You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
TRIM63
E3 ubiquitin-protein ligase TRIM63

Protein Summary
Description
E3 ubiquitin ligase. Mediates the ubiquitination and subsequent proteasomal degradation of CKM, GMEB1 and HIBADH. Regulates the proteasomal degradation of muscle proteins under amino acid starvation, where muscle protein is catabolized to provide other organs with amino acids. Inhibits de novo skeletal muscle protein synthesis under amino acid starvation. Regulates proteasomal degradation of cardiac troponin I/TNNI3 and probably of other sarcomeric-associated proteins. May play a role in striated muscle atrophy and hypertrophy by regulating an anti-hypertrophic PKC-mediated signaling pathway. May regulate the organization of myofibrils through TTN in muscle cells. This gene encodes a member of the RING zinc finger protein family found in striated muscle and iris. The product of this gene is an E3 ubiquitin ligase that localizes to the Z-line and M-line lattices of myofibrils. This protein plays an important role in the atrophy of skeletal and cardiac muscle and is required for the degr ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000374272
  • ENSP00000363390
  • ENSG00000158022

Symbol
  • IRF
  • MURF1
  • RNF28
  • SMRZ
  • IRF
  • SMRZ
  • MURF1
  • MURF2
  • RNF28
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.76
cell type or tissue
0.73
protein domain
0.73
cellular component
0.67
biological process
0.62


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 265.31   (req: < 5)
Gene RIFs: 41   (req: <= 3)
Antibodies: 320   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 265.31   (req: >= 5)
Gene RIFs: 41   (req: > 3)
Antibodies: 320   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
1
2
65.5
electrocardiography
1
1
9
62.1
IGF-1 measurement
1
1
1
27.2
BMI-adjusted hip circumference
1
1
1
21.5
1
1
1
8.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
65.5
electrocardiography
9
62.1
IGF-1 measurement
1
27.2
BMI-adjusted hip circumference
1
21.5
1
8.9
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tripartite motif containing 63
VGNC:8557
469240
Macaque
tripartite motif containing 63
713802
Mouse
MGI:2447992
433766
Rat
RGD:619964
140939
Dog
tripartite motif containing 63
VGNC:47831
487362
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tripartite motif containing 63
Macaque
tripartite motif containing 63
Mouse
Rat
Dog
tripartite motif containing 63
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q969Q1-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (12)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
FOXO-mediated transcription
Reactome
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
FOXO-mediated transcription
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
Gene Ontology Terms (15)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (380)
1 – 10 of 380
FBXO32
Tbio
Novelty:  0.00225437
Score:  0.992
Data Source:  STRINGDB
UBE2K
Tbio
Novelty:  0.00214955
Score:  0.955
Data Source:  STRINGDB
UBE2D1
Tbio
Novelty:  0.00865867
Score:  0.953
Data Source:  STRINGDB
UBE2D2
Tbio
Novelty:  0.00603877
Score:  0.952
Data Source:  STRINGDB
UBE2D3
Tchem
Novelty:  0.01908446
Score:  0.952
Data Source:  STRINGDB
UBE2S
Tbio
Novelty:  0.00363304
Score:  0.948
Data Source:  STRINGDB
TRIM32
Tbio
Family:  Enzyme
Novelty:  0.00103526
Score:  0.944
Data Source:  STRINGDB
UBE2N
Tchem
Novelty:  0.00620946
Score:  0.942
Data Source:  STRINGDB
FBXO40
Tbio
Novelty:  0.20308726
Score:  0.94
Data Source:  STRINGDB
NEDD4
Tchem
Family:  Enzyme
Novelty:  0.00281725
Score:  0.94
Data Source:  STRINGDB
Publication Statistics
PubMed Score  265.31

PubMed score by year
PubTator Score  356.33

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: