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Tbio
UCN3
Urocortin-3

Protein Summary
Description
Suppresses food intake, delays gastric emptying and decreases heat-induced edema. Might represent an endogenous ligand for maintaining homeostasis after stress. This gene encodes a member of the sauvagine/corticotropin-releasing factor/urotensin I family of proteins. The encoded preproprotein is proteolytically processed to generate the mature peptide hormone, which is secreted by pancreatic beta and alpha cells. This hormone is an endogenous ligand for corticotropin-releasing factor receptor 2 and may regulate insulin secretion in response to plasma glucose levels. Patients with type 2 diabetes exhibit reduced levels of the encoded protein in beta cells. In the brain, the encoded protein may be responsible for the effects of stress on appetite. [provided by RefSeq, May 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000380433
  • ENSP00000369798
  • ENSG00000178473

Symbol
  • SPC
  • SCP
  • SPC
  • UCNIII
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.74
biological process
0.65
cell type or tissue
0.57
cell line
0.49
tissue
0.49


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 111.09   (req: < 5)
Gene RIFs: 23   (req: <= 3)
Antibodies: 152   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 111.09   (req: >= 5)
Gene RIFs: 23   (req: > 3)
Antibodies: 152   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (49)
GOPC
Tbio
Novelty:  0.01110168
p_int:  0.99998438
p_ni:  0.00001562
Data Source:  BioPlex
RNF25
Tbio
Family:  Enzyme
Novelty:  0.08945219
p_int:  0.997288849
p_ni:  0.002710782
p_wrong:  3.69e-7
Data Source:  BioPlex
FAT4
Tbio
Novelty:  0.01739918
p_int:  0.99348456
p_ni:  0.00651544
Data Source:  BioPlex
ADGRV1
Tbio
Family:  GPCR
Novelty:  0.01398129
p_int:  0.993339778
p_ni:  0.006660222
Data Source:  BioPlex
HERC1
Tbio
Family:  Enzyme
Novelty:  0.04318441
p_int:  0.992164948
p_ni:  0.007835052
Data Source:  BioPlex
CD109
Tbio
Novelty:  0.01280272
p_int:  0.990337088
p_ni:  0.00966283
p_wrong:  8.1e-8
Data Source:  BioPlex
PCDH7
Tbio
Novelty:  0.04017185
p_int:  0.989039028
p_ni:  0.010960972
Data Source:  BioPlex
FREM2
Tbio
Novelty:  0.03382033
p_int:  0.971794508
p_ni:  0.028205492
Data Source:  BioPlex
PCDH20
Tbio
Novelty:  0.07862843
p_int:  0.928762998
p_ni:  0.071237002
Data Source:  BioPlex
FAT3
Tbio
Novelty:  0.03661008
p_int:  0.92277227
p_ni:  0.077227726
p_wrong:  4e-9
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Class B/2 (Secretin family receptors) (R-HSA-373080)

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Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class B/2 (Secretin family receptors)
Reactome
GPCR ligand binding
Reactome
Signal Transduction
Reactome
Signaling by GPCR
Name
Explore in Pharos
Explore in Source
Class B/2 (Secretin family receptors)
GPCR ligand binding
Signal Transduction
Signaling by GPCR
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (20)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
2
2
2
52.4
IGF-1 measurement
1
1
1
38.8
sleep duration
1
1
1
12.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
2
52.4
IGF-1 measurement
1
38.8
sleep duration
1
12.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
urocortin 3
VGNC:5872
450276
Macaque
urocortin 3
711921
Mouse
MGI:1932970
83428
Rat
RGD:1562213
498791
Dog
urocortin 3
VGNC:48110
100856134
Species
Name
OMA
EggNOG
Inparanoid
Chimp
urocortin 3
Macaque
urocortin 3
Mouse
Rat
Dog
urocortin 3
Publication Statistics
PubMed Score 111.09
PubMed score by year
PubTator Score 309.36
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title