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Tbio
NKD1
Protein naked cuticle homolog 1

Protein Summary
Description
Cell autonomous antagonist of the canonical Wnt signaling pathway. May activate a second Wnt signaling pathway that controls planar cell polarity. In the mouse, Nkd is a Dishevelled (see DVL1; MIM 601365)-binding protein that functions as a negative regulator of the Wnt (see WNT1; MIM 164820)-beta-catenin (see MIM 116806)-Tcf (see MIM 602272) signaling pathway.[supplied by OMIM, Jun 2003]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000268459
  • ENSP00000268459
  • ENSG00000140807

Symbol
  • NKD
  • Naked1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
microRNA
0.67
PubMedID
0.63
histone modification site profile
0.6
biological process
0.59
tissue sample
0.57


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 69.38   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 139   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 69.38   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 139   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (132)
DVL1
Tchem
Novelty:  0.00356876
Score:  0.986
Data Source:  STRINGDB
DVL2
Tbio
Novelty:  0.00833084
Score:  0.966
Data Source:  STRINGDB
DVL3
Tbio
Novelty:  0.01606014
Score:  0.961
Data Source:  STRINGDB
JUN
Tchem
Family:  TF
Novelty:  0.00006856
Score:  0.912
Data Source:  STRINGDB
PPP2R5D
Tbio
Family:  Enzyme
Novelty:  0.03990599
Score:  0.905
Data Source:  STRINGDB
FOS
Tbio
Family:  TF
Novelty:  0.00006103
Score:  0.902
Data Source:  STRINGDB
PPP2CA
Tchem
Family:  Enzyme
Novelty:  0.00496839
Score:  0.837
Data Source:  STRINGDB
PPP2R3A
Tbio
Family:  Enzyme
Novelty:  0.0350873
Score:  0.826
Data Source:  STRINGDB
PPP2R1A
Tbio
Family:  Enzyme
Novelty:  0.01134139
Score:  0.82
Data Source:  STRINGDB
NKD2
Tbio
Novelty:  0.04042015
Score:  0.819
Data Source:  STRINGDB
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
11
4
2
1.7
98.7
2
2
0
1.5
88.7
2
2
0
2
87.8
Oral ulcer
1
1
0
1.1
82.5
1
1
1
79.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
1.7
98.7
0
1.5
88.7
0
2
87.8
Oral ulcer
0
1.1
82.5
1
79.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
naked cuticle homolog 1
VGNC:9388
465164
Macaque
naked cuticle homolog 1
698036
Mouse
MGI:2135954
93960
Rat
RGD:1308491
364952
Dog
naked cuticle homolog 1
VGNC:43828
487288
Species
Name
OMA
EggNOG
Inparanoid
Chimp
naked cuticle homolog 1
Macaque
naked cuticle homolog 1
Mouse
Rat
Dog
naked cuticle homolog 1
Publication Statistics
PubMed Score 69.38
PubMed score by year
PubTator Score 19.99
PubTator score by year
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Related Publications
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PMID
Year
Title