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Tbio
IL22RA2
Interleukin-22 receptor subunit alpha-2

Protein Summary
Description
Isoform 2 is a receptor for IL22. Binds to IL22, prevents interaction with the functional IL-22R complex and blocks the activity of IL22 (in vitro). May play an important role as an IL22 antagonist in the regulation of inflammatory responses. Isoform 1 may play a role in establishing and maintaining successful pregnancy. This gene encodes a member of the class II cytokine receptor family. The encoded soluble protein specifically binds to and inhibits interleukin 22 activity by blocking the interaction of interleukin 22 with its cell surface receptor. The encoded protein may be important in the regulation of inflammatory response, and has been implicated in the regulation of tumorigenesis in the colon. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000296980
  • ENSP00000296980
  • ENSG00000164485
  • ENST00000339602
  • ENSP00000340920
  • ENST00000349184
  • ENSP00000296979

Symbol
  • CRF2X
  • CRF2-10
  • CRF2-S1
  • IL-22BP
  • IL-22RA2
  • ZCYTOR16
  • IL-22R-alpha-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
microRNA
0.62
cell type or tissue
0.61
cell line
0.55
gene perturbation
0.51
trait
0.46


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.95   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 334   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.95   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 334   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (5)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Interleukin-20 family signaling
Reactome
Signaling by Interleukins
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
Interleukin-20 family signaling
Signaling by Interleukins
Gene Ontology Terms (9)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (87)
1 – 10 of 87
TBC1D31
Tdark
Novelty: 0.87979858
p_int: 0.900461767
p_ni: 0.082661327
p_wrong: 0.016876905
Score: 0.68
Data Source: BioPlex,STRINGDB
IL22
Tbio
Novelty: 0.0023754
Score: 0.988
Data Source: Reactome,STRINGDB
IL10RB
Tbio
Novelty: 0.00880915
Score: 0.974
Data Source: STRINGDB
IL22RA1
Tbio
Novelty: 0.01107638
Score: 0.944
Data Source: STRINGDB
TYK2
Tclin
Family: Kinase
Novelty: 0.00237955
Score: 0.929
Data Source: STRINGDB
JAK1
Tclin
Family: Kinase
Novelty: 0.00093625
Score: 0.918
Data Source: STRINGDB
IFNL2
Tbio
Novelty: 0.01468568
Score: 0.802
Data Source: STRINGDB
IL24
Tbio
Novelty: 0.00225887
Score: 0.78
Data Source: STRINGDB
IFNL3
Tbio
Novelty: 0.00069262
Score: 0.778
Data Source: STRINGDB
IL19
Tbio
Novelty: 0.0075728
Score: 0.768
Data Source: STRINGDB
Publication Statistics
PubMed Score  33.95

PubMed score by year
PubTator Score  20.61

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer