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Tbio
MR1
Major histocompatibility complex class I-related gene protein

Protein Summary
Description
Antigen-presenting molecule specialized in presenting microbial vitamin B metabolites. Involved in the development and expansion of a small population of T-cells expressing an invariant T-cell receptor alpha chain called mucosal-associated invariant T-cells (MAIT). MAIT lymphocytes are preferentially located in the gut lamina propria and therefore may be involved in monitoring commensal flora or serve as a distress signal. Expression and MAIT cell recognition seem to be ligand-dependent. MAIT (mucosal-associated invariant T-cells) lymphocytes represent a small population of T-cells primarily found in the gut. The protein encoded by this gene is an antigen-presenting molecule that presents metabolites of microbial vitamin B to MAITs. This presentation may activate the MAITs to regulate the amounts of specific types of bacteria in the gut. Several transcript variants encoding different isoforms have been found for this gene, and a pseudogene of it has been detected about 36 kbp upstream ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000282990
  • ENSP00000282990
  • ENSG00000153029
  • ENST00000367579
  • ENSP00000356551
  • ENST00000367580
  • ENSP00000356552
  • ENST00000434571
  • ENSP00000388504
  • ENST00000614012
  • ENSP00000477563
  • ENST00000617803
  • ENSP00000478976

Symbol
  • HLALS
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
virus perturbation
0.96
kinase perturbation
0.91
gene perturbation
0.71
co-expressed gene
0.61


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.57   (req: < 5)
Gene RIFs: 25   (req: <= 3)
Antibodies: 156   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.57   (req: >= 5)
Gene RIFs: 25   (req: > 3)
Antibodies: 156   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (117)
TMPRSS11B
Tdark
Family:  Enzyme
Novelty:  1.20690443
p_int:  0.970116446
p_ni:  0.029883534
p_wrong:  2e-8
Data Source:  BioPlex
IL17RC
Tclin
Novelty:  0.01844832
p_int:  0.946770768
p_ni:  0.05321652
p_wrong:  0.000012711
Data Source:  BioPlex
HLA-E
Tbio
Novelty:  0.00216583
p_int:  0.916221049
p_ni:  0.083778951
Score:  0.667
Data Source:  BioPlex,STRINGDB
IFNLR1
Tbio
Novelty:  0.01990628
p_int:  0.863482016
p_ni:  0.129479787
p_wrong:  0.007038197
Data Source:  BioPlex
DHFR2
Tbio
Family:  Enzyme
Novelty:  0.02374466
p_int:  0.863419241
p_ni:  0.136580419
p_wrong:  3.4e-7
Data Source:  BioPlex
HFE
Tbio
Novelty:  0.00042077
p_int:  0.848478296
p_ni:  0.15152167
p_wrong:  3.4e-8
Data Source:  BioPlex
ZACN
Tchem
Family:  IC
Novelty:  0.21891621
p_int:  0.829610942
p_ni:  0.170389058
Data Source:  BioPlex
MPPE1
Tbio
Family:  Enzyme
Novelty:  0.16027847
p_int:  0.828447576
p_ni:  0.171552424
Data Source:  BioPlex
ST8SIA4
Tbio
Family:  Enzyme
Novelty:  0.00338436
p_int:  0.79127891
p_ni:  0.20872109
Data Source:  BioPlex
TMEM30A
Tbio
Novelty:  0.05115559
p_int:  0.777034055
p_ni:  0.222964556
p_wrong:  0.000001389
Score:  0.524
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
1
1
1
72.9
eosinophil count
2
2
2
62.8
glomerular filtration rate
3
1
2
7.2
62.5
myeloid white cell count
1
1
1
61.4
leukocyte count
1
1
1
53.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
1
72.9
eosinophil count
2
62.8
glomerular filtration rate
2
7.2
62.5
myeloid white cell count
1
61.4
leukocyte count
1
53.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
major histocompatibility complex, class I-related
457562
Macaque
major histocompatibility complex class I-related gene protein
718365
Mouse
MGI:1195463
15064
Rat
RGD:1593291
25119
Horse
major histocompatibility complex, class I-related
VGNC:20304
100054060
Species
Name
OMA
EggNOG
Inparanoid
Chimp
major histocompatibility complex, class I-related
Macaque
major histocompatibility complex class I-related gene protein
Mouse
Rat
Horse
major histocompatibility complex, class I-related
Publication Statistics
PubMed Score 7.57
PubMed score by year
PubTator Score 169.46
PubTator score by year
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Related Publications
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PMID
Year
Title