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Tbio
L3MBTL2
Lethal(3)malignant brain tumor-like protein 2

Protein Summary
Description
Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility. Its association with a chromatin-remodeling complex suggests that it may contribute to prevent expression of genes that trigger the cell into mitosis. Binds to monomethylated and dimethylated 'Lys-20' on histone H4. Binds histone H3 peptides that are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000216237
  • ENSP00000216237
  • ENSG00000100395
  • ENST00000452106
  • ENSP00000414423

Symbol
  • L3MBT
  • H-l(3)mbt-l
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.71
histone modification site profile
0.69
tissue sample
0.68
transcription factor
0.59
tissue
0.56


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.85   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 194   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.85   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 194   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neuroticism measurement
4
3
3
8.8
97.5
depressive symptom measurement
3
2
3
93.5
unipolar depression
3
2
1
1
90
wellbeing measurement
2
1
2
87.3
1
1
0
1
84.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neuroticism measurement
3
8.8
97.5
depressive symptom measurement
3
93.5
unipolar depression
1
1
90
wellbeing measurement
2
87.3
0
1
84.1
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
L3MBTL2, polycomb repressive complex 1 subunit
VGNC:10088
458863
Macaque
L3MBTL2, polycomb repressive complex 1 subunit
706602
Mouse
MGI:2443584
214669
Rat
RGD:1308569
300320
Dog
L3MBTL2, polycomb repressive complex 1 subunit
VGNC:42558
481235
Species
Name
OMA
EggNOG
Inparanoid
Chimp
L3MBTL2, polycomb repressive complex 1 subunit
Macaque
L3MBTL2, polycomb repressive complex 1 subunit
Mouse
Rat
Dog
L3MBTL2, polycomb repressive complex 1 subunit
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q969R5-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (9)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
RNA Polymerase II Transcription
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
Metabolism of proteins
Post-translational protein modification
RNA Polymerase II Transcription
Gene Ontology Terms (8)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (96)
1 – 10 of 96
PCGF6
Tbio
Novelty: 0.07032909
p_int: 1
Score: 0.99
Data Source: BioPlex,Reactome,STRINGDB
E2F6
Tbio
Family: TF
Novelty: 0.00753541
p_int: 0.999999999
p_ni: 1e-9
Score: 0.993
Data Source: BioPlex,Reactome,STRINGDB
RYBP
Tbio
Novelty: 0.01140945
p_int: 0.999999909
p_ni: 9.1e-8
Score: 0.91
Data Source: BioPlex,Reactome,STRINGDB
HDAC1
Tclin
Family: Epigenetic
Novelty: 0.00065244
p_int: 0.999999635
p_ni: 3.65e-7
Score: 0.495
Data Source: BioPlex,STRINGDB
ITPRID2
Tbio
Novelty: 0.07923791
p_int: 0.999999439
p_ni: 5.61e-7
Data Source: BioPlex
SERPINF1
Tbio
Novelty: 0.00555849
p_int: 0.999999328
p_ni: 6.72e-7
Score: 0.163
Data Source: BioPlex,STRINGDB
TFDP1
Tbio
Family: TF
Novelty: 0.02026858
p_int: 0.99999908
p_ni: 9.01e-7
p_wrong: 2e-8
Score: 0.982
Data Source: BioPlex,Reactome,STRINGDB
TFDP2
Tbio
Family: TF
Novelty: 0.14331363
p_int: 0.999998891
p_ni: 4.28e-7
p_wrong: 6.81e-7
Data Source: BioPlex
CIZ1
Tbio
Novelty: 0.03730538
p_int: 0.99999883
p_ni: 0.00000117
Data Source: BioPlex
MGA
Tbio
Family: TF
Novelty: 0.08965274
p_int: 0.999996757
p_ni: 0.000003243
Score: 0.973
Data Source: BioPlex,Reactome,STRINGDB
Publication Statistics
PubMed Score  10.85

PubMed score by year
PubTator Score  7.14

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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