Protein Classes
Protein Summary
Receptor for metastin (kisspeptin-54 or kp-54), a C-terminally amidated peptide of KiSS1. KiSS1 is a metastasis suppressor protein that suppresses metastases in malignant melanomas and in some breast carcinomas without affecting tumorigenicity. The metastasis suppressor properties may be mediated in part by cell cycle arrest and induction of apoptosis in malignant cells. The receptor is essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/KISS1R system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood. The receptor is also probably involved in the regulation and fine-tuning of trophoblast invasion generated by the trophoblast itself. Analysis of the transduction pathways activated by the receptor identifies coupling to phospholipase C and intracellular calcium release through pertussis toxin-insensitive G(q) proteins. The protein encoded by this gene is a galanin-like G protein-coupled recepto ...more
- ENST00000234371
- ENSP00000234371
- ENSG00000116014
- AXOR12
- GPR54
- HH8
- CPPB1
- GPR54
- AXOR12
- KISS-1R
- HOT7T175
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
cell type or tissue | 0.9 | ||
biological process | 0.77 | ||
biological term | 0.7 | ||
phenotype | 0.63 | ||
transcription factor | 0.6 | ||
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 288.48 (req: < 5)
Gene RIFs: 75 (req: <= 3)
Antibodies: 315 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 288.48 (req: >= 5)
Gene RIFs: 75 (req: > 3)
Antibodies: 315 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 4
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 152
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Active Ligands (152)
1 – 10 of 152
Pathways (9)
Reactome (7)
KEGG (2)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 7
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Class A/1 (Rhodopsin-like receptors) | ||||
Reactome | G alpha (q) signalling events | ||||
Reactome | GPCR downstream signalling | ||||
Reactome | GPCR ligand binding | ||||
Reactome | Peptide ligand-binding receptors | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Class A/1 (Rhodopsin-like receptors) | ||||
G alpha (q) signalling events | ||||
GPCR downstream signalling | ||||
GPCR ligand binding | ||||
Peptide ligand-binding receptors | ||||
Gene Ontology Terms (9)
Functions (2)
Components (5)
Processes (2)
Items per page:
10
1 – 2 of 2
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Protein-Protein Interactions (206)
1 – 10 of 206
KISS1
Novelty: 0.00111063
Score: 0.997
Data Source: Reactome,STRINGDB
GNRH1
Novelty: 0.00024998
Score: 0.994
Data Source: STRINGDB
GNRHR
Family: GPCR
Novelty: 0.00227536
Score: 0.979
Data Source: STRINGDB
TAC3
Novelty: 0.00210451
Score: 0.979
Data Source: STRINGDB
PROK2
Novelty: 0.00558025
Score: 0.965
Data Source: STRINGDB
NPS
Novelty: 0.00011983
Score: 0.964
Data Source: STRINGDB
NPFF
Novelty: 0.00350925
Score: 0.961
Data Source: STRINGDB
UTS2R
Family: GPCR
Novelty: 0.01075176
Score: 0.957
Data Source: STRINGDB
GNRH2
Novelty: 0.00305192
Score: 0.955
Data Source: STRINGDB
QRFP
Novelty: 0.02279173
Score: 0.941
Data Source: STRINGDB
Publication Statistics
PubMed Score 288.48
PubMed score by year
PubTator Score 268.32
PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Sequence
MHTVATSGPNASWGAPANASGCPGCGANASDGPVPSPRAVDAWLVPLFFAALMLLGLVGNSLVIYVICRH
1-70
KPMRTVTNFYIANLAATDVTFLLCCVPFTALLYPLPGWVLGDFMCKFVNYIQQVSVQATCATLTAMSVDR
70-140
WYVTVFPLRALHRRTPRLALAVSLSIWVGSAAVSAPVLALHRLSPGPRAYCSEAFPSRALERAFALYNLL
140-210
ALYLLPLLATCACYAAMLRHLGRVAVRPAPADSALQGQVLAERAGAVRAKVSRLVAAVVLLFAACWGPIQ
210-280
LFLVLQALGPAGSWHPRSYAAYALKTWAHCMSYSNSALNPLLYAFLGSHFRQAFRRVCPCAPRRPRRPRR
280-350
PGPSDPAAPHAELLRLGSHPAPARAQKPGSSGLAARGLCVLGEDNAPL
350-398
MHTVATSGPNASWGAPANASGCPGCGANASDGPVPSPRAVDAWLVPLFFAALMLLGLVGNSLVIYVICRHKPMRTVTNFYIANLAATDVTFLLCCVPFTALLYPLPGWVLGDFMCKFVNYIQQVSVQATCATLTAMSVDRWYVTVFPLRALHRRTPRLALAVSLSIWVGSAAVSAPVLALHRLSPGPRAYCSEAFPSRALERAFALYNLLALYLLPLLATCACYAAMLRHLGRVAVRPAPADSALQGQVLAERAGAVRAKVSRLVAAVVLLFAACWGPIQLFLVLQALGPAGSWHPRSYAAYALKTWAHCMSYSNSALNPLLYAFLGSHFRQAFRRVCPCAPRRPRRPRRPGPSDPAAPHAELLRLGSHPAPARAQKPGSSGLAARGLCVLGEDNAPL
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