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Tbio
LSM10
U7 snRNA-associated Sm-like protein LSm10

Protein Summary
Description
Appears to function in the U7 snRNP complex that is involved in histone 3'-end processing. Increases U7 snRNA levels but not histone 3'-end pre-mRNA processing activity, when overexpressed. Required for cell cycle progression from G1 to S phases. Binds specifically to U7 snRNA. Binds to the downstream cleavage product (DCP) of histone pre-mRNA in a U7 snRNP dependent manner.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000315732
  • ENSP00000319341
  • ENSG00000181817

Symbol
  • MST074
  • MSTP074
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.93
histone modification site profile
0.74
tissue sample
0.66
transcription factor binding site profile
0.65
transcription factor
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.48   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 60   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.48   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 60   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (7)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Metabolism of RNA
Reactome
Processing of Capped Intronless Pre-mRNA
Reactome
RNA Polymerase II Transcription
Reactome
RNA Polymerase II Transcription Termination
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Metabolism of RNA
Processing of Capped Intronless Pre-mRNA
RNA Polymerase II Transcription
RNA Polymerase II Transcription Termination
Gene Ontology Terms (12)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Protein-Protein Interactions (153)
1 – 10 of 153
LSM3
Tbio
Novelty: 0.10679982
p_int: 0.999999904
p_ni: 8.6e-8
p_wrong: 1e-8
Score: 0.971
Data Source: BioPlex,STRINGDB
SNRPF
Tdark
Novelty: 0.22699635
p_int: 0.999998541
p_ni: 0.000001294
p_wrong: 1.65e-7
Score: 0.998
Data Source: BioPlex,STRINGDB
LSM6
Tdark
Novelty: 0.24061873
p_int: 0.996346235
p_ni: 0.000002862
p_wrong: 0.003650903
Score: 0.934
Data Source: BioPlex,STRINGDB
SNRPGP15
Tdark
p_int: 0.988033892
p_ni: 0.000002516
p_wrong: 0.011963593
Data Source: BioPlex
SNRPE
Tbio
Novelty: 0.00150118
Score: 0.997
Data Source: STRINGDB
SNRPG
Tdark
Novelty: 0.75
Score: 0.997
Data Source: STRINGDB
LSM11
Tbio
Novelty: 0.12170385
Score: 0.996
Data Source: STRINGDB
SNRPD3
Tbio
Novelty: 0.01941268
Score: 0.995
Data Source: STRINGDB
SNRPB
Tbio
Novelty: 0.01137048
Score: 0.992
Data Source: STRINGDB
SLBP
Tbio
Novelty: 0.00692642
Score: 0.99
Data Source: STRINGDB
Publication Statistics
PubMed Score  6.48

PubMed score by year
PubTator Score  4.02

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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