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Tbio
TSLP
Thymic stromal lymphopoietin

Protein Summary
Description
Isoform 1: Cytokine that induces the release of T-cell-attracting chemokines from monocytes and, in particular, enhances the maturation of CD11c(+) dendritic cells. Can induce allergic inflammation by directly activating mast cells. Isoform 2: May act as an antimicrobial peptide in the oral cavity and on the skin. This gene encodes a hemopoietic cytokine proposed to signal through a heterodimeric receptor complex composed of the thymic stromal lymphopoietin receptor and the IL-7R alpha chain. It mainly impacts myeloid cells and induces the release of T cell-attracting chemokines from monocytes and enhances the maturation of CD11c(+) dendritic cells. The protein promotes T helper type 2 (TH2) cell responses that are associated with immunity in various inflammatory diseases, including asthma, allergic inflammation and chronic obstructive pulmonary disease. The protein is therefore considered a potential therapeutic target for the treatment of such diseases. Alternative splicing of this g ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000344895
  • ENSP00000339804
  • ENSG00000145777
  • ENST00000379706
  • ENSP00000427827
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.94
biological term
0.92
tissue sample
0.67
disease
0.64
phenotype
0.59


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 990.31   (req: < 5)
Gene RIFs: 221   (req: <= 3)
Antibodies: 627   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 990.31   (req: >= 5)
Gene RIFs: 221   (req: > 3)
Antibodies: 627   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (19)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
14
9
1
1.1
98.5
eosinophil count
3
4
6
97.6
eosinophil percentage of leukocytes
2
4
5
94
7
3
3
1.1
93.1
childhood onset asthma
2
2
0
1.2
88.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1.1
98.5
eosinophil count
6
97.6
eosinophil percentage of leukocytes
5
94
3
1.1
93.1
childhood onset asthma
0
1.2
88.7
Orthologs (3)
1 – 3 of 3
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
thymic stromal lymphopoietin
706194
Mouse
MGI:1855696
53603
Dog
thymic stromal lymphopoietin
VGNC:53251
607671
Species
Name
OMA
EggNOG
Inparanoid
Macaque
thymic stromal lymphopoietin
Mouse
Dog
thymic stromal lymphopoietin
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q969D9-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (9)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Interleukin-7 signaling
Reactome
Signaling by Interleukins
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
Interleukin-7 signaling
Signaling by Interleukins
Gene Ontology Terms (24)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Protein-Protein Interactions (177)
1 – 10 of 177
CRLF2
Tbio
Novelty:  0.00862501
Score:  0.999
Data Source:  Reactome,STRINGDB
IL7R
Tbio
Novelty:  0.00107223
Score:  0.995
Data Source:  Reactome,STRINGDB
STAT3
Tchem
Family:  TF
Novelty:  0.00011808
Score:  0.962
Data Source:  Reactome,STRINGDB
CCL17
Tbio
Novelty:  0.00160208
Score:  0.938
Data Source:  STRINGDB
IL33
Tbio
Novelty:  0.00072064
Score:  0.934
Data Source:  STRINGDB
IL13
Tbio
Novelty:  0.00021435
Score:  0.9
Data Source:  STRINGDB
IL4
Tbio
Novelty:  0.00005852
Score:  0.878
Data Source:  STRINGDB
TNFSF4
Tbio
Novelty:  0.00308925
Score:  0.857
Data Source:  STRINGDB
STAT5A
Tchem
Family:  TF
Novelty:  0.00074026
Score:  0.85
Data Source:  STRINGDB
FLG
Tbio
Novelty:  0.00072986
Score:  0.802
Data Source:  STRINGDB
Publication Statistics
PubMed Score  990.31

PubMed score by year
PubTator Score  364.38

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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