Tbio MR1 Major histocompatibility complex class I-related gene protein

Protein Summary

Description

Antigen-presenting molecule specialized in presenting microbial vitamin B metabolites. Involved in the development and expansion of a small population of T-cells expressing an invariant T-cell receptor alpha chain called mucosal-associated invariant T-cells (MAIT). MAIT lymphocytes are preferentially located in the gut lamina propria and therefore may be involved in monitoring commensal flora or serve as a distress signal. Expression and MAIT cell recognition seem to be ligand-dependent. MAIT (mucosal-associated invariant T-cells) lymphocytes represent a small population of T-cells primarily found in the gut. The protein encoded by this gene is an antigen-presenting molecule that presents metabolites of microbial vitamin B to MAITs. This presentation may activate the MAITs to regulate the amounts of specific types of bacteria in the gut. Several transcript variants encoding different isoforms have been found for this gene, and a pseudogene of it has been detected about 36 kbp upstream on the same chromosome. [provided by RefSeq, Jul 2015]

Uniprot Accession IDs

• Q95460
• A8K2V9
• B4E3B1
• O97985
• O97986
• Q53GM1
• Q95HB8
• Q9MY23
• Q9NPL2
• Q9TQB3
• Q9TQB9
• Q9TQK3
• MHC class I-related gene protein

Gene Name

• MR1

Ensembl ID

• ENST00000282990
• ENSP00000282990
• ENSG00000153029
• ENST00000367579
• ENSP00000356551
• ENST00000367580
• ENSP00000356552
• ENST00000434571
• ENSP00000388504
• ENST00000614012
• ENSP00000477563
• ENST00000617803
• ENSP00000478976

Symbol

• HLALS

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.97
virus perturbation	0.96
kinase perturbation	0.91
gene perturbation	0.71
co-expressed gene	0.61

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.6   (req: < 5)

Gene RIFs: 48   (req: <= 3)

Antibodies: 156   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.6   (req: >= 5)

Gene RIFs: 48   (req: > 3)

Antibodies: 156   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0