2 polycomb repressive complex 1 subunit	MGI:2443584	214669
Rat	L3MBTL2 polycomb repressive complex 1 subunit	RGD:1308569	300320
Dog	L3MBTL2, polycomb repressive complex 1 subunit	VGNC:42558	481235

Species	Name	OMA	EggNOG	Inparanoid
Chimp	L3MBTL2, polycomb repressive complex 1 subunit
Macaque	L3MBTL2, polycomb repressive complex 1 subunit
Mouse	L3MBTL2 polycomb repressive complex 1 subunit
Rat	L3MBTL2 polycomb repressive complex 1 subunit
Dog	L3MBTL2, polycomb repressive complex 1 subunit

Publication Statistics

PubMed Score 11.95

PubMed score by year

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PubTator Score 7.14

PubTator score by year

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