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Tbio
RFK
Riboflavin kinase

Protein Summary
Description
Catalyzes the phosphorylation of riboflavin (vitamin B2) to form flavin-mononucleotide (FMN), hence rate-limiting enzyme in the synthesis of FAD. Essential for TNF-induced reactive oxygen species (ROS) production. Through its interaction with both TNFRSF1A and CYBA, physically and functionally couples TNFRSF1A to NADPH oxidase. TNF-activation of RFK may enhance the incorporation of FAD in NADPH oxidase, a critical step for the assembly and activation of NADPH oxidase. Riboflavin kinase (RFK; EC 2.7.1.26) is an essential enzyme that catalyzes the phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN), an obligatory step in vitamin B2 utilization and flavin cofactor synthesis (Karthikeyan et al., 2003 [PubMed 12623014]).[supplied by OMIM, Nov 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000376736
  • ENSP00000365926
  • ENSG00000135002

Symbol
  • RIFK
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
disease perturbation
0.93
molecular function
0.91
histone modification site profile
0.86
transcription factor perturbation
0.8


Related Tools
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 105   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 144   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 105   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 144   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
riboflavin kinase
VGNC:13953
744462
Mouse
MGI:1914688
54391
Rat
RGD:1549748
499328
Cow
riboflavin kinase
VGNC:33891
514697
Opossum
riboflavin kinase
100019592
Species
Name
OMA
EggNOG
Inparanoid
Chimp
riboflavin kinase
Mouse
Rat
Cow
riboflavin kinase
Opossum
riboflavin kinase
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q969G6-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (13)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of vitamins and cofactors
Reactome
Metabolism of water-soluble vitamins and cofactors
Reactome
Vitamin B2 (riboflavin) metabolism
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of vitamins and cofactors
Metabolism of water-soluble vitamins and cofactors
Vitamin B2 (riboflavin) metabolism
Gene Ontology Terms (11)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (77)
1 – 10 of 77
FLAD1
Tbio
Family:  Enzyme
Novelty:  0.02230368
Score:  0.996
Data Source:  STRINGDB
ENPP3
Tchem
Family:  Enzyme
Novelty:  0.00414129
Score:  0.918
Data Source:  STRINGDB
ENPP1
Tchem
Family:  Enzyme
Novelty:  0.00256132
Score:  0.916
Data Source:  STRINGDB
BLVRB
Tbio
Family:  Enzyme
Novelty:  0.00705559
Score:  0.9
Data Source:  STRINGDB
YKT6
Tbio
Novelty:  0.01591063
Score:  0.852
Data Source:  STRINGDB
ACP5
Tbio
Family:  Enzyme
Novelty:  0.00034703
Score:  0.831
Data Source:  STRINGDB
UFM1
Tbio
Novelty:  0.0215914
Score:  0.825
Data Source:  STRINGDB
ACP2
Tbio
Family:  Enzyme
Novelty:  0.00355652
Score:  0.823
Data Source:  STRINGDB
TNFRSF1A
Tchem
Novelty:  0.00037847
Score:  0.823
Data Source:  STRINGDB
MEMO1
Tbio
Novelty:  0.0506558
Score:  0.807
Data Source:  STRINGDB
Publication Statistics
PubMed Score  105.00

PubMed score by year
PubTator Score  19.02

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer