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Tbio
SLC38A4
Sodium-coupled neutral amino acid transporter 4

Protein Summary
Description
Sodium-dependent amino acid transporter. Mediates electrogenic symport of neutral amino acids and sodium ions. Has a broad specificity, with a preference for Ala, followed by His, Cys, Asn, Ser, Gly, Val, Thr, Gln and Met. May mediate sodium-independent transport of cationic amino acids, such as Arg and Lys. Amino acid uptake is pH-dependent, with low transport activities at pH 6.5, intermediate at pH 7.0 and highest between pH 7.5 and 8.5. SLC38A4 is found predominantly in liver and transports both cationic and neutral amino acids. The transport of cationic amino acids by SLC38A4 is Na(+) and pH independent, while the transport of neutral amino acids is Na(+) and pH dependent (Hatanaka et al., 2001 [PubMed 11342143]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000266579
  • ENSP00000266579
  • ENSG00000139209
  • ENST00000447411
  • ENSP00000389843

Symbol
  • ATA3
  • NAT3
  • SNAT4
  • ATA3
  • NAT3
  • PAAT
  • SNAT4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.93
kinase perturbation
0.66
PubMedID
0.65
disease perturbation
0.62
transcription factor
0.59


Related Tools
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 66.59   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 47   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 66.59   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 47   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
parental genotype effect measurement
1
1
1
73.2
birth weight
1
1
1
73.2
body height
2
2
2
71.8
C-reactive protein measurement
1
1
1
66.8
protein measurement
1
1
1
56.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
parental genotype effect measurement
1
73.2
birth weight
1
73.2
body height
2
71.8
C-reactive protein measurement
1
66.8
protein measurement
1
56.6
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 38 member 4
VGNC:8541
451853
Macaque
solute carrier family 38 member 4
702354
Mouse
MGI:1916604
69354
Rat
RGD:621836
170573
Dog
solute carrier family 38 member 4
VGNC:46395
486595
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 38 member 4
Macaque
solute carrier family 38 member 4
Mouse
Rat
Dog
solute carrier family 38 member 4
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q969I6-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (4)
Amino acid transport across the plasma membrane (R-HSA-352230)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amino acid transport across the plasma membrane
Reactome
SLC-mediated transmembrane transport
Reactome
Transport of inorganic cations/anions and amino acids/oligopeptides
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Amino acid transport across the plasma membrane
SLC-mediated transmembrane transport
Transport of inorganic cations/anions and amino acids/oligopeptides
Transport of small molecules
Gene Ontology Terms (7)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (73)
1 – 10 of 73
SCN11A
Tclin
Family:  IC
Novelty:  0.00145294
Score:  0.8
Data Source:  STRINGDB
SLC1A7
Tchem
Family:  Transporter
Novelty:  0.00067678
Score:  0.705
Data Source:  STRINGDB
AANAT
Tbio
Family:  Enzyme
Novelty:  0.0039709
Score:  0.693
Data Source:  STRINGDB
VPS18
Tbio
Novelty:  0.00726539
Score:  0.644
Data Source:  STRINGDB
ATP13A1
Tbio
Family:  Transporter
Novelty:  0.15331022
Score:  0.643
Data Source:  STRINGDB
ARL3
Tbio
Family:  Enzyme
Novelty:  0.01954965
Score:  0.638
Data Source:  STRINGDB
SLC7A8
Tbio
Family:  Transporter
Novelty:  0.03433454
Score:  0.623
Data Source:  STRINGDB
SLC1A4
Tbio
Family:  Transporter
Novelty:  0.01334316
Score:  0.609
Data Source:  STRINGDB
TCOF1
Tbio
Novelty:  0.00771294
Score:  0.606
Data Source:  STRINGDB
SLC1A5
Tchem
Family:  Transporter
Novelty:  0.00201741
Score:  0.604
Data Source:  STRINGDB
Publication Statistics
PubMed Score  66.59

PubMed score by year
PubTator Score  22.45

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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