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Tbio
HLA-C
HLA class I histocompatibility antigen, Cw-17 alpha chain

Protein Summary
Description
Involved in the presentation of foreign antigens to the immune system. HLA-C belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Over one hundred HLA-C alleles h ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000400341
  • ENSP00000383195
  • ENSG00000206435
  • ENST00000400394
  • ENSP00000383244
  • ENSG00000206452

Symbol
  • D6S204
  • HLA-JY3
  • HLAC
  • MHC
  • HLAC
  • HLC-C
  • D6S204
  • PSORS1
  • HLA-JY3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
0.99
PubMedID
0.98
protein domain
0.97
transcription factor perturbation
0.94
interacting protein
0.87


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1553.1   (req: < 5)
Gene RIFs: 304   (req: <= 3)
Antibodies: 0   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1553.1   (req: >= 5)
Gene RIFs: 304   (req: > 3)
Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2100)
Items per page:
1 – 5 of 2100
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
4
9
50
99.7
lymphocyte count
4
9
50
99.7
lymphocyte count
4
9
30
99.7
lymphocyte count
4
9
50
99.7
lymphocyte count
4
9
50
99.7
Items per page:
1 – 5 of 2100
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
50
99.7
lymphocyte count
50
99.7
lymphocyte count
30
99.7
lymphocyte count
50
99.7
lymphocyte count
50
99.7
Orthologs (1)
1 – 1 of 1
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
major histocompatibility complex, class I, C
471962
Species
Name
OMA
EggNOG
Inparanoid
Chimp
major histocompatibility complex, class I, C
Pathways (40)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 15
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Reactome
Antigen processing-Cross presentation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Cytokine Signaling in Immune system
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Antigen processing-Cross presentation
Class I MHC mediated antigen processing & presentation
Cytokine Signaling in Immune system
Gene Ontology Terms (22)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Protein-Protein Interactions (290)
1 – 10 of 290
B2M
Tbio
Novelty:  0.00011248
Score:  0.999
Data Source:  STRINGDB
KIR2DL3
Tbio
Novelty:  0.00599644
Score:  0.995
Data Source:  STRINGDB
KIR2DL1
Tbio
Novelty:  0.00523657
Score:  0.994
Data Source:  STRINGDB
HLA-A
Tbio
Novelty:  0.00270731
Score:  0.984
Data Source:  STRINGDB
HLA-A
Tbio
Novelty:  0.00270731
Score:  0.984
Data Source:  STRINGDB
HLA-A
Tbio
Novelty:  0.00270731
Score:  0.984
Data Source:  STRINGDB
HLA-A
Tbio
Novelty:  0.00270731
Score:  0.984
Data Source:  STRINGDB
HLA-A
Tbio
Novelty:  0.00270731
Score:  0.984
Data Source:  STRINGDB
HLA-A
Tbio
Novelty:  0.00270731
Score:  0.984
Data Source:  STRINGDB
HLA-A
Tbio
Novelty:  0.00270731
Score:  0.984
Data Source:  STRINGDB
Publication Statistics
PubMed Score  1553.10

PubMed score by year
PubTator Score  2752.35

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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