Tbio SMARCE1 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1

Protein Summary

Description

Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Required for the coactivation of estrogen responsive promoters by SWI/SNF complexes and the SRC/p160 family of histone acetyltransferases (HATs). Also specifically interacts with the CoREST corepressor resulting in repression of neuronal specific gene promoters in non-neuronal cells. The protein encoded by this gene is part of the large ATP-dependent chromatin remodeling complex SWI/SNF, which is required for transcriptional activation of genes normally repressed by chromatin. The encoded protein, either alone or when in the SWI/SNF complex, can bind to 4-way junction DNA, which is thought to mimic the topology of DNA as it enters or exits the nucleosome. The protein contains a DNA-binding HMG domain, but disruption of this domain does not abolish the DNA-binding or nucleosome-displacement activities of the SWI/SNF complex. Unlike most of the SWI/SNF complex proteins, this protein has no yeast counterpart. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q969G3
• B3KMC1
• B4DFR4
• C0IMW4
• C0IMW5
• C0IMW7
• H7C3F6
• O43539

Gene Name

• SMARCE1

Ensembl ID

• ENST00000264640
• ENSP00000466608
• ENSG00000073584
• ENST00000348513
• ENSP00000323967
• ENST00000377808
• ENSP00000367039
• ENST00000400122
• ENSP00000411607
• ENST00000447024
• ENSP00000392958
• ENST00000578044
• ENSP00000464511
• ENST00000643318
• ENSP00000494771
• ENST00000643683
• ENSP00000496094
• ENST00000644701
• ENSP00000496097
• ENST00000647508
• ENSP00000496445

Symbol

• BAF57
• CSS5
• BAF57

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein complex	1
molecular function	0.99
transcription factor perturbation	0.97
kinase perturbation	0.91
histone modification site profile	0.88

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 62.8   (req: < 5)

Gene RIFs: 36   (req: <= 3)

Antibodies: 353   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 62.8   (req: >= 5)

Gene RIFs: 36   (req: > 3)

Antibodies: 353   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0