Tbio PPP2R3C Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma

Protein Summary

Description

May regulate MCM3AP phosphorylation through phosphatase recruitment. May act as a negative regulator of ABCB1 expression and function through the dephosphorylation of ABCB1 by TFPI2/PPP2R3C complex. May play a role in the activation-induced cell death of B-cells. This gene encodes a regulatory subunit of the serine/threonine phosphatase, protein phosphatase 2. This protein is localized to both nuclear and cytoplasmic regions depending on cell cycle phase. Homozygous conditional knockout mice for this gene exhibit reduced numbers and impaired proliferation of immune system B cells. This protein may regulate the expression of the P-glycoprotein ATP-binding cassette transporter through its phosphatase activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]

Uniprot Accession IDs

• Q969Q6
• B4DEN7
• D3DS97
• D3DS98
• Q5GJ55
• Q5GJ56
• Q6P4G2
• Q86TZ3
• Q9NWR9

Gene Name

• PPP2R3C

Ensembl ID

• ENST00000261475
• ENSP00000261475
• ENSG00000092020

Symbol

• C14orf10
• G5PR
• G4-1
• G5pr
• C14orf10

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.91
transcription factor binding site profile	0.87
transcription factor perturbation	0.8
biological process	0.72
kinase perturbation	0.71

Protein Classes

PANTHER Classes

Protein / Hydrolase / Phosphatase / Serine/threonine-protein Phosphatase 2a Regulatory Subunit B'' Subunit Gamma

DTO Classes

Protein / Enzyme / Hydrolase / Phosphatase / Serine/threonine-protein Phosphatase 2a Regulatory Subunit B'' Subunit Gamma

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 50.88   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 151   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 50.88   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 151   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0