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Tbio
LSM10
U7 snRNA-associated Sm-like protein LSm10

Protein Summary
Description
Appears to function in the U7 snRNP complex that is involved in histone 3'-end processing. Increases U7 snRNA levels but not histone 3'-end pre-mRNA processing activity, when overexpressed. Required for cell cycle progression from G1 to S phases. Binds specifically to U7 snRNA. Binds to the downstream cleavage product (DCP) of histone pre-mRNA in a U7 snRNP dependent manner.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000315732
  • ENSP00000319341
  • ENSG00000181817

Symbol
  • MST074
  • MSTP074
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.93
histone modification site profile
0.74
tissue sample
0.66
transcription factor binding site profile
0.65
transcription factor
0.58


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.87   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 60   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.87   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 60   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
LSM10, U7 small nuclear RNA associated
VGNC:9999
456754
Macaque
LSM10, U7 small nuclear RNA associated
713277
Mouse
MGI:2151045
116748
Rat
RGD:1584914
366468
Dog
LSM10, U7 small nuclear RNA associated
VGNC:42839
475335
Species
Name
OMA
EggNOG
Inparanoid
Chimp
LSM10, U7 small nuclear RNA associated
Macaque
LSM10, U7 small nuclear RNA associated
Mouse
Rat
Dog
LSM10, U7 small nuclear RNA associated
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q969L4-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (7)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Metabolism of RNA
Reactome
Processing of Capped Intronless Pre-mRNA
Reactome
RNA Polymerase II Transcription
Reactome
RNA Polymerase II Transcription Termination
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Metabolism of RNA
Processing of Capped Intronless Pre-mRNA
RNA Polymerase II Transcription
RNA Polymerase II Transcription Termination
Gene Ontology Terms (12)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Protein-Protein Interactions (153)
1 – 10 of 153
LSM3
Tbio
Novelty: 0.05044984
p_int: 0.999999904
p_ni: 8.6e-8
p_wrong: 1e-8
Score: 0.971
Data Source: BioPlex,STRINGDB
SNRPF
Tdark
Novelty: 0.17624854
p_int: 0.999998541
p_ni: 0.000001294
p_wrong: 1.65e-7
Score: 0.998
Data Source: BioPlex,STRINGDB
LSM6
Tbio
Novelty: 0.09507671
p_int: 0.996346235
p_ni: 0.000002862
p_wrong: 0.003650903
Score: 0.934
Data Source: BioPlex,STRINGDB
SNRPGP15
Tdark
p_int: 0.988033892
p_ni: 0.000002516
p_wrong: 0.011963593
Data Source: BioPlex
SNRPE
Tbio
Novelty: 0.02033423
Score: 0.997
Data Source: STRINGDB
SNRPG
Tbio
Novelty: 0.1684808
Score: 0.997
Data Source: STRINGDB
LSM11
Tbio
Novelty: 0.10694492
Score: 0.996
Data Source: STRINGDB
SNRPD3
Tbio
Novelty: 0.02022419
Score: 0.995
Data Source: STRINGDB
SNRPB
Tbio
Novelty: 0.01503535
Score: 0.992
Data Source: STRINGDB
SLBP
Tbio
Novelty: 0.00685735
Score: 0.99
Data Source: STRINGDB
Publication Statistics
PubMed Score  4.87

PubMed score by year
PubTator Score  4.02

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer