Tbio L3MBTL2 Lethal(3)malignant brain tumor-like protein 2

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Lethal(3)malignant Brain Tumor-like Protein 2

Protein / Nucleic Acid Binding / Dna Binding Protein / Chromatin/chromatin-binding Protein / Lethal(3)malignant Brain Tumor-like Protein 2

DTO Classes

Protein / Nucleic Acid Binding / Dna Binding Protein / Chromatin/chromatin-binding Protein / Lethal(3)malignant Brain Tumor-like Protein 2

Protein Summary

Description

Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility. Its association with a chromatin-remodeling complex suggests that it may contribute to prevent expression of genes that trigger the cell into mitosis. Binds to monomethylated and dimethylated 'Lys-20' on histone H4. Binds histone H3 peptides that are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'.

Uniprot Accession IDs

• Q969R5
• Q8TEN1
• Q96SC4
• Q9BQI2
• Q9UGS4
• H-l(3)mbt-like protein 2

Gene Name

• L3MBTL2

Ensembl ID

• ENST00000216237
• ENSP00000216237
• ENSG00000100395
• ENST00000452106
• ENSP00000414423

Symbol

• L3MBT
• H-l(3)mbt-l

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor binding site profile	0.71
histone modification site profile	0.69
tissue sample	0.68
transcription factor	0.59
tissue	0.56

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.85   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 194   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.85   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 194   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

GWAS Traits (7)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 7

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
neuroticism measurement	EFO_0007660	4	3	3	8.8	97.5
depressive symptom measurement	EFO_0007006	3	2	3		93.5
unipolar depression	EFO_0003761	3	2	1	1	90
wellbeing measurement	EFO_0007869	2	1	2		87.3
bipolar disorder	EFO_0000289	1	1	0	1	84.1

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 7

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
neuroticism measurement	EFO_0007660	3	8.8	97.5
depressive symptom measurement	EFO_0007006	3		93.5
unipolar depression	EFO_0003761	1	1	90
wellbeing measurement	EFO_0007869	2		87.3
bipolar disorder	EFO_0000289	0	1	84.1

Reset Zoom  Beta Count   Odds Ratio

Orthologs (13)

1 – 5 of 13

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	L3MBTL2, polycomb repressive complex 1 subunit	VGNC:10088	458863
Macaque	L3MBTL2, polycomb repressive complex 1 subunit		706602
Mouse	L3MBTL2 polycomb repressive complex 1 subunit	MGI:2443584	214669
Rat	L3MBTL2 polycomb repressive complex 1 subunit	RGD:1308569	300320
Dog	L3MBTL2, polycomb repressive complex 1 subunit	VGNC:42558	481235

Species	Name	OMA	EggNOG	Inparanoid
Chimp	L3MBTL2, polycomb repressive complex 1 subunit
Macaque	L3MBTL2, polycomb repressive complex 1 subunit
Mouse	L3MBTL2 polycomb repressive complex 1 subunit
Rat	L3MBTL2 polycomb repressive complex 1 subunit
Dog	L3MBTL2, polycomb repressive complex 1 subunit

Protein Structure (3 Structures, 1 AlphaFold Model)

Representation

  axes   backbone   ball+stick   cartoon   rocket   rope   spacefill

Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q969R5-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3

PDB Structure Id	Ligand	Method	Resolution (Å)	Residues	Fraction of Total Protein	Pub Year	Title

PDB Structure Id	Fraction of Total Protein	Resolution	Pub Year

Pathways (9)

Reactome (9)

Gene expression (Transcription) (R-HSA-74160)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Gene expression (Transcription)	1452 targets	R-HSA-74160
Reactome	Generic Transcription Pathway	1195 targets	R-HSA-212436
Reactome	Metabolism of proteins	2050 targets	R-HSA-392499
Reactome	Post-translational protein modification	1450 targets	R-HSA-597592
Reactome	RNA Polymerase II Transcription	1314 targets	R-HSA-73857

Name	Explore in Pharos	Explore in Source
Gene expression (Transcription)	1452 targets	R-HSA-74160
Generic Transcription Pathway	1195 targets	R-HSA-212436
Metabolism of proteins	2050 targets	R-HSA-392499
Post-translational protein modification	1450 targets	R-HSA-597592
RNA Polymerase II Transcription	1314 targets	R-HSA-73857

Gene Ontology Terms (8)

Functions (3)

Components (2)

Processes (3)

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Items per page:

10

1 – 3 of 3

GO Term	Evidence	Assigned by
methylated histone binding	Inferred from Direct Assay (IDA)	UniProtKB
histone binding	Inferred from Physical Interaction (IPI)	UniProtKB
zinc ion binding	Inferred from Electronic Annotation (IEA)	InterPro

Protein-Protein Interactions (96)

Explore Interacting Targets

1 – 10 of 96

• See Interactions on String-DB

PCGF6

Tbio

Novelty: 0.07032909

p_int: 1

Score: 0.99

Data Source: BioPlex,Reactome,STRINGDB

E2F6

Tbio

Family: TF

Novelty: 0.00753541

p_int: 0.999999999

p_ni: 1e-9

Score: 0.993

Data Source: BioPlex,Reactome,STRINGDB

RYBP

Tbio

Novelty: 0.01140945

p_int: 0.999999909

p_ni: 9.1e-8

Score: 0.91

Data Source: BioPlex,Reactome,STRINGDB

HDAC1

Tclin

Family: Epigenetic

Novelty: 0.00065244

p_int: 0.999999635

p_ni: 3.65e-7

Score: 0.495

Data Source: BioPlex,STRINGDB

ITPRID2

Tbio

Novelty: 0.07923791

p_int: 0.999999439

p_ni: 5.61e-7

Data Source: BioPlex

SERPINF1

Tbio

Novelty: 0.00555849

p_int: 0.999999328

p_ni: 6.72e-7

Score: 0.163

Data Source: BioPlex,STRINGDB

TFDP1

Tbio

Family: TF

Novelty: 0.02026858

p_int: 0.99999908

p_ni: 9.01e-7

p_wrong: 2e-8

Score: 0.982

Data Source: BioPlex,Reactome,STRINGDB

TFDP2

Tbio

Family: TF

Novelty: 0.14331363

p_int: 0.999998891

p_ni: 4.28e-7

p_wrong: 6.81e-7

Data Source: BioPlex

CIZ1

Tbio

Novelty: 0.03730538

p_int: 0.99999883

p_ni: 0.00000117

Data Source: BioPlex

MGA

Tbio

Family: TF

Novelty: 0.08965274

p_int: 0.999996757

p_ni: 0.000003243

Score: 0.973

Data Source: BioPlex,Reactome,STRINGDB

Publication Statistics

PubMed Score  10.85

PubMed score by year

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PubTator Score  7.14

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

Show Full Sequence

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UniProt Keyword Find Similar Targets

3D-structure
Alternative splicing
Chromatin regulator
Complete proteome
Isopeptide bond
Metal-binding
Nucleus
Phosphoprotein
Polymorphism
Reference proteome

GWAS Trait Find Similar Targets

bipolar disorder
depressive symptom measurement
mood instability measurement
neuroticism measurement
red blood cell distribution width
unipolar depression
wellbeing measurement

MGI Phenotype Find Similar Targets

embryo phenotype
growth/size/body region phenotype
hematopoietic system phenotype
immune system phenotype
mortality/aging
skeleton phenotype