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Tbio
FATE1
Fetal and adult testis-expressed transcript protein

Protein Summary
Description
Involved in the regulation of endoplasmic reticulum (ER)-mitochondria coupling. Negatively regulates the ER-mitochondria distance and Ca(2+) transfer from ER to mitochondria possibly implicating it in the regulation of apoptosis (PubMed:27402544). May collaborate with RNF183 to restrain BIK protein levels thus regulating apoptotic signaling (PubMed:26567849). This gene encodes a cancer-testis antigen that is highly expressed in hepatocellular carcinomas and other tumors and weakly expressed in normal tissues except testis. The protein is strongly expressed in spermatogonia, primary spermatocytes, and Sertoli cells in seminiferous tubules. This protein may have a role in the control of early testicular differentiation and cell proliferation. [provided by RefSeq, Jan 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000370350
  • ENSP00000359375
  • ENSG00000147378

Symbol
  • FATE
  • CT43
  • FATE
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.46
cell line
0.43
tissue
0.41
biological term
0.33
interacting protein
0.31


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.91   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 254   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.91   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 254   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (28)
HSF4
Tbio
Family:  TF
Novelty:  0.01736563
Score:  0.658
Data Source:  STRINGDB
SPANXD
Tdark
Novelty:  0.22064161
Score:  0.634
Data Source:  STRINGDB
FMR1NB
Tbio
Novelty:  0.1016511
Score:  0.633
Data Source:  STRINGDB
RNF183
Tbio
Novelty:  0.34873861
Score:  0.626
Data Source:  STRINGDB
SPANXC
Tbio
Novelty:  0.14907666
Score:  0.585
Data Source:  STRINGDB
TOPAZ1
Tdark
Novelty:  0.42409276
Score:  0.583
Data Source:  STRINGDB
TAF7
Tbio
Novelty:  0.05316615
Score:  0.569
Data Source:  STRINGDB
NXF5
Tbio
Novelty:  0.18468434
Score:  0.561
Data Source:  STRINGDB
SYNGR1
Tbio
Novelty:  0.08034637
Score:  0.539
Data Source:  STRINGDB
NXF2
Tbio
Novelty:  0.04733504
Score:  0.53
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
fetal and adult testis expressed 1
VGNC:1379
736536
Mouse
MGI:1925155
77905
Dog
fetal and adult testis expressed 1
VGNC:40746
481076
Horse
fetal and adult testis expressed 1
VGNC:17927
100629779
Cow
fetal and adult testis expressed 1
VGNC:28878
281153
Species
Name
OMA
EggNOG
Inparanoid
Chimp
fetal and adult testis expressed 1
Mouse
Dog
fetal and adult testis expressed 1
Horse
fetal and adult testis expressed 1
Cow
fetal and adult testis expressed 1
Publication Statistics
PubMed Score 24.91
PubMed score by year
PubTator Score 3.33
PubTator score by year
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Related Publications
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PMID
Year
Title