Protein Classes
Protein Summary
Receptor for metastin (kisspeptin-54 or kp-54), a C-terminally amidated peptide of KiSS1. KiSS1 is a metastasis suppressor protein that suppresses metastases in malignant melanomas and in some breast carcinomas without affecting tumorigenicity. The metastasis suppressor properties may be mediated in part by cell cycle arrest and induction of apoptosis in malignant cells. The receptor is essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/KISS1R system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood. The receptor is also probably involved in the regulation and fine-tuning of trophoblast invasion generated by the trophoblast itself. Analysis of the transduction pathways activated by the receptor identifies coupling to phospholipase C and intracellular calcium release through pertussis toxin-insensitive G(q) proteins. The protein encoded by this gene is a galanin-like G protein-coupled recepto ...more
- ENST00000234371
- ENSP00000234371
- ENSG00000116014
- AXOR12
- GPR54
- HH8
- CPPB1
- GPR54
- AXOR12
- KISS-1R
- HOT7T175
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
cell type or tissue | 0.9 | ||
biological process | 0.77 | ||
biological term | 0.7 | ||
phenotype | 0.63 | ||
transcription factor | 0.6 | ||
Related Tools
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 350.61 (req: < 5)
Gene RIFs: 75 (req: <= 3)
Antibodies: 315 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 350.61 (req: >= 5)
Gene RIFs: 75 (req: > 3)
Antibodies: 315 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 4
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 152
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Active Ligands (152)
1 – 10 of 152
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | KISS1 receptor | VGNC:2333 | 741289 | |||||
Macaque | KISS1 receptor | 574305 | ||||||
Mouse | MGI:2148793 | 114229 | ||||||
Rat | RGD:70930 | 78976 | ||||||
Dog | KISS1 receptor | VGNC:42421 | 612374 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | KISS1 receptor | |||||
Macaque | KISS1 receptor | |||||
Mouse | ||||||
Rat | ||||||
Dog | KISS1 receptor | |||||
Protein Structure (0 Structures, 1 AlphaFold Model)
Pathways (9)
Reactome (7)
KEGG (2)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 7
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Class A/1 (Rhodopsin-like receptors) | ||||
Reactome | G alpha (q) signalling events | ||||
Reactome | GPCR downstream signalling | ||||
Reactome | GPCR ligand binding | ||||
Reactome | Peptide ligand-binding receptors | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Class A/1 (Rhodopsin-like receptors) | ||||
G alpha (q) signalling events | ||||
GPCR downstream signalling | ||||
GPCR ligand binding | ||||
Peptide ligand-binding receptors | ||||
Gene Ontology Terms (9)
Functions (2)
Components (5)
Processes (2)
Items per page:
10
1 – 2 of 2
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Protein-Protein Interactions (206)
1 – 10 of 206
KISS1
Novelty: 0.00096537
Score: 0.997
Data Source: Reactome,STRINGDB
GNRH1
Novelty: 0.00020807
Score: 0.994
Data Source: STRINGDB
GNRHR
Family: GPCR
Novelty: 0.00203671
Score: 0.979
Data Source: STRINGDB
TAC3
Novelty: 0.001685
Score: 0.979
Data Source: STRINGDB
PROK2
Novelty: 0.00512397
Score: 0.965
Data Source: STRINGDB
NPS
Novelty: 0.00692108
Score: 0.964
Data Source: STRINGDB
NPFF
Novelty: 0.00489546
Score: 0.961
Data Source: STRINGDB
UTS2R
Family: GPCR
Novelty: 0.00865846
Score: 0.957
Data Source: STRINGDB
GNRH2
Novelty: 0.0027348
Score: 0.955
Data Source: STRINGDB
QRFP
Novelty: 0.02210773
Score: 0.941
Data Source: STRINGDB
Publication Statistics
PubMed Score 350.61
PubMed score by year
PubTator Score 268.32
PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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