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Tdark
TCEAL3
Transcription elongation factor A protein-like 3

Protein Classes
Protein Summary
Description
May be involved in transcriptional regulation. This gene encodes a member of the transcription elongation factor A (SII)-like (TCEAL) gene family. Members of this family contain TFA domains and may function as nuclear phosphoproteins that modulate transcription in a promoter context-dependent manner. Multiple family members are located on the X chromosome. Alternative splicing results in multiple transcript variants encoding a single isoform. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000243286
  • ENSP00000243286
  • ENSG00000196507
  • ENST00000372627
  • ENSP00000361710
  • ENST00000372628
  • ENSP00000361711

Symbol
  • WEX8
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (protein) perturbation
0.83
histone modification site profile
0.7
tissue sample
0.62
tissue
0.54
cell line
0.45


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.1   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 100   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.1   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 100   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
1
1
1
55.2
mean platelet volume
1
1
1
47.7
lymphocyte percentage of leukocytes
1
1
1
12.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
1
55.2
mean platelet volume
1
47.7
lymphocyte percentage of leukocytes
1
12.1
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
transcription elongation factor A like 3
696692
Mouse
MGI:1923939
66104
Dog
transcription elongation factor A like 5
100688866
Horse
transcription elongation factor A like 6
100066870
Pig
transcription elongation factor A like 3
100524295
Species
Name
OMA
EggNOG
Inparanoid
Macaque
transcription elongation factor A like 3
Mouse
Dog
transcription elongation factor A like 5
Horse
transcription elongation factor A like 6
Pig
transcription elongation factor A like 3
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q969E4-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (2)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (29)
1 – 10 of 29
TCEAL5
Tdark
Novelty:  1.78893063
p_int:  0.999999998
p_wrong:  2e-9
Data Source:  BioPlex
BEX5
Tdark
Novelty:  0.2964824
Score:  0.701
Data Source:  STRINGDB
TCEAL1
Tbio
Novelty:  0.02210924
Score:  0.697
Data Source:  STRINGDB
GLRA3
Tchem
Family:  IC
Novelty:  0.0209653
Score:  0.679
Data Source:  STRINGDB
HMGA1
Tbio
Family:  TF
Novelty:  0.00185669
Score:  0.632
Data Source:  STRINGDB
TCEAL8
Tdark
Novelty:  1.0765394
Score:  0.618
Data Source:  STRINGDB
RAB9B
Tbio
Family:  Enzyme
Novelty:  0.19952686
Score:  0.617
Data Source:  STRINGDB
BEX3
Tbio
Novelty:  0.02578005
Score:  0.614
Data Source:  STRINGDB
NUDT10
Tbio
Family:  Enzyme
Novelty:  0.01340726
Score:  0.592
Data Source:  STRINGDB
NUDT11
Tbio
Family:  Enzyme
Novelty:  0.19004372
Score:  0.592
Data Source:  STRINGDB
Publication Statistics
PubMed Score  1.10

PubMed score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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