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Tbio
ZKSCAN4
Zinc finger protein with KRAB and SCAN domains 4

Protein Summary
Description
May be involved in the transcriptional activation of MDM2 and EP300 genes.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000377294
  • ENSP00000366509
  • ENSG00000187626

Symbol
  • ZNF307
  • ZNF427
  • ZNF307
  • ZNF427
  • ZSCAN36
  • P1P373C6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
histone modification site profile
0.77
cell type or tissue
0.73
tissue
0.64
cell line
0.56


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.06   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 223   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.06   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 223   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (35)
TYW3
Tdark
Novelty:  0.15183348
p_int:  1
Data Source:  BioPlex
ZNF232
Tdark
Family:  TF
Novelty:  0.68288358
p_int:  0.999999867
p_ni:  1.33e-7
Score:  0.679
Data Source:  BioPlex,STRINGDB
ZKSCAN3
Tbio
Family:  TF
Novelty:  0.06833314
p_int:  0.999999298
p_ni:  7.01e-7
Score:  0.866
Data Source:  BioPlex,STRINGDB
ZSCAN20
Tdark
Family:  TF
Novelty:  0.37441538
p_int:  0.999998508
p_ni:  0.000001492
Score:  0.729
Data Source:  BioPlex,STRINGDB
ZNF397
Tbio
Family:  TF
Novelty:  0.60034816
p_int:  0.999990621
p_ni:  0.000009379
Score:  0.808
Data Source:  BioPlex,STRINGDB
ZSCAN32
Tdark
Family:  TF
Novelty:  3.83392226
p_int:  0.999985087
p_ni:  0.000014903
p_wrong:  9e-9
Score:  0.83
Data Source:  BioPlex,STRINGDB
ZNF174
Tbio
Family:  TF
Novelty:  0.05970272
p_int:  0.999926269
p_ni:  0.000073613
p_wrong:  1.18e-7
Score:  0.834
Data Source:  BioPlex,STRINGDB
SCAND1
Tbio
Novelty:  0.06863895
p_int:  0.999910955
p_ni:  0.000089043
p_wrong:  2e-9
Score:  0.827
Data Source:  BioPlex,STRINGDB
PGBD1
Tbio
Novelty:  0.10454627
p_int:  0.999871037
p_ni:  0.000128944
p_wrong:  1.9e-8
Score:  0.862
Data Source:  BioPlex,STRINGDB
ZNF483
Tdark
Family:  TF
Novelty:  0.39891191
p_int:  0.999861715
p_ni:  0.000138278
p_wrong:  7e-9
Score:  0.82
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
RNA Polymerase II Transcription
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
RNA Polymerase II Transcription
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (29)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
4
6
0
1.2
94.8
1
3
0
1.1
84.9
peak expiratory flow
1
1
1
83.9
forced expiratory volume
1
1
1
81.4
vital capacity
1
1
1
75
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.2
94.8
0
1.1
84.9
peak expiratory flow
1
83.9
forced expiratory volume
1
81.4
vital capacity
1
75
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
zinc finger with KRAB and SCAN domains 4
VGNC:7943
471918
Dog
zinc finger with KRAB and SCAN domains 4
100682684
Cow
zinc finger with KRAB and SCAN domains 4
539620
Pig
zinc finger with KRAB and SCAN domains 4
100156123
Species
Name
OMA
EggNOG
Inparanoid
Chimp
zinc finger with KRAB and SCAN domains 4
Dog
zinc finger with KRAB and SCAN domains 4
Cow
zinc finger with KRAB and SCAN domains 4
Pig
zinc finger with KRAB and SCAN domains 4
Publication Statistics
PubMed Score 4.06
PubMed score by year
PubTator Score 2.55
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title