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Tbio
POP5
Ribonuclease P/MRP protein subunit POP5

Protein Summary
Description
Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of RNase MRP.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000341039
  • ENSP00000341791
  • ENSG00000167272
  • ENST00000357500
  • ENSP00000350098

Symbol
  • RPP2
  • RPP20
  • hPop5
  • HSPC004
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.96
transcription factor perturbation
0.91
virus perturbation
0.72
interacting protein
0.67
transcription factor binding site profile
0.65


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.13   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 42   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.13   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 42   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (79)
ENOX2
Tbio
Novelty:  0.02921191
p_int:  0.999999931
p_ni:  5.3e-8
p_wrong:  1.5e-8
Data Source:  BioPlex
ENOX1
Tbio
Novelty:  0.06620772
p_int:  0.999999923
p_ni:  6.7e-8
p_wrong:  1.1e-8
Data Source:  BioPlex
RPP40
Tbio
Family:  Enzyme
Novelty:  0.05981624
p_int:  0.999999068
p_ni:  9.32e-7
Score:  0.992
Data Source:  BioPlex,STRINGDB
RPP14
Tbio
Family:  Enzyme
Novelty:  0.10813341
p_int:  0.999998447
p_ni:  0.000001547
p_wrong:  6e-9
Score:  0.995
Data Source:  BioPlex,STRINGDB
NEPRO
Tbio
Novelty:  0.12980261
p_int:  0.999998272
p_ni:  0.000001728
Data Source:  BioPlex
RPP38
Tbio
Family:  Enzyme
Novelty:  0.06387902
p_int:  0.999963178
p_ni:  0.000036821
Score:  0.994
Data Source:  BioPlex,STRINGDB
POP7
Tbio
Family:  Enzyme
Novelty:  0.05460002
p_int:  0.999934981
p_ni:  0.000064958
p_wrong:  6.1e-8
Score:  0.986
Data Source:  BioPlex,STRINGDB
RPP25L
Tdark
Family:  Enzyme
Novelty:  1.39761189
p_int:  0.999903884
p_ni:  0.00007109
p_wrong:  0.000025027
Score:  0.931
Data Source:  BioPlex,STRINGDB
POP1
Tbio
Family:  Enzyme
Novelty:  2.92497626
p_int:  0.999829449
p_ni:  0.000170551
Score:  0.995
Data Source:  BioPlex,STRINGDB
C18orf21
Tdark
Novelty:  0.65363998
p_int:  0.9998132
p_ni:  0.000071405
p_wrong:  0.000115395
Score:  0.869
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Metabolism of RNA (R-HSA-8953854)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
tRNA processing
Reactome
tRNA processing in the nucleus
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
tRNA processing
tRNA processing in the nucleus
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
2
10
11
98
reticulocyte count
5
4
7
97.7
serum gamma-glutamyl transferase measurement
1
6
6
96.5
mean corpuscular volume
1
1
1
84.5
mean reticulocyte volume
1
1
1
80.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
11
98
reticulocyte count
7
97.7
serum gamma-glutamyl transferase measurement
6
96.5
mean corpuscular volume
1
84.5
mean reticulocyte volume
1
80.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
POP5 homolog, ribonuclease P/MRP subunit
VGNC:13346
452309
Mouse
MGI:2151221
117109
Dog
POP5 homolog, ribonuclease P/MRP subunit
VGNC:44817
477515
Horse
POP5 homolog, ribonuclease P/MRP subunit
VGNC:21699
100050189
Cow
POP5 homolog, ribonuclease P/MRP subunit
VGNC:33165
507410
Species
Name
OMA
EggNOG
Inparanoid
Chimp
POP5 homolog, ribonuclease P/MRP subunit
Mouse
Dog
POP5 homolog, ribonuclease P/MRP subunit
Horse
POP5 homolog, ribonuclease P/MRP subunit
Cow
POP5 homolog, ribonuclease P/MRP subunit
Publication Statistics
PubMed Score 42.13
PubMed score by year
PubTator Score 12.28
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title