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Tbio
FBXW7
F-box/WD repeat-containing protein 7

Protein Classes
Protein Summary
Description
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds phosphorylated sites/phosphodegrons within target proteins and thereafter bring them to the SCF complex for ubiquitination (PubMed:22748924, PubMed:17434132, PubMed:26976582, PubMed:28727686). Identified substrates include cyclin-E (CCNE1 or CCNE2), DISC1, JUN, MYC, NOTCH1 released notch intracellular domain (NICD), NOTCH2, MCL1, and probably PSEN1 (PubMed:11565034, PubMed:12354302, PubMed:11585921, PubMed:15103331, PubMed:14739463, PubMed:17558397, PubMed:17873522, PubMed:22608923, PubMed:22748924, PubMed:29149593, PubMed:25775507, PubMed:28007894, PubMed:26976582, PubMed:28727686). Acts as a negative regulator of JNK signaling by binding to phosphorylated JUN and promoting its ubiquitination and subsequent degradation (PubMed:14739463). SCF(FBXW7) complex mediates the ub ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263981
  • ENSP00000263981
  • ENSG00000109670
  • ENST00000281708
  • ENSP00000281708
  • ENST00000296555
  • ENSP00000296555
  • ENST00000393956
  • ENSP00000377528
  • ENST00000603548
  • ENSP00000474725
  • ENST00000603841
  • ENSP00000474971

Symbol
  • FBW7
  • FBX30
  • SEL10
  • AGO
  • CDC4
  • FBW6
  • FBW7
  • hAgo
  • FBX30
  • FBXW6
  • SEL10
  • hCdc4
  • FBXO30
  • SEL-10
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
hub protein
0.94
kinase perturbation
0.91
transcription factor perturbation
0.88
kinase
0.87


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 625.44   (req: < 5)
Gene RIFs: 252   (req: <= 3)
Antibodies: 595   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 625.44   (req: >= 5)
Gene RIFs: 252   (req: > 3)
Antibodies: 595   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 46
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
2
1
2
73
2
2
1
1.1
71.7
eosinophil percentage of leukocytes
1
1
1
38.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
2
73
1
1.1
71.7
eosinophil percentage of leukocytes
1
38.6
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
F-box and WD repeat domain containing 7
VGNC:2989
461542
Macaque
F-box and WD repeat domain containing 7
695101
Mouse
MGI:1354695
50754
Rat
RGD:2321145
100360914
Dog
F-box and WD repeat domain containing 7
VGNC:40797
475465
Species
Name
OMA
EggNOG
Inparanoid
Chimp
F-box and WD repeat domain containing 7
Macaque
F-box and WD repeat domain containing 7
Mouse
Rat
Dog
F-box and WD repeat domain containing 7
Protein Structure (5 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q969H0-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (43)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 30
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Association of TriC/CCT with target proteins during biosynthesis
Reactome
Chaperonin-mediated protein folding
Reactome
Class I MHC mediated antigen processing & presentation
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Association of TriC/CCT with target proteins during biosynthesis
Chaperonin-mediated protein folding
Class I MHC mediated antigen processing & presentation
Gene Ontology Terms (58)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Direct Assay (IDA)
ParkinsonsUK-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
ParkinsonsUK-UCL
Inferred from Direct Assay (IDA)
ParkinsonsUK-UCL
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
ParkinsonsUK-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (533)
1 – 10 of 533
FBXW2
Tbio
Novelty: 0.01492058
p_int: 0.999999859
p_ni: 1.41e-7
Score: 0.931
Data Source: BioPlex,STRINGDB
PRR36
Tdark
Novelty: 0.46274399
p_int: 0.999999034
p_ni: 3e-9
p_wrong: 9.63e-7
Score: 0.282
Data Source: BioPlex,STRINGDB
SNX8
Tbio
Novelty: 0.02652492
p_int: 0.999996649
p_ni: 0.000003287
p_wrong: 6.4e-8
Score: 0.27
Data Source: BioPlex,STRINGDB
CREB3L1
Tbio
Family: TF
Novelty: 0.02295608
p_int: 0.999989394
p_ni: 0.000010518
p_wrong: 8.8e-8
Score: 0.235
Data Source: BioPlex,STRINGDB
TRAF2
Tbio
Novelty: 0.00983658
p_int: 0.999985823
p_ni: 0.000013965
p_wrong: 2.12e-7
Data Source: BioPlex
MYCBP2
Tbio
Family: Enzyme
Novelty: 0.00413684
p_int: 0.999979573
p_ni: 0.000020427
Score: 0.275
Data Source: BioPlex,STRINGDB
FBXO45
Tbio
Novelty: 0.05784607
p_int: 0.999968149
p_ni: 0.000007872
p_wrong: 0.000023979
Score: 0.506
Data Source: BioPlex,STRINGDB
TP53
Tchem
Family: TF
Novelty: 0.00001907
p_int: 0.999684998
p_ni: 0.000315002
Score: 0.856
Data Source: BioPlex,STRINGDB
CUL1
Tbio
Novelty: 0.00244476
p_int: 0.981840505
p_ni: 0.018159495
Score: 0.998
Data Source: BioPlex,Reactome,STRINGDB
RAE1
Tbio
Novelty: 0.01342883
p_int: 0.799957455
p_ni: 0.200042545
Score: 0.438
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  625.44

PubMed score by year
PubTator Score  342.37

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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