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Tbio
PIGT
GPI transamidase component PIG-T

Protein Summary
Description
Component of the GPI transamidase complex. Essential for transfer of GPI to proteins, particularly for formation of carbonyl intermediates. This gene encodes a protein that is involved in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is a glycolipid found on many blood cells and serves to anchor proteins to the cell surface. This protein is an essential component of the multisubunit enzyme, GPI transamidase. GPI transamidase mediates GPI anchoring in the endoplasmic reticulum, by catalyzing the transfer of fully assembled GPI units to proteins. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000279035
  • ENSP00000279035
  • ENSG00000124155
  • ENST00000279036
  • ENSP00000279036
  • ENST00000372689
  • ENSP00000361774
  • ENST00000543458
  • ENSP00000441577
  • ENST00000545755
  • ENSP00000443963

Symbol
  • NDAP
  • PNH2
  • CGI-06
  • MCAHS3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.83
cell type or tissue
0.8
cellular component
0.8
disease perturbation
0.79
transcription factor binding site profile
0.76


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.6   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 141   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.6   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 141   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
1
1
1
13.7
free cholesterol measurement
1
1
1
13.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
1
13.7
free cholesterol measurement
1
13.7
Pathways (7)
Attachment of GPI anchor to uPAR (R-HSA-162791)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Attachment of GPI anchor to uPAR
Reactome
Metabolism of proteins
Reactome
Post-translational modification: synthesis of GPI-anchored proteins
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Attachment of GPI anchor to uPAR
Metabolism of proteins
Post-translational modification: synthesis of GPI-anchored proteins
Post-translational protein modification
Gene Ontology Terms (9)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (66)
1 – 10 of 66
USP54
Tdark
Family: Enzyme
Novelty: 0.31344498
p_int: 0.999977118
p_ni: 0.000022882
Data Source: BioPlex
TNIP1
Tbio
Novelty: 0.0147254
p_int: 0.999957839
p_ni: 0.000042161
Data Source: BioPlex
CEP85L
Tbio
Novelty: 0.23631446
p_int: 0.999937863
p_ni: 0.000028806
p_wrong: 0.000033331
Score: 0.188
Data Source: BioPlex,STRINGDB
HOXC9
Tbio
Family: TF
Novelty: 0.02524418
p_int: 0.999868407
p_ni: 0.000128752
p_wrong: 0.00000284
Score: 0.185
Data Source: BioPlex,STRINGDB
RMND5B
Tbio
Novelty: 0.08447048
p_int: 0.999868117
p_ni: 0.000057518
p_wrong: 0.000074365
Score: 0.232
Data Source: BioPlex,STRINGDB
GPAA1
Tbio
Novelty: 0.01874575
p_int: 0.999740416
p_ni: 0.000259584
Score: 0.999
Data Source: BioPlex,STRINGDB
FAM136A
Tdark
Novelty: 0.4050275
p_int: 0.999074258
p_ni: 0.000925742
Data Source: BioPlex
ZMYND19
Tdark
Novelty: 0.3590069
p_int: 0.998973876
p_ni: 0.001026123
p_wrong: 1e-9
Data Source: BioPlex
ARMC8
Tbio
Novelty: 0.06820746
p_int: 0.996393025
p_ni: 0.003606975
Data Source: BioPlex
HELZ
Tbio
Family: Enzyme
Novelty: 0.08786982
p_int: 0.992357707
p_ni: 0.007642293
Data Source: BioPlex
Publication Statistics
PubMed Score  39.60

PubMed score by year
PubTator Score  12.56

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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