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Tchem
KISS1R
KiSS-1 receptor

Protein Summary
Description
Receptor for metastin (kisspeptin-54 or kp-54), a C-terminally amidated peptide of KiSS1. KiSS1 is a metastasis suppressor protein that suppresses metastases in malignant melanomas and in some breast carcinomas without affecting tumorigenicity. The metastasis suppressor properties may be mediated in part by cell cycle arrest and induction of apoptosis in malignant cells. The receptor is essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/KISS1R system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood. The receptor is also probably involved in the regulation and fine-tuning of trophoblast invasion generated by the trophoblast itself. Analysis of the transduction pathways activated by the receptor identifies coupling to phospholipase C and intracellular calcium release through pertussis toxin-insensitive G(q) proteins. The protein encoded by this gene is a galanin-like G protein-coupled recepto ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000234371
  • ENSP00000234371
  • ENSG00000116014

Symbol
  • AXOR12
  • GPR54
  • HH8
  • CPPB1
  • GPR54
  • AXOR12
  • KISS-1R
  • HOT7T175
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.9
biological process
0.77
biological term
0.7
phenotype
0.63
transcription factor
0.6


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 357.49   (req: < 5)
Gene RIFs: 75   (req: <= 3)
Antibodies: 315   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 357.49   (req: >= 5)
Gene RIFs: 75   (req: > 3)
Antibodies: 315   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 207
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (207)
CHEMBL4539775
Rendered image for CHEMBL4539775
CHEMBL4533110,CHEMBL4584512
Rendered image for CHEMBL4533110,CHEMBL4584512
CHEMBL3314227
Rendered image for CHEMBL3314227
CHEMBL3314217
Rendered image for CHEMBL3314217
CHEMBL4462883
Rendered image for CHEMBL4462883
CHEMBL3086282
Rendered image for CHEMBL3086282
CHEMBL3087927
Rendered image for CHEMBL3087927
CHEMBL3314226
Rendered image for CHEMBL3314226
CHEMBL3314216
Rendered image for CHEMBL3314216
CHEMBL3314224
Rendered image for CHEMBL3314224
Protein-Protein Interactions (206)
KISS1
Tbio
Novelty:  0.00096537
Score:  0.997
Data Source:  Reactome,STRINGDB
GNRH1
Tbio
Novelty:  0.00020807
Score:  0.994
Data Source:  STRINGDB
GNRHR
Tclin
Family:  GPCR
Novelty:  0.00203671
Score:  0.979
Data Source:  STRINGDB
TAC3
Tchem
Novelty:  0.001685
Score:  0.979
Data Source:  STRINGDB
PROK2
Tbio
Novelty:  0.00512397
Score:  0.965
Data Source:  STRINGDB
NPS
Tbio
Novelty:  0.00692108
Score:  0.964
Data Source:  STRINGDB
NPFF
Tbio
Novelty:  0.00489546
Score:  0.961
Data Source:  STRINGDB
UTS2R
Tchem
Family:  GPCR
Novelty:  0.00865846
Score:  0.957
Data Source:  STRINGDB
GNRH2
Tbio
Novelty:  0.0027348
Score:  0.955
Data Source:  STRINGDB
QRFP
Tbio
Novelty:  0.02210773
Score:  0.941
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (9)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

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Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (q) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Peptide ligand-binding receptors
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
G alpha (q) signalling events
GPCR downstream signalling
GPCR ligand binding
Peptide ligand-binding receptors
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
3
12
19
99.5
reticulocyte count
7
9
26
99.2
heel bone mineral density
3
3
5
93.2
basophil count
3
3
3
91
basophil percentage of leukocytes
2
2
2
83.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
19
99.5
reticulocyte count
26
99.2
heel bone mineral density
5
93.2
basophil count
3
91
basophil percentage of leukocytes
2
83.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
KISS1 receptor
VGNC:2333
741289
Macaque
KISS1 receptor
574305
Mouse
MGI:2148793
114229
Rat
RGD:70930
78976
Dog
KISS1 receptor
VGNC:42421
612374
Species
Name
OMA
EggNOG
Inparanoid
Chimp
KISS1 receptor
Macaque
KISS1 receptor
Mouse
Rat
Dog
KISS1 receptor
Publication Statistics
PubMed Score 357.49
PubMed score by year
PubTator Score 268.32
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title