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Tbio
FBXW7
F-box/WD repeat-containing protein 7

Protein Summary
Description
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds phosphorylated sites/phosphodegrons within target proteins and thereafter bring them to the SCF complex for ubiquitination (PubMed:22748924, PubMed:17434132, PubMed:26976582, PubMed:28727686). Identified substrates include cyclin-E (CCNE1 or CCNE2), DISC1, JUN, MYC, NOTCH1 released notch intracellular domain (NICD), NOTCH2, MCL1, and probably PSEN1 (PubMed:11565034, PubMed:12354302, PubMed:11585921, PubMed:15103331, PubMed:14739463, PubMed:17558397, PubMed:17873522, PubMed:22608923, PubMed:22748924, PubMed:29149593, PubMed:25775507, PubMed:28007894, PubMed:26976582, PubMed:28727686). Acts as a negative regulator of JNK signaling by binding to phosphorylated JUN and promoting its ubiquitination and subsequent degradation (PubMed:14739463). SCF(FBXW7) complex mediates the ub ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263981
  • ENSP00000263981
  • ENSG00000109670
  • ENST00000281708
  • ENSP00000281708
  • ENST00000296555
  • ENSP00000296555
  • ENST00000393956
  • ENSP00000377528
  • ENST00000603548
  • ENSP00000474725
  • ENST00000603841
  • ENSP00000474971

Symbol
  • FBW7
  • FBX30
  • SEL10
  • AGO
  • CDC4
  • FBW6
  • FBW7
  • hAgo
  • FBX30
  • FBXW6
  • SEL10
  • hCdc4
  • FBXO30
  • SEL-10
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
hub protein
0.94
kinase perturbation
0.91
transcription factor perturbation
0.88
kinase
0.87


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 752.99   (req: < 5)
Gene RIFs: 252   (req: <= 3)
Antibodies: 595   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 752.99   (req: >= 5)
Gene RIFs: 252   (req: > 3)
Antibodies: 595   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 46
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0