Tbio UCN3 Urocortin-3

Protein Summary

Description

Suppresses food intake, delays gastric emptying and decreases heat-induced edema. Might represent an endogenous ligand for maintaining homeostasis after stress. This gene encodes a member of the sauvagine/corticotropin-releasing factor/urotensin I family of proteins. The encoded preproprotein is proteolytically processed to generate the mature peptide hormone, which is secreted by pancreatic beta and alpha cells. This hormone is an endogenous ligand for corticotropin-releasing factor receptor 2 and may regulate insulin secretion in response to plasma glucose levels. Patients with type 2 diabetes exhibit reduced levels of the encoded protein in beta cells. In the brain, the encoded protein may be responsible for the effects of stress on appetite. [provided by RefSeq, May 2016]

Uniprot Accession IDs

• Q969E3
• Q496H2
• Q5SR91

Gene Name

• UCN3

Ensembl ID

• ENST00000380433
• ENSP00000369798
• ENSG00000178473

Symbol

• SPC
• SCP
• SPC
• UCNIII

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.74
biological process	0.65
cell type or tissue	0.57
cell line	0.49
tissue	0.49

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 111.09   (req: < 5)

Gene RIFs: 23   (req: <= 3)

Antibodies: 152   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 111.09   (req: >= 5)

Gene RIFs: 23   (req: > 3)

Antibodies: 152   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

GWAS Traits (3)

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GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
triglyceride measurement	EFO_0004530	2	2	2		52.4
IGF-1 measurement	EFO_0004627	1	1	1		38.8
sleep duration	EFO_0005271	1	1	1		12.1

• Explore on Target Illumination GWAS Analytics (TIGA)

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
triglyceride measurement	EFO_0004530	2		52.4
IGF-1 measurement	EFO_0004627	1		38.8
sleep duration	EFO_0005271	1		12.1

Reset Zoom  Beta Count   Odds Ratio

Orthologs (12)

1 – 5 of 12

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	urocortin 3	VGNC:5872	450276
Macaque	urocortin 3		711921
Mouse	urocortin 3	MGI:1932970	83428
Rat	urocortin 3	RGD:1562213	498791
Dog	urocortin 3	VGNC:48110	100856134

Species	Name	OMA	EggNOG	Inparanoid
Chimp	urocortin 3
Macaque	urocortin 3
Mouse	urocortin 3
Rat	urocortin 3
Dog	urocortin 3

Protein Structure (2 Structures, 1 AlphaFold Model)

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Representation

  axes   backbone   ball+stick   cartoon   rocket   rope   spacefill

Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q969E3-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2

PDB Structure Id	Ligand	Method	Resolution (Å)	Residues	Fraction of Total Protein	Pub Year	Title

PDB Structure Id	Fraction of Total Protein	Resolution	Pub Year

Pathways (5)

Reactome (4)

KEGG (1)

Class B/2 (Secretin family receptors) (R-HSA-373080)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Class B/2 (Secretin family receptors)	97 targets	R-HSA-373080
Reactome	GPCR ligand binding	460 targets	R-HSA-500792
Reactome	Signal Transduction	2704 targets	R-HSA-162582
Reactome	Signaling by GPCR	1212 targets	R-HSA-372790

Name	Explore in Pharos	Explore in Source
Class B/2 (Secretin family receptors)	97 targets	R-HSA-373080
GPCR ligand binding	460 targets	R-HSA-500792
Signal Transduction	2704 targets	R-HSA-162582
Signaling by GPCR	1212 targets	R-HSA-372790

Gene Ontology Terms (20)

Functions (4)

Components (5)

Processes (11)

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1 – 4 of 4

GO Term	Evidence	Assigned by
corticotropin-releasing hormone receptor binding	Inferred from Physical Interaction (IPI)	UniProtKB
G protein-coupled receptor binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
corticotropin-releasing hormone receptor 2 binding	Inferred from Electronic Annotation (IEA)	InterPro
hormone activity	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Protein-Protein Interactions (49)

Explore Interacting Targets

1 – 10 of 49

• See Interactions on String-DB

GOPC

Tbio

Novelty:  0.01110168

p_int:  0.99998438

p_ni:  0.00001562

Data Source:  BioPlex

RNF25

Tbio

Family:  Enzyme

Novelty:  0.08945219

p_int:  0.997288849

p_ni:  0.002710782

p_wrong:  3.69e-7

Data Source:  BioPlex

FAT4

Tbio

Novelty:  0.01739918

p_int:  0.99348456

p_ni:  0.00651544

Data Source:  BioPlex

ADGRV1

Tbio

Family:  GPCR

Novelty:  0.01398129

p_int:  0.993339778

p_ni:  0.006660222

Data Source:  BioPlex

HERC1

Tbio

Family:  Enzyme

Novelty:  0.04318441

p_int:  0.992164948

p_ni:  0.007835052

Data Source:  BioPlex

CD109

Tbio

Novelty:  0.01280272

p_int:  0.990337088

p_ni:  0.00966283

p_wrong:  8.1e-8

Data Source:  BioPlex

PCDH7

Tbio

Novelty:  0.04017185

p_int:  0.989039028

p_ni:  0.010960972

Data Source:  BioPlex

FREM2

Tbio

Novelty:  0.03382033

p_int:  0.971794508

p_ni:  0.028205492

Data Source:  BioPlex

PCDH20

Tbio

Novelty:  0.07862843

p_int:  0.928762998

p_ni:  0.071237002

Data Source:  BioPlex

FAT3

Tbio

Novelty:  0.03661008

p_int:  0.92277227

p_ni:  0.077227726

p_wrong:  4e-9

Data Source:  BioPlex

Publication Statistics

PubMed Score  111.09

PubMed score by year

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PubTator Score  309.36

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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UniProt Keyword Find Similar Targets

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3D-structure
Amidation
Complete proteome
Hormone
Polymorphism
Reference proteome
Secreted
Signal

GWAS Trait Find Similar Targets

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IGF-1 measurement
sleep duration
triglyceride measurement

MGI Phenotype Find Similar Targets

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behavior/neurological phenotype
endocrine/exocrine gland phenotype
homeostasis/metabolism phenotype
liver/biliary system phenotype