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Tdark
DIRC1
Disrupted in renal carcinoma protein 1

Protein Summary
Description
Disruption of DIRC1 by translocation is associated with familial clear cell renal cancer. Overexpression of DIRC1 is associated with tumor progression and poor prognosis in gastric cancer. [provided by RefSeq, Mar 2019]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000308100
  • ENSP00000307860
  • ENSG00000174325
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.73
tissue
0.62
tissue sample
0.57
cellular component
0.52
cell line
0.49


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.86   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 30   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.86   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 30   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
pulse pressure measurement
1
1
1
33.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
pulse pressure measurement
1
33.4
Protein-Protein Interactions (28)
1 – 10 of 28
GTF3C3
Tdark
Novelty: 0.48547531
Score: 0.792
Data Source: STRINGDB
SUCLG1
Tbio
Family: Enzyme
Novelty: 0.01113643
Score: 0.718
Data Source: STRINGDB
MGAT5
Tbio
Family: Enzyme
Novelty: 0.00707747
Score: 0.703
Data Source: STRINGDB
CNTNAP5
Tbio
Novelty: 0.09102959
Score: 0.649
Data Source: STRINGDB
KRBA2
Tdark
Novelty: 1.26888218
Score: 0.642
Data Source: STRINGDB
ANKAR
Tdark
Novelty: 1.96721311
Score: 0.634
Data Source: STRINGDB
LRIG1
Tbio
Novelty: 0.01078663
Score: 0.628
Data Source: STRINGDB
HSPBAP1
Tbio
Novelty: 0.03321047
Score: 0.6
Data Source: STRINGDB
NEMP2
Tdark
Novelty: 1.47547409
Score: 0.586
Data Source: STRINGDB
POLK
Tbio
Family: Enzyme
Novelty: 0.01378154
Score: 0.533
Data Source: STRINGDB
Publication Statistics
PubMed Score  1.86

PubMed score by year
PubTator Score  1.25

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer