You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
UCN3
Urocortin-3

Protein Summary
Description
Suppresses food intake, delays gastric emptying and decreases heat-induced edema. Might represent an endogenous ligand for maintaining homeostasis after stress. This gene encodes a member of the sauvagine/corticotropin-releasing factor/urotensin I family of proteins. The encoded preproprotein is proteolytically processed to generate the mature peptide hormone, which is secreted by pancreatic beta and alpha cells. This hormone is an endogenous ligand for corticotropin-releasing factor receptor 2 and may regulate insulin secretion in response to plasma glucose levels. Patients with type 2 diabetes exhibit reduced levels of the encoded protein in beta cells. In the brain, the encoded protein may be responsible for the effects of stress on appetite. [provided by RefSeq, May 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000380433
  • ENSP00000369798
  • ENSG00000178473

Symbol
  • SPC
  • SCP
  • SPC
  • UCNIII
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.74
biological process
0.65
cell type or tissue
0.57
cell line
0.49
tissue
0.49


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 111.09   (req: < 5)
Gene RIFs: 23   (req: <= 3)
Antibodies: 152   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 111.09   (req: >= 5)
Gene RIFs: 23   (req: > 3)
Antibodies: 152   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
2
2
2
52.4
IGF-1 measurement
1
1
1
38.8
sleep duration
1
1
1
12.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
2
52.4
IGF-1 measurement
1
38.8
sleep duration
1
12.1
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
urocortin 3
VGNC:5872
450276
Macaque
urocortin 3
711921
Mouse
MGI:1932970
83428
Rat
RGD:1562213
498791
Dog
urocortin 3
VGNC:48110
100856134
Species
Name
OMA
EggNOG
Inparanoid
Chimp
urocortin 3
Macaque
urocortin 3
Mouse
Rat
Dog
urocortin 3
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q969E3-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (5)
Class B/2 (Secretin family receptors) (R-HSA-373080)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class B/2 (Secretin family receptors)
Reactome
GPCR ligand binding
Reactome
Signal Transduction
Reactome
Signaling by GPCR
Name
Explore in Pharos
Explore in Source
Class B/2 (Secretin family receptors)
GPCR ligand binding
Signal Transduction
Signaling by GPCR
Gene Ontology Terms (20)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (49)
1 – 10 of 49
GOPC
Tbio
Novelty:  0.01110168
p_int:  0.99998438
p_ni:  0.00001562
Data Source:  BioPlex
RNF25
Tbio
Family:  Enzyme
Novelty:  0.08945219
p_int:  0.997288849
p_ni:  0.002710782
p_wrong:  3.69e-7
Data Source:  BioPlex
FAT4
Tbio
Novelty:  0.01739918
p_int:  0.99348456
p_ni:  0.00651544
Data Source:  BioPlex
ADGRV1
Tbio
Family:  GPCR
Novelty:  0.01398129
p_int:  0.993339778
p_ni:  0.006660222
Data Source:  BioPlex
HERC1
Tbio
Family:  Enzyme
Novelty:  0.04318441
p_int:  0.992164948
p_ni:  0.007835052
Data Source:  BioPlex
CD109
Tbio
Novelty:  0.01280272
p_int:  0.990337088
p_ni:  0.00966283
p_wrong:  8.1e-8
Data Source:  BioPlex
PCDH7
Tbio
Novelty:  0.04017185
p_int:  0.989039028
p_ni:  0.010960972
Data Source:  BioPlex
FREM2
Tbio
Novelty:  0.03382033
p_int:  0.971794508
p_ni:  0.028205492
Data Source:  BioPlex
PCDH20
Tbio
Novelty:  0.07862843
p_int:  0.928762998
p_ni:  0.071237002
Data Source:  BioPlex
FAT3
Tbio
Novelty:  0.03661008
p_int:  0.92277227
p_ni:  0.077227726
p_wrong:  4e-9
Data Source:  BioPlex
Publication Statistics
PubMed Score  111.09

PubMed score by year
PubTator Score  309.36

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: