Tbio OSBP2 Oxysterol-binding protein 2

Protein Summary

Description

Binds 7-ketocholesterol. The protein encoded by this gene contains a pleckstrin homology (PH) domain and an oxysterol-binding region. It binds oxysterols such as 7-ketocholesterol and may inhibit their cytotoxicity. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2013]

Uniprot Accession IDs

• Q969R2
• B0QYG1
• B4DK24
• B4DKE4
• B4DTR3
• F5H2A3
• O60396
• Q0VF99
• Q8NA37
• Q9BY96
• Q9BZF0

Gene Name

• OSBP2

Ensembl ID

• ENST00000332585
• ENSP00000332576
• ENSG00000184792
• ENST00000401475
• ENSP00000385254
• ENST00000437268
• ENSP00000389200
• ENST00000438716
• ENSP00000411052
• ENST00000446658
• ENSP00000392080
• ENST00000535268
• ENSP00000438713

Symbol

• KIAA1664
• ORP4
• OSBPL4
• HLM
• ORP4
• ORP-4
• OSBPL1
• OSBPL4

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.82
tissue	0.68
microRNA	0.62
cell line	0.61
phenotype	0.58

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.37   (req: < 5)

Gene RIFs: 17   (req: <= 3)

Antibodies: 107   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.37   (req: >= 5)

Gene RIFs: 17   (req: > 3)

Antibodies: 107   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0