Protein Summary
Suppresses food intake, delays gastric emptying and decreases heat-induced edema. Might represent an endogenous ligand for maintaining homeostasis after stress. This gene encodes a member of the sauvagine/corticotropin-releasing factor/urotensin I family of proteins. The encoded preproprotein is proteolytically processed to generate the mature peptide hormone, which is secreted by pancreatic beta and alpha cells. This hormone is an endogenous ligand for corticotropin-releasing factor receptor 2 and may regulate insulin secretion in response to plasma glucose levels. Patients with type 2 diabetes exhibit reduced levels of the encoded protein in beta cells. In the brain, the encoded protein may be responsible for the effects of stress on appetite. [provided by RefSeq, May 2016]
- ENST00000380433
- ENSP00000369798
- ENSG00000178473
- SPC
- SCP
- SPC
- UCNIII
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 0.74 | ||
biological process | 0.65 | ||
cell type or tissue | 0.57 | ||
cell line | 0.49 | ||
tissue | 0.49 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 111.09 (req: < 5)
Gene RIFs: 23 (req: <= 3)
Antibodies: 152 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 111.09 (req: >= 5)
Gene RIFs: 23 (req: > 3)
Antibodies: 152 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 15
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (49)
RNF25
Family: Enzyme
Novelty: 0.08945219
p_int: 0.997288849
p_ni: 0.002710782
p_wrong: 3.69e-7
Data Source: BioPlex
ADGRV1
Family: GPCR
Novelty: 0.01398129
p_int: 0.993339778
p_ni: 0.006660222
Data Source: BioPlex
HERC1
Family: Enzyme
Novelty: 0.04318441
p_int: 0.992164948
p_ni: 0.007835052
Data Source: BioPlex
CD109
Novelty: 0.01280272
p_int: 0.990337088
p_ni: 0.00966283
p_wrong: 8.1e-8
Data Source: BioPlex
Nearest Tclin Targets
Pathways (5)
Reactome (4)
KEGG (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Class B/2 (Secretin family receptors) | ||||
Reactome | GPCR ligand binding | ||||
Reactome | Signal Transduction | ||||
Reactome | Signaling by GPCR | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Class B/2 (Secretin family receptors) | ||||
GPCR ligand binding | ||||
Signal Transduction | ||||
Signaling by GPCR | ||||
Viral Interactions (0)
Gene Ontology Terms (20)
Functions (4)
Components (5)
Processes (11)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations ()
GWAS Traits (3)
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
triglyceride measurement | 2 | 2 | 2 | 52.4 | |||||
IGF-1 measurement | 1 | 1 | 1 | 38.8 | |||||
sleep duration | 1 | 1 | 1 | 12.1 | |||||
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
triglyceride measurement | 2 | 52.4 | |||||
IGF-1 measurement | 1 | 38.8 | |||||
sleep duration | 1 | 12.1 | |||||
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | urocortin 3 | VGNC:5872 | 450276 | |||||
Macaque | urocortin 3 | 711921 | ||||||
Mouse | MGI:1932970 | 83428 | ||||||
Rat | RGD:1562213 | 498791 | ||||||
Dog | urocortin 3 | VGNC:48110 | 100856134 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | urocortin 3 | |||||
Macaque | urocortin 3 | |||||
Mouse | ||||||
Rat | ||||||
Dog | urocortin 3 | |||||
Publication Statistics
PubMed Score 111.09
PubMed score by year
PubTator Score 309.36
PubTator score by year
Related Publications
Text Mined References (32)
GeneRif Annotations (23)
Items per page:
0 of 0
PMID | Year | Title |
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