You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
TAAR8
Trace amine-associated receptor 8

Protein Summary
Description
Orphan receptor. Could be a receptor for trace amines. Trace amines are biogenic amines present in very low levels in mammalian tissues. Although some trace amines have clearly defined roles as neurotransmitters in invertebrates, the extent to which they function as true neurotransmitters in vertebrates has remained speculative. Trace amines are likely to be involved in a variety of physiological functions that have yet to be fully understood. This gene is part of the trace amine receptor cluster on chromosome 6 and encodes an orphan G-protein coupled receptor. Upregulated expression of this gene in astroglial cells upon exposure to lipopolysaccharides suggests a function for the encoded protein in the brain. [provided by RefSeq, Jul 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000275200
  • ENSP00000275200
  • ENSG00000146385

Symbol
  • GPR102
  • TA5
  • TAR5
  • TRAR5
  • TA5
  • TAR5
  • TRAR5
  • TaR-5
  • TaR-8
  • GPR102
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell line
0.64
cell type or tissue
0.62
biological process
0.49
PubMedID
0.42
protein domain
0.41


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 107.59   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 118   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 107.59   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 118   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (8)
Amine ligand-binding receptors (R-HSA-375280)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amine ligand-binding receptors
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (s) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Name
Explore in Pharos
Explore in Source
Amine ligand-binding receptors
Class A/1 (Rhodopsin-like receptors)
G alpha (s) signalling events
GPCR downstream signalling
GPCR ligand binding
Protein-Protein Interactions (130)
1 – 10 of 130
TAAR6
Tbio
Family: GPCR
Novelty: 0.00594707
Score: 0.919
Data Source: STRINGDB
TAAR2
Tbio
Family: GPCR
Novelty: 0.03271874
Score: 0.919
Data Source: STRINGDB
SCT
Tbio
Novelty: 0.00070278
Score: 0.917
Data Source: STRINGDB
GNG7
Tbio
Novelty: 0.08478455
Score: 0.916
Data Source: STRINGDB
GNB5
Tbio
Novelty: 0.0067714
Score: 0.915
Data Source: STRINGDB
GNB1
Tbio
Novelty: 0.02477955
Score: 0.915
Data Source: STRINGDB
GNB3
Tbio
Novelty: 0.0037117
Score: 0.915
Data Source: STRINGDB
GNB2
Tbio
Novelty: 0.08682553
Score: 0.915
Data Source: STRINGDB
GNB4
Tbio
Novelty: 0.08250797
Score: 0.915
Data Source: STRINGDB
GNAS
Tbio
Novelty: 0.00284739
Score: 0.914
Data Source: STRINGDB
Publication Statistics
PubMed Score  107.59

PubMed score by year
PubTator Score  14.87

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer