You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
UBE2F
NEDD8-conjugating enzyme UBE2F

Protein Summary
Description
Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX2, but not RBX1, suggests that the RBX2-UBE2F complex neddylates specific target proteins, such as CUL5.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000272930
  • ENSP00000272930
  • ENSG00000184182
  • ENST00000409633
  • ENSP00000387299
  • ENST00000409953
  • ENSP00000386680
  • ENST00000414443
  • ENSP00000399183
  • ENST00000433241
  • ENSP00000393515
  • ENST00000441728
  • ENSP00000409749
  • ENST00000612130
  • ENSP00000478474

Symbol
  • NCE2
  • NCE2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
molecular function
0.96
transcription factor binding site profile
0.93
disease perturbation
0.9
virus perturbation
0.88


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.06   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 208   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.06   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 208   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
1
1
1
47.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
1
47.5
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ubiquitin conjugating enzyme E2 F (putative)
VGNC:14171
460054
Macaque
ubiquitin conjugating enzyme E2 F (putative)
695394
Mouse
MGI:1915171
67921
Rat
RGD:1307608
363284
Dog
ubiquitin conjugating enzyme E2 F (putative)
477421
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ubiquitin conjugating enzyme E2 F (putative)
Macaque
ubiquitin conjugating enzyme E2 F (putative)
Mouse
Rat
Dog
ubiquitin conjugating enzyme E2 F (putative)
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q969M7-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (93)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Immune System
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Immune System
Metabolism of proteins
Gene Ontology Terms (6)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (315)
1 – 10 of 315
DCUN1D3
Tdark
Novelty: 0.6055184
Score: 0.998
Data Source: STRINGDB
RNF7
Tbio
Novelty: 0.02532658
Score: 0.998
Data Source: STRINGDB
UBA3
Tbio
Novelty: 0.03962261
Score: 0.997
Data Source: Reactome,STRINGDB
NEDD8
Tbio
Novelty: 0.00305343
Score: 0.996
Data Source: Reactome,STRINGDB
CUL1
Tbio
Novelty: 0.00244476
Score: 0.994
Data Source: STRINGDB
RBX1
Tbio
Family: Enzyme
Novelty: 0.00596986
Score: 0.993
Data Source: STRINGDB
NAE1
Tchem
Novelty: 0.0283623
Score: 0.992
Data Source: Reactome,STRINGDB
DCUN1D1
Tbio
Novelty: 0.03122408
Score: 0.989
Data Source: Reactome,STRINGDB
DCUN1D5
Tdark
Novelty: 0.56719852
Score: 0.988
Data Source: STRINGDB
CUL3
Tbio
Novelty: 0.0028737
Score: 0.987
Data Source: STRINGDB
Publication Statistics
PubMed Score  12.06

PubMed score by year
PubTator Score  4.7

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer