Tbio PIGT GPI transamidase component PIG-T

Protein Summary

Description

Component of the GPI transamidase complex. Essential for transfer of GPI to proteins, particularly for formation of carbonyl intermediates. This gene encodes a protein that is involved in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is a glycolipid found on many blood cells and serves to anchor proteins to the cell surface. This protein is an essential component of the multisubunit enzyme, GPI transamidase. GPI transamidase mediates GPI anchoring in the endoplasmic reticulum, by catalyzing the transfer of fully assembled GPI units to proteins. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]

Uniprot Accession IDs

• Q969N2
• B2RND5
• B7Z3N1
• B7Z7I8
• E1P622
• G8JLF5
• Q2NL69
• Q7Z3N7
• Q9BQY7
• Q9BQY8
• Q9UJG6
• Q9Y2Z5

Gene Name

• PIGT

Ensembl ID

• ENST00000279035
• ENSP00000279035
• ENSG00000124155
• ENST00000279036
• ENSP00000279036
• ENST00000372689
• ENSP00000361774
• ENST00000543458
• ENSP00000441577
• ENST00000545755
• ENSP00000443963

Symbol

• NDAP
• PNH2
• CGI-06
• MCAHS3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.83
cell type or tissue	0.8
cellular component	0.8
disease perturbation	0.79
transcription factor binding site profile	0.76

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.81   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 141   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.81   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 141   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (66)

Explore Interacting Targets

1 – 10 of 66

• See Interactions on String-DB

USP54

Tdark

Family:  Enzyme

Novelty:  0.31344498

p_int:  0.999977118

p_ni:  0.000022882

Data Source:  BioPlex

TNIP1

Tbio

Novelty:  0.0147254

p_int:  0.999957839

p_ni:  0.000042161

Data Source:  BioPlex

CEP85L

Tbio

Novelty:  0.23631446

p_int:  0.999937863

p_ni:  0.000028806

p_wrong:  0.000033331

Score:  0.188

Data Source:  BioPlex,STRINGDB

HOXC9

Tbio

Family:  TF

Novelty:  0.02524418

p_int:  0.999868407

p_ni:  0.000128752

p_wrong:  0.00000284

Score:  0.185

Data Source:  BioPlex,STRINGDB

RMND5B

Tbio

Novelty:  0.08447048

p_int:  0.999868117

p_ni:  0.000057518

p_wrong:  0.000074365

Score:  0.232

Data Source:  BioPlex,STRINGDB

GPAA1

Tbio

Novelty:  0.01874575

p_int:  0.999740416

p_ni:  0.000259584

Score:  0.999

Data Source:  BioPlex,STRINGDB

FAM136A

Tdark

Novelty:  0.4050275

p_int:  0.999074258

p_ni:  0.000925742

Data Source:  BioPlex

ZMYND19

Tdark

Novelty:  0.3590069

p_int:  0.998973876

p_ni:  0.001026123

p_wrong:  1e-9

Data Source:  BioPlex

ARMC8

Tbio

Novelty:  0.06820746

p_int:  0.996393025

p_ni:  0.003606975

Data Source:  BioPlex

HELZ

Tbio

Family:  Enzyme

Novelty:  0.08786982

p_int:  0.992357707

p_ni:  0.007642293

Data Source:  BioPlex

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (7)

Reactome (4)

KEGG (2)

UniProt (1)

Attachment of GPI anchor to uPAR (R-HSA-162791)

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1 – 4 of 4

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Attachment of GPI anchor to uPAR	7 targets	R-HSA-162791
Reactome	Metabolism of proteins	2050 targets	R-HSA-392499
Reactome	Post-translational modification: synthesis of GPI-anchored proteins	94 targets	R-HSA-163125
Reactome	Post-translational protein modification	1450 targets	R-HSA-597592

Name	Explore in Pharos	Explore in Source
Attachment of GPI anchor to uPAR	7 targets	R-HSA-162791
Metabolism of proteins	2050 targets	R-HSA-392499
Post-translational modification: synthesis of GPI-anchored proteins	94 targets	R-HSA-163125
Post-translational protein modification	1450 targets	R-HSA-597592

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (9)

Functions (1)

Components (5)

Processes (3)

Find Similar Targets

Items per page:

10

1 – 1 of 1

GO Term	Evidence	Assigned by
GPI-anchor transamidase activity	Inferred from Electronic Annotation (IEA)	Ensembl

Disease Associations ()

No disease associations found

GWAS Traits (2)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 2 of 2

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
high density lipoprotein cholesterol measurement	EFO_0004612	1	1	1		15.8
free cholesterol measurement	EFO_0008591	1	1	1		15.8

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 2 of 2

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
high density lipoprotein cholesterol measurement	EFO_0004612	1		15.8
free cholesterol measurement	EFO_0008591	1		15.8

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Complete proteome
Direct protein sequencing
Disease mutation
Disulfide bond
Endoplasmic reticulum
Epilepsy
Glycoprotein
GPI-anchor biosynthesis
Membrane

GWAS Trait Find Similar Targets

No Header	No Header
free cholesterol measurement
high density lipoprotein cholesterol measurement

MGI Phenotype Find Similar Targets

No Header	No Header
mortality/aging

IDG Resources

No IDG generated resources found

Orthologs (15)

1 – 5 of 15

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	phosphatidylinositol glycan anchor biosynthesis class T	VGNC:6237	458282
Macaque	phosphatidylinositol glycan anchor biosynthesis class T		710556
Mouse	phosphatidylinositol glycan anchor biosynthesis, class T	MGI:1926178	78928
Rat	phosphatidylinositol glycan anchor biosynthesis, class T	RGD:1307156	296360
Dog	phosphatidylinositol glycan anchor biosynthesis class T	VGNC:44542	477244

Species	Name	OMA	EggNOG	Inparanoid
Chimp	phosphatidylinositol glycan anchor biosynthesis class T
Macaque	phosphatidylinositol glycan anchor biosynthesis class T
Mouse	phosphatidylinositol glycan anchor biosynthesis, class T
Rat	phosphatidylinositol glycan anchor biosynthesis, class T
Dog	phosphatidylinositol glycan anchor biosynthesis class T

Publication Statistics

PubMed Score 43.81

PubMed score by year

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PubTator Score 12.56

PubTator score by year

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Related Publications

Text Mined References (23)

GeneRif Annotations (6)

Items per page:

10

0 of 0

PMID	Year	Title